Dynamics of Anti-Proton -- Protons and Anti-Proton -- Nucleus Reactions

A short review of simulation results of anti-proton-proton and anti-proton-nucleus interactions within the framework of Geant4 FTF (Fritiof) model is presented. The model uses the main assumptions of the Quark-Gluon-String Model or Dual Parton Model. The model assumes production and fragmentation of quark-anti-quark and diquark-anti-diquark strings in the mentioned interactions. Key ingredients of the model are cross sections of string creation processes and an usage of the LUND string fragmentation algorithm. They allow one to satisfactory describe a large set of experimental data, especially, a strange particle production, Lambda hyperons and K mesons.Comment: 7 pages, 8 figure

Simulation of neutron production in hadron-nucleus and nucleus-nucleus interactions in Geant4

Studying experimental data obtained at ITEP [1] on neutron production in interactions of protons with various nuclei in the energy range from 747 MeV up to 8.1 GeV, we have found that slow neutron spectra have scaling and asymptotic properties [2]. The spectra weakly depend on the collision energy at momenta of projectile protons larger than 5 - 6 GeV/c. These properties are taken into account in the Geant4 Fritiof (FTF) model. The improved FTF model describes as well as the Geant4 Bertini model the experimental data on neutron production by 1.2 GeV and 1.6 GeV protons on targets (Fe, Pb) [3] and by 3.0 GeV protons on various targets (Al, Fe, Pb) [4]. For neutron production in antiproton-nucleus interactions, it was demonstrated that the FTF results are in a satisfactory agreement with experimental data of the LEAR collaboration [5]. The FTF model gives promising results for neutron production in nucleus - nucleus interactions at projectile energy 1 - 2 GeV per nucleon [6]. The observed properties allow one to predict neutron yields in the nucleus-nucleus interactions at high and very high energies. Predictions for the NICA/MPD experiment at JINR are presented.Comment: 6 pages, 5 figures. Contribution to Proceedings of Baldin ISHEPP XXI

Production of strange particles in hadronic interactions

The NA61/SHINE collaboration has recently published high precision data on production of $\pi^\pm$ and $K^\pm$ mesons, protons, antiprotons and $\Lambda$ hyperons in ${\rm pp}$ interactions at 20, 31, 40, 80 and 158 GeV/c, and in ${\rm pC}$ interactions at 31 GeV/c. The collaboration also presented experimental data on production of particles - $\pi^\pm$, $K^\pm$, $p^\pm$, $\rho^0$, $\omega$ and $K^{*0}$ in $\pi^-{\rm C}$ collisions at 158 and 350 GeV/c. The collaboration has compared these data with various Monte Carlo model calculations: UrQMD, EPOS, GiBUU, and others. All of the models have various problems. The latest version of the FTF (Fritiof) model of Geant4 solves most of these problems. In the FTF model, we have improved the fragmentation of quark-gluon strings with small masses and introduced dependencies of probabilities of strange mesons and baryon-antibaryon pair's creation on string masses. Due to these changes, we describe the data of the NA61/SHINE collaboration on particle production in ${\rm pp, pC}$, and $\pi^-{\rm C}$ interactions. The improved Geant4 FTF model also well reproduces experimental data on inclusive cross sections of $\Lambda, \bar{\Lambda}$ and $K^{0}$ production in antiproton-proton interactions at various energies. The modified FTF model allows one to simulate realistic processes with two particle productions - $\bar{p}p \rightarrow \Lambda \bar{\Lambda}$, $\bar{p}p \rightarrow K^{+} K^{-}$, $\bar{p}p \rightarrow \Lambda \bar{\Sigma}$, and $\bar{p}p \rightarrow\Sigma \bar{\Sigma}$, which will be studied in the future by the PANDA experiment at FAIR (GSI, Germany).Comment: 10 pages, 8 figures, IWNT-37, Rila, 2018, Bulgari

Geant4 FTF model description of the latest data by the NA61/SHINE collaboration on 40Ar+45Sc{\rm ^{40}Ar+{}^{45}Sc} interactions

It is shown that the Geant4 FTF model, which does not include the simulation of the hard parton-parton scattering and the formation of the quark-gluon plasma (QGP), describes well the NA61/SHINE data on $\pi^-$ meson distributions for the interactions at $\sqrt{s_{NN}}=$ 5.2, 6.1, 7.6 and 8.8 GeV. At higher energies, $\sqrt{s_{NN}}=$ 11.9 and 16.8 GeV, the model underestimates the data. This is considered as an indication of the formation of QGP at higher energies in central collisions of light and intermediate nuclei than in collisions of heavy nuclei ($\sqrt{s_{NN}}\sim 6$ GeV).Comment: 5 pages, 2 figure

