Introduction and evaluation of peer assisted learning in first-year undergraduate bioscience.

Bioscience undergraduates, enrolled on a first-year microbiology module, participated in the introduction of peer-assisted learning (PAL) into the curriculum. The class of 122 students was divided into groups of six to ten, with one volunteer from each group assuming the role of group leader (peer tutor). Group leaders attended a compulsory training session at which they were guided through the tutorial they would lead with their peer group. The primary aim of PAL was to raise students’ self-confidence in their problem-solving and numerical skills. Students were provided with the opportunity to practise problem-solving questions from past examination papers and to discuss with their peers their answers and any difficulties they encountered, particularly with regard to any mathematics involved. Students’ perceptions of their PAL experience, their group leader’s contribution and the training provided for group leaders were evaluated using a questionnaire. The latter revealed that bioscience undergraduates found PAL a highly valuable learning experience. In particular, they found the less formal, comfortable and relaxed atmosphere of the PAL session provided them with greater freedom to ask questions and exerted less pressure on them to answer questions correctly than a more formal staff-led session, as well as assisting them to understand the topics covered

Operando visualisation and multi-scale tomography studies of dendrite formation and dissolution in zinc batteries

Alternative battery technologies are required to meet growing energy demands and address the limitations of present technologies. As such, it is necessary to look beyond lithium-ion batteries. Zinc batteries enable high power density while being sourced from ubiquitous and cost-effective materials. This paper presents, for the first time known to the authors, multi-length scale tomography studies of failure mechanisms in zinc batteries with and without commercial microporous separators. In both cases, dendrites were grown, dissolved, and regrown, critically resulting in different morphology of dendritic layer formed on both the electrode and the separator. The growth of dendrites and their volume-specific areas were quantified using tomography and radiography data in unprecedented resolution. High-resolution ex situ analysis was employed to characterize single dendrites and dendritic deposits inside the separator. The findings provide unique insights into mechanisms of metal-battery failure effected by growing dendrites

Guidelines for the rational design and engineering of 3D manufactured solid oxide fuel cell composite electrodes

The growth of 3D printing has opened the scope for designing microstructures for solid oxide fuel cell s (SOFCs) with improved power density and lifeti me. This technique can introduce structural modifications at a scale larger than particle size but smaller than cell size, such as by inserting electrolyte pillars of ~5 - 100 µ m. This study sets the minimum requirements for the rational design of 3D printed electrodes based on an electrochemical model and analytical solutions for functional layers with negligible electronic resistance and no mixed conduction . Results show that this structural modification enhances the power density when the ratio k eff betwee n effective conductivity and bulk conductivity of the ionic phase is smaller than 0.5. The maximum performance improvement is predicted as a function of k eff . A design study on a wide range of pillar shapes indicates that improvements are achieved by any s tructural modification which provides ionic conduction up to a characteristic thickness ~10 - 40 µ m without removing active volume at the electrolyte interface. The best performance is reached for thin ( ~80 µ m) pillars when the composite electrode is optimised for ma ximum three - phase boundary density, pointing towards the design of scaffolds with well - defined geometry and fractal structures

Electrochemical simulation of Solid Oxide Fuel Cell electrodes: an integrated approach to address the microstructure-performance correlation

Understanding the complex interplay between electrode microstructure and electrochemical performance is one of the key aspects for the optimization of Solid Oxide Fuel Cells (SOFC). Physically-based modelling, at different levels of sophistication, can provide a valuable insight in order to help the interpretation of experimental data and provide design indications to improve electrode stability and performance. In this contribution we summarize the different modelling approaches used in our group, ranging from physically-based equivalent circuits, continuum conservation models and 3D models solved within the reconstructed electrode microstructure. When necessary, these models are coupled with percolation theory, packing algorithms and tomographic techniques. Special focus is given to the application of the models to interpret impedance spectra and their thorough validation under different conditions. Examples include the application of the models to electrodes with different microstructures, the study of the degradation mechanisms of Ni-infiltrated anodes as well as impedance simulations in real microstructures (Figure 1). Results reveal that coupling physically-based modelling, impedance spectroscopy and 3D tomography is a promising approach to gain a fundamental understanding of the phenomena occurring at different length scales in SOFC electrodes, allowing for interpreting and planning experiments as well as to design more stable and more efficient electrodes

Rare novel CYP2U1 and ZFYVE26 variants identified in two Pakistani families with spastic paraplegia

BAKGROUND: Hereditary Spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of degenerative disorders characterized by progressive spasticity and weakness of the lower limbs. This study aimed to identify causative gene variants in two unrelated consanguineous Pakistani families presented with 2 different forms of HSP. METHODS: Whole exome sequencing (WES) was performed in the two families and variants were validated by Sanger sequencing and segregation analysis. ANALYSIS: In family A, a homozygous pathogenic variant in ZFYVE26 was identified in one family. While in family B, a frameshift variant in CYP2U1 was identified in 4 affected individuals presented with clinical features of SPG56. Our study is the first report of ZFYVE26 mutations causing HSP in the Pakistani population and the second report of CYP2U1 in a Pakistani family. CONCLUSIONS: Our findings enhance the clinical and genetic variability associated with two rare autosomal recessive HSP genes, highlighting the complexity of HSPs. These findings further emphasize the usefulness of WES as a powerful diagnostic tool

Transition Radiation Spectroscopy with Prototypes of the ALICE TRD

We present measurements of the transition radiation (TR) spectrum produced in an irregular radiator at different electron momenta. The data are compared to simulations of TR from a regular radiator.Comment: 4 pages, 5 Figures, Proceedings for "TRDs for the 3rd millennium" (Sept. 4-7, 2003, Bari, Italy

Explicit Kundt type II and N solutions as gravitational waves in various type D and O universes

A particular yet large class of non-diverging solutions which admits a cosmological constant, electromagnetic field, pure radiation and/or general non-null matter component is explicitly presented. These spacetimes represent exact gravitational waves of arbitrary profiles which propagate in background universes such as Minkowski, conformally flat (anti-)de Sitter, Edgar-Ludwig, Bertotti-Robinson, and type D (anti-)Nariai or Plebanski-Hacyan spaces, and their generalizations. All possibilities are discussed and are interpreted using a unifying simple metric form. Sandwich and impulsive waves propagating in the above background spaces with different geometries and matter content can easily be constructed. New solutions are identified, e.g. type D pure radiation or explicit type II electrovacuum waves in (anti-)Nariai universe. It is also shown that, in general, there are no conformally flat Einstein-Maxwell fields with a non-vanishing cosmological constant.Comment: 17 pages, LaTeX 2e. v2: added two references concerning generalized Kerr-Schild transformations, minor changes in the tex