3,056 research outputs found
The immunohistochemical localization of alpha1-antichymotrypsin and fibronectin and its meaning for the determination of the vitality of human skin wounds
Mortality after infection with methicillin-resistant Staphylococcus aureus (MRSA) diagnosed in the community
<p>Abstract</p> <p>Background</p> <p>Outbreak reports suggest that community-acquired methicillin-resistant <it>Staphylococcus aureus </it>(MRSA) infections can be life-threatening. We conducted a population based cohort study to assess the magnitude of mortality associated with MRSA infections diagnosed in the community.</p> <p>Methods</p> <p>We used the United Kingdom's General Practice Research Database (GPRD) to form a cohort of all patients with MRSA diagnosed in the community from 2001 through 2004 and up to ten patients without an MRSA diagnosis. The latter were frequency-matched with the MRSA patients on age, GPRD practice and diagnosis date. All patients were older than 18 years, had no hospitalization in the 2 years prior to cohort entry and medical history information of at least 2 years prior to cohort entry. The cohort was followed up for 1 year and all deaths and hospitalizations were identified. Hazard ratios of all-cause mortality were estimated using the Cox proportional hazards model adjusted for patient characteristics.</p> <p>Results</p> <p>The cohort included 1439 patients diagnosed with MRSA and 14,090 patients with no MRSA diagnosis. Mean age at cohort entry was 70 years in both groups, while co-morbid conditions were more prevalent in the patients with MRSA. Within 1 year, 21.8% of MRSA patients died as compared with 5.0% of non-MRSA patients. The risk of death was increased in patients diagnosed with MRSA in the community (adjusted hazard ratio 4.1; 95% confidence interval: 3.5–4.7).</p> <p>Conclusion</p> <p>MRSA infections diagnosed in the community are associated with significant mortality in the year after diagnosis.</p
Background free search for neutrinoless double beta decay with GERDA Phase II
The Standard Model of particle physics cannot explain the dominance of matter
over anti-matter in our Universe. In many model extensions this is a very
natural consequence of neutrinos being their own anti-particles (Majorana
particles) which implies that a lepton number violating radioactive decay named
neutrinoless double beta () decay should exist. The detection
of this extremely rare hypothetical process requires utmost suppression of any
kind of backgrounds.
The GERDA collaboration searches for decay of Ge
(^{76}\rm{Ge} \rightarrow\,^{76}\rm{Se} + 2e^-) by operating bare detectors
made from germanium with enriched Ge fraction in liquid argon. Here, we
report on first data of GERDA Phase II. A background level of
cts/(keVkgyr) has been achieved which is the world-best if
weighted by the narrow energy-signal region of germanium detectors. Combining
Phase I and II data we find no signal and deduce a new lower limit for the
half-life of yr at 90 % C.L. Our sensitivity of
yr is competitive with the one of experiments with
significantly larger isotope mass.
