On the Symmetric Space Sigma-Model Kinematics

The solvable Lie algebra parametrization of the symmetric spaces is discussed. Based on the solvable Lie algebra gauge two equivalent formulations of the symmetric space sigma model are studied. Their correspondence is established by inspecting the normalization conditions and deriving the field transformation laws.Comment: 17 page

Symmetric space sigma-model dynamics: Current formalism

After explicitly constructing the symmetric space sigma model lagrangian in terms of the coset scalars of the solvable Lie algebra gauge in the current formalism we derive the field equations of the theory.Comment: 10 page

Dynamic PRA: an Overview of New Algorithms to Generate, Analyze and Visualize Data

State of the art PRA methods, i.e. Dynamic PRA (DPRA) methodologies, largely employ system simulator codes to accurately model system dynamics. Typically, these system simulator codes (e.g., RELAP5 ) are coupled with other codes (e.g., ADAPT, RAVEN that monitor and control the simulation. The latter codes, in particular, introduce both deterministic (e.g., system control logic, operating procedures) and stochastic (e.g., component failures, variable uncertainties) elements into the simulation. A typical DPRA analysis is performed by: 1. Sampling values of a set of parameters from the uncertainty space of interest 2. Simulating the system behavior for that specific set of parameter values 3. Analyzing the set of simulation runs 4. Visualizing the correlations between parameter values and simulation outcome Step 1 is typically performed by randomly sampling from a given distribution (i.e., Monte-Carlo) or selecting such parameter values as inputs from the user (i.e., Dynamic Event Tre

The effect of initial pH and retention time on boron removal by continuous electrocoagulation process

In this study, factors influencing boron removal via the continuous electrocoagulation process were investigated at lab-scale. Different influent pH values (4, 5, 6, 7.45 and 9) and contact times (10, 25, 50 and 100 min) were examined as variable parameters. Plate-type aluminium electrodes with 5 mm distance between them were used. All the experiments were conducted in continuous mode and the current density was kept constant at 5 A throughout the whole experimental period. The initial boron concentration was selected to be 1000 mg L-1. The first set of experiments concerning the influence of the influent pH showed that the highest boron removal (67%) was obtained at pH=6 since it was the optimal pH for boron precipitation through aluminium borate formation. Under the constant current density of the study and with the initial pH adjusted to 6, increasing the duration of the electrocoagulation process from 10 to 100 min resulted in raising the boron removal from 45 to 79% during the second set of experiments. The greater duration of the electrocagulation process enabled higher aluminium dissolution, thus allowing the existence of a higher number of coagulants within the reactor. Moreover, it enhanced boron precipitation because of the longer contact time between the boron ions and the coagulants. After optimizing significant parameters such as the influent pH and the electrocagulation duration, the continuous electrocoagulation process was found to constitute an effective alternative for boron removal

Effect of Coulomb interactions on the physical observables of graphene

We give an update of the situation concerning the effect of electron-electron interactions on the physics of a neutral graphene system at low energies. We revise old renormalization group results and the use of 1/N expansion to address questions of the possible opening of a low-energy gap, and the magnitude of the graphene fine structure constant. We emphasize the role of Fermi velocity as the only free parameter determining the transport and electronic properties of the graphene system and revise its renormalization by Coulomb interactions in the light of recent experimental evidence.Comment: Proceedings of the Nobel Symposium on graphene 2010, to appear as a special issue in Physica Script

Common denominators in the immunobiology of IgG4 autoimmune diseases: What do glomerulonephritis, pemphigus vulgaris, myasthenia gravis, thrombotic thrombocytopenic purpura and autoimmune encephalitis have in common?

IgG4 autoimmune diseases (IgG4-AID) are an emerging group of autoimmune diseases that are caused by pathogenic autoantibodies of the IgG4 subclass. It has only recently been appreciated, that members of this group share relevant immunobiological and therapeutic aspects even though different antigens, tissues and organs are affected: glomerulonephritis (kidney), pemphigus vulgaris (skin), thrombotic thrombocytopenic purpura (hematologic system) muscle-specific kinase (MuSK) in myasthenia gravis (peripheral nervous system) and autoimmune encephalitis (central nervous system) to give some examples. In all these diseases, patients’ IgG4 subclass autoantibodies block protein-protein interactions instead of causing complement mediated tissue injury, patients respond favorably to rituximab and share a genetic predisposition: at least five HLA class II genes have been reported in individual studies to be associated with several different IgG4-AID. This suggests a role for the HLA class II region and specifically the DRβ1 chain for aberrant priming of autoreactive T-cells toward a chronic immune response skewed toward the production of IgG4 subclass autoantibodies. The aim of this review is to provide an update on findings arguing for a common pathogenic mechanism in IgG4-AID in general and to provide hypotheses about the role of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID

