Co-Evolution vs. Co-existence: The Effect of Accretion Modelling on the Evolution of Black Holes and Host Galaxies

We append two additional black hole (BH) accretion models, namely viscous disc and gravitational torque-driven accretion, into the Numerical Investigation of a Hundred Astrophysical Objects (NIHAO) project of galaxy simulations. We show that these accretion models, characterized by a weaker dependence on the BH mass compared to the commonly used Bondi-Hoyle accretion, naturally create a common evolutionary track (co-existence) between the mass of the BH and the stellar mass of the galaxy, even without any direct coupling via feedback (FB). While FB is indeed required to control the final BH and stellar mass of the galaxies, our results suggest that FB might not be the leading driver of the cosmic co-evolution between these two quantities; in these models, co-evolution is simply determined by the shared central gas supply. Conversely, simulations using Bondi-Hoyle accretion show a two-step evolution, with an early growth of stellar mass followed by exponential growth of the central supermassive black hole (SMBH). Our results show that the modelling of BH accretion (sometimes overlooked) is an extremely important part of BH evolution and can improve our understanding of how scaling relations emerge and evolve, and whether SMBH and stellar mass co-exist or co-evolve through cosmic time.Comment: 13 pages, 10 figure

EVALUATION OF THE APPLICABILITY OF A TURBULENT WAKE INLET BOUNDARY CONDITION

With the objective of reducing the computational cost of the iterative processes of aerodynamic components design, tests were carried out to study under what conditions, and with what difference, only part of the calculation domain can be solved using as input information obtained from complete simulations already solved. An experimental study of an airfoil exposed to the wake interference of an upstream airfoil at a Reynolds number of 150,000 was used to verify the solutions of the Reynolds-Averaged Navier-Stokes equations solved applying the k-ω Shear Stress Transport model for turbulence closure. A Grid Convergence Index study was performed to verify if the solution of the equations for the adopted discretization leads to results within the asymptotic range. With the physical coherence of the numerical methodology verified, comparisons between the simulations with the domain comprising the two airfoils and the domain comprising only the downstream airfoil were performed. Computational time reductions in the order of 40% are observed. The differences in the aerodynamic coefficients for the two types of simulation are presented as a function of distances non-dimensionalized by the characteristic length of the body that disturbs the flow forming the wake, showing that the difference between the two methods was inversely proportional to the distance between the two bodies. Behavior that was maintained until a point where the simulation diverges, equivalent to 25% of the characteristic length of the body that generates the wake

Bilateral papillitis and unilateral focal chorioretinitis as the presenting features of syphilis.

BACKGROUND: Syphilis is a multisystem bacterial infection caused by Treponema pallidum. The incidence of infection in the United States has risen by more than 75% since the year 2000, when it was at a low of 2.1 per 100,000 people. Ocular involvement may occur in any stage of infection and may present in a variety of ways, with posterior uveitis being the most common manifestation. We report a case of ocular syphilis infection with an unusual presentation of bilateral non-granulomatous panuveitis with papillitis and unilateral focal chorioretinitis. FINDINGS: This is a retrospective case report with literature review. A 39-year-old Caucasian female presented with a 2-week history of bilateral ocular flashes and left eye pain. Dilated fundus examination revealed mild optic disc edema in both eyes, the right eye more than the left. In the left eye, there was an area of retinal elevation and whitening involving the peripheral retina. Fluorescein angiography, B-scan ultrasonography, and ocular coherence tomography were performed, and laboratory tests were ordered based on the clinical presentation. After rapid plasma reagin (RPR) and fluorescent treponemal antibody absorption (FTA-Abs) were positive, syphilitic uveitis was confirmed, and the patient was admitted for a 14-day course of high-dose intravenous penicillin G. CONCLUSIONS: The first signs and symptoms of syphilis may be ocular, which can lead to a diagnostic challenge. A high index of suspicion is the key for early diagnosis of ocular syphilis. Prompt treatment with intravenous penicillin G is highly effective in resolving the infection

Diabetic retinopathy: variations in patient therapeutic outcomes and pharmacogenomics.

Diabetes and its microvascular complications in patients poses a significant challenge and constitutes a major health problem. When it comes to manifestations in the eye, each case of diabetic retinopathy (DR) is unique, in terms of the phenotype, genotype, and, more importantly, the therapeutic response. It is therefore important to identify factors that distinguish one patient from another. Personalized therapy in DR is a new trend aimed at achieving maximum therapeutic response in patients by identifying genotypic and phenotypic factors that may result in less than optimal response to conventional therapy, and consequently, lead to poorer outcome. With advances in the identification of these genetic markers, such as gene polymorphisms and human leucocyte antigen associations, as well as development of drugs that can target their effects, the future of personalized medicine in DR is promising. In this comprehensive review, data from various studies have been analyzed to present what has been achieved in the field of pharmacogenomics thus far. An insight into future research is also provided

O percevejo bronzeado Thaumastocoris peregrinus: uma ameaça à eucaliptocultura mundial.