GERDA is the first experiment that will be background-free
up to its design exposure. This progress relies on a novel active veto system,
the superior germanium detector energy resolution and the improved background
recognition of our new detectors. The unique discovery potential of an
essentially background-free search for decay motivates a
larger germanium experiment with higher sensitivity.Comment: 14 pages, 9 figures, 1 table; ; data, figures and images available at
http://www.mpi-hd.mpg/gerda/publi
Characterization of 30 Ge enriched Broad Energy Ge detectors for GERDA Phase II
The GERmanium Detector Array (GERDA) is a low background experiment located
at the Laboratori Nazionali del Gran Sasso in Italy, which searches for
neutrinoless double beta decay of Ge into Se+2e. GERDA has
been conceived in two phases. Phase II, which started in December 2015,
features several novelties including 30 new Ge detectors. These were
manufactured according to the Broad Energy Germanium (BEGe) detector design
that has a better background discrimination capability and energy resolution
compared to formerly widely-used types. Prior to their installation, the new
BEGe detectors were mounted in vacuum cryostats and characterized in detail in
the HADES underground laboratory in Belgium. This paper describes the
properties and the overall performance of these detectors during operation in
vacuum. The characterization campaign provided not only direct input for GERDA
Phase II data collection and analyses, but also allowed to study detector
phenomena, detector correlations as well as to test the strength of pulse shape
simulation codes.Comment: 29 pages, 18 figure
Limits on uranium and thorium bulk content in GERDA Phase I detectors
Internal contaminations of U, U and Th in the bulk of
high purity germanium detectors are potential backgrounds for experiments
searching for neutrinoless double beta decay of Ge. The data from GERDA
Phase~I have been analyzed for alpha events from the decay chain of these
contaminations by looking for full decay chains and for time correlations
between successive decays in the same detector. No candidate events for a full
chain have been found. Upper limits on the activities in the range of a few
nBq/kg for Ra, Ac and Th, the long-lived daughter
nuclides of U, U and Th, respectively, have been
derived. With these upper limits a background index in the energy region of
interest from Ra and Th contamination is estimated which
satisfies the prerequisites of a future ton scale germanium double beta decay
experiment.Comment: 2 figures, 7 page
decay of Ge into excited states with GERDA Phase I
Two neutrino double beta decay of Ge to excited states of Se
has been studied using data from Phase I of the GERDA experiment. An array
composed of up to 14 germanium detectors including detectors that have been
isotopically enriched in Ge was deployed in liquid argon. The analysis
of various possible transitions to excited final states is based on coincidence
events between pairs of detectors where a de-excitation ray is
detected in one detector and the two electrons in the other.
No signal has been observed and an event counting profile likelihood analysis
has been used to determine Frequentist 90\,\% C.L. bounds for three
transitions: : 1.6 yr,
: 3.7 yr and : 2.3 yr. These bounds are more
than two orders of magnitude larger than those reported previously. Bayesian
90\,\% credibility bounds were extracted and used to exclude several models for
the transition
Results on decay with emission of two neutrinos or Majorons in Ge from GERDA Phase I
A search for neutrinoless decay processes accompanied with
Majoron emission has been performed using data collected during Phase I of the
GERmanium Detector Array (GERDA) experiment at the Laboratori Nazionali del
Gran Sasso of INFN (Italy). Processes with spectral indices n = 1, 2, 3, 7 were
searched for. No signals were found and lower limits of the order of 10
yr on their half-lives were derived, yielding substantially improved results
compared to previous experiments with Ge. A new result for the half-life
of the neutrino-accompanied decay of Ge with significantly
reduced uncertainties is also given, resulting in yr.Comment: 3 Figure
Flux Modulations seen by the Muon Veto of the GERDA Experiment
The GERDA experiment at LNGS of INFN is equipped with an active muon veto.
The main part of the system is a water Cherenkov veto with 66~PMTs in the water
tank surrounding the GERDA cryostat. The muon flux recorded by this veto shows
a seasonal modulation. Two effects have been identified which are caused by
secondary muons from the CNGS neutrino beam (2.2 %) and a temperature
modulation of the atmosphere (1.4 %). A mean cosmic muon rate of /(sm) was found in good agreement with other experiments at
LNGS at a depth of 3500~meter water equivalent.Comment: 7 pages, 6 figure
Limit on the Radiative Neutrinoless Double Electron Capture of Ar from GERDA Phase I
Neutrinoless double electron capture is a process that, if detected, would
give evidence of lepton number violation and the Majorana nature of neutrinos.
A search for neutrinoless double electron capture of Ar has been
performed with germanium detectors installed in liquid argon using data from
Phase I of the GERmanium Detector Array (GERDA) experiment at the Gran Sasso
Laboratory of INFN, Italy. No signal was observed and an experimental lower
limit on the half-life of the radiative neutrinoless double electron capture of
Ar was established: 3.6 10 yr at 90 % C.I.Comment: 7 pages, 3 figure
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