Developments on a Cold Bead Pull Test Stand for SRF Cavities

Final tuning and field profile characterization of SRF cavities always takes place at room temperature. However, important questions remains as to what happens when the cavity is cooled to LHe temperature, in particular with multi cell systems. To enable the characterization of cavities in the cold, we have designed and commissioned a cold bead pull test stand at HZB. The present test stand is designed to be integrated in HoBiCaT Horizontal bi cavity testing facility [1] with the ability to provide electric field profile measurements under realistic superconducting conditions T 1.8K . In this paper mechanical and operational details of the apparatus will be described as well as future plans for the development and usage of this facilit

Cold Bead Pull Test Stand for SRF Cavities

Bead pull measurements represent a final step in the fabrication process of an SRF cavity. These tests allow to characterise the flatness of the field profile in order to mechanically tune the cavity to achieve design specifications. The realization of a bead pull measurement is always performed at room temperature and therefore it is influenced by the material physical properties resulting into higher surface losses as compared to the superconducting state. Moreover, questions like mechanical deformation due to asymmetrical thermal shrinkage through the cool down process and the stress created by the tuner actuation have not yet been answered experimentally. In this paper, an upgrade of the former Cold Bead pull system developed by HZB [1] is presented. This test stand is capable of holding a 9 cell Tesla cavity at LHe temperature providing a realistic insight to cavity parameters under operation conditions. In addition, a copper test pill box is placed in series with the multi cell cavity in order to perform 1.8K calibration of the bead. Test results of the commissioned test stand prototype are presented on this pape

Ecuaciones diferenciales del c?lculo de variaciones

46 p. Recurso Electr?nic

High Q Cavity Operation Study on the Thermoelectrically Induced Contribution to RF Surface Resistance

We present a study concerning the operation of a superconducting RF cavity non doped niobium in horizontal testing with the focus on understanding the thermoelectrically induced contribution to the surface resistance. Starting in 2009, we suggested a means of reducing the residual resistance by warming up a cavity after initial cooldown to about 20 K and cooling it down again [1]. In subsequent studies we used this technique to manipulate the residual resistance by more than a factor of 2 [2]. We postulated that thermocurrents during cooldown generate additional trapped magnetic flux that impacts the cavity quality factor. Since several questions remained open, we present here a more extensive study including measurement of two additional passband modes of the 9 cell cavity that confirms the effect. We also discuss simulations that substantiate the claim. While the layout of the cavity LHe tank system is cylindrically symmetric, we show that the temperature dependence of the material parameters result in a non symmetric current distribution. Hence a significant amount of magnetic flux can be generated at the RF surface resulting in an increased surface resistance [3

Quasi-Exact Solvability and the direct approach to invariant subspaces

We propose a more direct approach to constructing differential operators that preserve polynomial subspaces than the one based on considering elements of the enveloping algebra of sl(2). This approach is used here to construct new exactly solvable and quasi-exactly solvable quantum Hamiltonians on the line which are not Lie-algebraic. It is also applied to generate potentials with multiple algebraic sectors. We discuss two illustrative examples of these two applications: an interesting generalization of the Lam\'e potential which posses four algebraic sectors, and a quasi-exactly solvable deformation of the Morse potential which is not Lie-algebraic.Comment: 17 pages, 3 figure

RF Feedback and Detuning Studies for the BESSY Variable Pulse Length Storage Ring Higher Harmonic SC Cavities

For the feasibility of the BESSY VSR upgrade project of BESSY II two higher harmonic systems at a factor of 3 and 3.5 of the ring s RF fundamental of 500 MHz will be installed in the ring. Operating in continuous wave at high average accelerating field of 20 MV m and phased at zerocrossing, the superconducting cavities have to be detuned within tight margins to ensure stable operation and lowpower consumption at a loaded Q of 5 107. The field variation of the cavities is mainly driven by the repetitive transient beam loading of the envisaged complex bunch fill pattern in the ring. Within this work combined LLRF cavity and longitudinal beam dynamics simulation will demonstrate the limits for stable operation, especially the coupling between synchrotron oscillation and RF feedback settings. Further impact by beam current decay and top up injection shots are being simulate

Production of the 1.5 GHz fundamental power couplers for VSR demo

Research Instruments RI and Thales have been pro ducing the first two prototype 1.5 GHz fundamental power couplers for the VSR Variable pulse length Storage Ring DEMO since early 2021 and delivered these prototypes in late March 2023. These couplers are designed to provide up to 16 kW CW power to two 1.5 GHz superconducting cavities of the VSR DEMO module and provide variable coupling with a Qext range from 6 106 to 6 107. The paper describes the challenges in fabricating a scaled coupler and provides details on the modifications to the design as a re sult of these challenges. The impact of the late stage design modification is discussed along with how this affects future conditioning plan