Wormholes supported by chiral fields

We consider static, spherically symmetric solutions of general relativity with a nonlinear sigma model (NSM) as a source, i.e., a set of scalar fields $\Phi = (\Phi^1,...,\Phi^n)$ (so-called chiral fields) parametrizing a target space with a metric $h_{ab}(\Phi)$. For NSM with zero potential $V(\Phi)$, it is shown that the space-time geometry is the same as with a single scalar field but depends on $h_{ab}$. If the matrix $h_{ab}$ is positive-definite, we obtain the Fisher metric, originally found for a canonical scalar field with positive kinetic energy; otherwise we obtain metrics corresponding to a phantom scalar field, including singular and nonsingular horizons (of infinite area) and wormholes. In particular, the Schwarzschild metric can correspond to a nontrivial chiral field configuration, which in this case has zero stress-energy. Some explicit examples of chiral field configurations are considered. Some qualitative properties of NSM configurations with nonzero potentials are pointed out.Comment: 5 two-column pages, to appear in Grav. Cosmo

Thalassemia mutations in Gaziantep, Turkey

Ninety-eight postnatal and six prenatal cases of thalassemia were studied by the reverse dot-blot hybridization technique in the city of Gaziantep, Turkey. We found the following mutations: IVS 1.110 (G>A) in 29.1%, IVS 2.1 (G>A) in 12.3%, IVS 1.1 (G>A) in 7.7%, Codon 8 (-AA) in 5.6%, -30 (T>A) in 4.6%, IVS 1.6 (T>C) in 4.6%, Codon 39 (C>T) in 3.6%, Codon 44 (-C) in 3.1%, IVS 2.745 (C>G) in 1.5%, Codon 8/9 (+G) in 2.1%, Codon 36/37 (-T) in 2.1%, IVS 1.5 (G>C) in 2.1%, Codon 22 (7pb del) in 0.5%, Codon 5 (-CT) in 0.5% while 20.9% were undetermined. 54 of the thalassemia patients were homozygotes, 12 were compound heterozygous and 31 were heterozygotes. In one allele of 5 thalassemia patients, - thalassemia mutation (3.7 single gene deletions in 1 patient, anti-3.7 gene triplication in 4 patients) wasdetermined at the same time. Finally, this is the first comprehensive study in this region and percentage of and - globin genes mutation is 2.6 and 79.4%, respectively

Overview of experimental results in PbPb collisions at sqrt{s_NN} = 2.76 TeV by the CMS Collaboration

The CMS experiment at the LHC is a general-purpose apparatus with a set of large acceptance and high granularity detectors for hadrons, electrons, photons and muons, providing unique capabilities for both proton-proton and ion-ion collisions. The data collected during the November 2010 PbPb run at sqrt{s_NN} = 2.76 TeV was analyzed and multiple measurements of the properties of the hot and dense matter were obtained. Global event properties, detailed study of jet production and jet properties, isolated photons, quarkonia and weak bosons were measured and compared to pp data and Monte Carlo simulations.Comment: 8 pages, 10 figures, proceedings for Quark Matter 2011, Annecy, France, May 23-28, 201

Oscillating axion bubbles as alternative to supermassive black holes at galactic centers

Recent observations of near-infrared and X-ray flares from Sagittarius A*, which is believed to be a supermassive black hole at the Galactic center, show that the source exhibits about 20-minute periodic variability. Here we provide arguments based on a quantitative analysis that supermassive objects at galactic centers may be bubbles of dark matter axions rather than black holes. An oscillating axion bubble can explain periodic variability of Sagittarius A* and yields the axion mass about 0.6 meV which fits in the open axion mass window. The bubble scenario with no other free parameters explains lack of supermassive "black holes" with mass M<10^6 M_{Sun}. Low-mass bubbles decay fast and as a result are very rare. We also found that the mass of an axion bubble can not exceed 1.5\times 10^9 M_{Sun}, in agreement with the upper limit on the supermassive "black hole" mass obtained from observations. Our finding, if confirmed, suggests that Einstein general relativity is invalid for strong gravity and the gravitational field for the bubble effectively becomes repulsive at large potential. Imaging a shadow of the "black hole" at the Galactic center with VLBI in the next decade can distinguish between the black hole and the oscillating axion bubble scenarios. In the case of axion bubble, a steady shadow will not be observed. Instead, the shadow will appear and disappear periodically with a period of about 20 min.Comment: 10 pages, 4 figures, added derivation of the exponential metric based on superposition principl