Resumo

Long-Term Benefit-Risk Profiles of Treatments for Moderate-to-Severe Plaque Psoriasis : A Network Meta-Analysis

Altres ajuts: AbbVie Inc.Introduction: The long-term benefit-risk profiles of licensed and investigational treatments for moderate-to-severe plaque psoriasis have not been fully characterized. Methods: Randomized controlled trials (RCTs) of licensed and investigational treatments for moderate-to-severe plaque psoriasis were identified through a systematic literature review through 2 May 2021. Bayesian network meta-analyses (NMAs) were conducted to compare the efficacy (Psoriasis Area and Severity Index [PASI] 75/90/100 [at least a 75/90/100% reduction in PASI score from baseline] response) and safety outcomes (any adverse event [AE], any serious AE [SAE], and AEs leading to treatment discontinuation) of each treatment evaluated between weeks 48 and 56 after baseline. Surfaces under the cumulative ranking curves (SUCRAs) were calculated to evaluate the relative ranking of treatments. The benefit-risk profiles of treatments were assessed by bidimensional plots of the NMA-estimated efficacy and safety outcomes. Results: In the efficacy NMA (N = 14 RCTs), the relative rankings for PASI 75/90/100 responses by weeks 48-56 were the highest for risankizumab (SUCRA: 98.5%) and bimekizumab (83.8% for dosing every 4 weeks [Q4W], 72.7% for dosing Q4W then every 8 weeks). The PASI response rates did not differ significantly between risankizumab and the two bimekizumab regimens. Additionally, risankizumab was associated with significantly higher PASI response rates than brodalumab, guselkumab, ixekizumab, secukinumab, ustekinumab, adalimumab, and etanercept. In the safety NMAs (N = 8 RCTs), risankizumab had the highest relative rankings for all three outcomes (SUCRA: 92.1%, 82.0%, and 91.0% for any AE, any SAE, and AEs leading to treatment discontinuation, respectively). Risankizumab had a significantly lower rate of any AE than bimekizumab, ustekinumab, and secukinumab. Conclusions: Risankizumab was associated with the most favorable long-term benefit-risk profile for the treatment of moderate-to-severe plaque psoriasis. Although ixekizumab and bimekizumab had favorable efficacy profiles, both treatments had lower rankings for safety outcomes

Влияние Магнитного Поля На Реологические Свойства Растворов Эфиров Целлюлозы

The rheological properties, structure and phase transitions of hydroxypropyl cellulose in ethanol, dimethyl sulfoxide, ethylene glycol solutions and ethylcellulose in dimethylformamide so-lutions are studied using viscometry, the cloud-point method, polarization microscopy, the optical interferometry and a polarization photoelectric apparatus in the temperature range 280-360 K. The temperature-concentration regions of isotropic and anisotropic phases are determined for all sys-tems. The type of boundary curves of phase diagrams is compared with the chemical structure of macromolecules. It is shown that the constant magnetic field (3.6 kOe) leads to the orientation of macromolecules in solutions. The domain structure arising in solutions is fixed after evaporation of a solvent and shown in orientation of strips of the film relief. It was found that the flow curves of all solutions at 298 K in the range of shear rates from 0 to 15 s-1 are typically for the non-Newtonian liquids. It was found that the magnetic field leads to an increase in the viscosity of isotropic solutions and a decrease in the viscosity of anisotropic solutions. Both effects depend on the direction of the magnetic field lines. When the rotor-rotation axis is parallel to the direction of power lines of the magnetic field the change in the viscosity of solutions is greater than that at perpendicular orientation of the rotor-rotation axis and power lines of the magnetic field. The re-sults are discussed using representations about the changes in the macromolecule conformation and in the size and shape of the supramolecular particles in the solutions during flow under a magnetic field with different orientation of the power lines © 2021, ChemChemTech. All Rights Reserved

2-(1,3-Benzothia­zol-2-yl)guanidine

In the title comound, C8H8N4S, one of the two independent mol­ecules is essentially planar (r.m.s. deviation = 0.025 Å), while the other is slightly buckled (r.m.s. deviation = 0.131 Å) with the guanidine unit bent out of the plane of the fused-ring system by 16.8 (1)°. In the crystal, inter­molecular N—H⋯N hydrogen bonds between the two independent mol­ecules give rise to a hydrogen-bonded dimer. Addtional weak inter­molecular N—H⋯N hydrogen bonds connect these dimers into chains along [010]. An intra­molecular N—H⋯N hydrogen bond is also observed in each independent mol­ecule