Identification of a Profile of Neutrophil-Derived Granule Proteins in the Surface of Gold Nanoparticles after Their Interaction with Human Breast Cancer Sera

It is well known that the interaction of a nanomaterial with a biological fluid leads to the formation of a protein corona (PC) surrounding the nanomaterial. Using standard blood analyses, alterations in protein patterns are difficult to detect. PC acts as a "nano-concentrator" of serum proteins with affinity for nanoparticles' surface. Consequently, characterization of PC could allow detection of otherwise undetectable changes in protein concentration at an early stage of a disease, such as breast cancer (BC). Here, we employed gold nanoparticles (AuNPsdiameter: 10.02 +/- 0.91 nm) as an enrichment platform to analyze the human serum proteome of BC patients (n = 42) and healthy controls (n = 42). Importantly, the analysis of the PC formed around AuNPs after their interaction with serum samples of BC patients showed a profile of proteins that could differentiate breast cancer patients from healthy controls. These proteins developed a significant role in the immune and/or innate immune system, some of them being neutrophil-derived granule proteins. The analysis of the PC also revealed serum proteome alterations at the subtype level

A Novel Nanoproteomic Approach for the Identification of Molecular Targets Associated with Thyroid Tumors

A thyroid nodule is the most common presentation of thyroid cancer; thus, it is extremely important to differentiate benign from malignant nodules. Within malignant lesions, classification of a thyroid tumor is the primary step in the assessment of the prognosis and selection of treatment. Currently, fine-needle aspiration biopsy (FNAB) is the preoperative test most commonly used for the initial thyroid nodule diagnosis. However, due to some limitations of FNAB, different high-throughput "omics" approaches have emerged that could further support diagnosis based on histopathological patterns. In the present work, formalin-fixed paraffin-embedded (FFPE) tissue specimens from normal (non-neoplastic) thyroid (normal controls (NCs)), benign tumors (follicular thyroid adenomas (FTAs)), and some common types of well-differentiated thyroid carcinoma (follicular thyroid carcinomas (FTCs), conventional or classical papillary thyroid carcinomas (CV-PTCs), and the follicular variant of papillary thyroid carcinomas (FV-PTCs)) were analyzed. For the first time, FFPE thyroid samples were deparaffinized using an easy, fast, and non-toxic method. Protein extracts from thyroid tissue samples were analyzed using a nanoparticle-assisted proteomics approach combined with shotgun LC-MS/MS. The differentially regulated proteins found to be specific for the FTA, FTC, CV-PTC, and FV-PTC subtypes were analyzed with the bioinformatic tools STRING and PANTHER showing a profile of proteins implicated in the thyroid cancer metabolic reprogramming, cancer progression, and metastasis. These proteins represent a new source of potential molecular targets related to thyroid tumors

Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial

HIV and antiretroviral therapy affect lipid metabolism. Lipidomics quantifies several individual species that are overlooked using conventional biochemical analyses, outperforming traditional risk equations. We aimed to compare the plasma lipidomic profile of HIV patients taking efavirenz (EFV) or rilpivirine (RPV). Patients >/= 18 years old on EFV co-formulated with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) with HIV-RNA /=6 months were randomized to continue EFV/FTC/TDF (n = 14) or switch to RPV/FTC/TDF (n =15). Lipidomic analyses conducted by mass spectrometry (MS) were performed at baseline and after 12 and 24 weeks. OWLiver((R)) Care and OWLiver((R)) tests were performed to estimate the presence of fatty liver disease (NAFLD). No significant differences (83% male, median age 44 years, 6 years receiving EFV/FTC/TDF, CD4(+) count 740 cells/mm(3), TC 207 [57 HDL-C/133 LDL-C] mg/dL, TG 117 mg/dL) were observed between the groups at baseline. Significant reductions in plasma lipids and lipoproteins but increased circulating bilirubin concentrations were observed in patients who switched to RPV/FTC/TDF. Patients on RPV/FTC/TDF showed a decrease in the global amount of storage lipids (-0.137 log2 [fold-change] EFV vs. 0.059 log2 [fold-change] RPV) but an increase in lysophosphatidylcholines (LPCs) and total steroids. Compared with EFV, RPV increased metabolites with anti-inflammatory properties and reduced the repository of specific lipotoxic lipids