Epidemiología molecular de la tuberculosis: métodos y aplicaciones

The resurgence of tuberculosis around the world has renewed interest in understanding the epidemiology and pathogenesis of this disease. A revolutionary advance in the field of tuberculosis research has been the development of molecular techniques that permit identification and tracking of individual strains of Mycobacterium tuberculosis. With these techniques, molecular epidemiology has been established as a new discipline that adds another dimension to the classical epidemiology of tuberculosis and has increased our understanding of the transmission dynamics of M. tuberculosis. The increased epidemiological knowledge has led to discovery of inadequacies in tuberculosis control programs; this information has helped garner resources for program improvement and has highlighted the need for the continuous surveillance of tuberculosis. Additional genetic methods are being developed based on the knowledge of the genome sequence of M. tuberculosis. These simpler and less costly genotyping techniques promise to expand the application of molecular epidemiology to developing nations (where 90% of the disease burden occurs) in support of national tuberculosis programs. Furthermore, these tools permit ever more effective probes into the dynamics of transmission, the population structure, evolution and pathogenesis of M. tuberculosis.La reemergencia de la tuberculosis en el mundo ha despertado el interés en el entendimiento de la epidemiología y patogénesis de esta enfermedad. Un revolucionario avance en este campo de investigación ha sido el desarrollo de técnicas moleculares que permiten identificar y establecer la huella particular de cada cepa de M. tuberculosis. Con el uso de estas técnicas, y el establecimiento de la epidemilogia molecular como nueva disciplina se adicionó otra dimensión a la epidemiologia clásica de la tuberculosis y ha incrementado el conocimiento de la dinámica de la transmisión de M. tuberculosis dentro de una población. En el proceso han sido identificados problemas en los programas de control, lo cual ha ayudado a obtener recursos para su mejoramineto e implementación. Aún más, se ha resaltado la necesidad de continuar vigilando esta enfermedad. Otras metodologías genotípicas han sido desarrolladas a partir del conocimiento de la secuencia del genoma de M. tuberculosis. Estas metodologías genotípicas de fácil implementación y bajo costo se deben aplicar en países en vía de desarrollo, donde existe el 90% de la enfermedad, como apoyo a los programas de control de la tuberculosis. Estas herramientas permitirán conocer la dinámica de transmisión de la tuberculosis, la estructura de la población, la evolución y patogénesis de M. tuberculosis

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

Insulin stimulates the transport of glucose into fat and muscle cells. Although the precise molecular mechanisms involved in this process remain uncertain, insulin initiates its actions by binding to its tyrosine kinase receptor, leading to the phosphorylation of intracellular substrates. One such substrate is the Cbl protooncogene product(1). Cbl is recruited to the insulin receptor by interaction with the adapter protein CAP, through one of three adjacent SH3 domains in the carboxy terminus of CAP(2). Upon phosphorylation of Cbl, the CAP-Cbl complex dissociates from the insulin receptor and moves to a caveolin-enriched, triton-insoluble membrane fraction(3). Here, to identify a molecular mechanism underlying this subcellular redistribution, we screened a yeast two-hybrid library using the amino-terminal region of CAP and identified the caveolar protein flotillin. Flotillin forms a ternary complex with CAP and Cbl, directing the localization of the CAP-Cbl complex to a lipid raft subdomain of the plasma membrane. Expression of the N-terminal domain of CAP in 3T3-L1 adipocytes blocks the stimulation of glucose transport by insulin, without affecting signalling events that depend on phosphatidylinositol-3-OH kinase. Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62940/1/407202a0.pd

Gel mobility shift scanning of pectin-inducible promoter from Penicillium griseoroseum reveals the involvement of a CCAAT element in the expression of a polygalacturonase gene

Previous reports have described pgg2, a polygalacturonase-encoding gene of Penicillium griseoroseum, as an attractive model for transcriptional regulation studies, due to its high expression throughout several in vitro growth conditions, even in the presence of non-inducing sugars such as sucrose. A search for regulatory motifs in the 5' upstream regulatory sequence of pgg2 identified a putative CCAAT box that could justify this expression profile. This element, located 270 bp upstream of the translational start codon, was tested as binding target for regulatory proteins. Analysis of a 170 bp promoter fragment by electrophoretic mobility shift assay (EMSA) with nuclear extracts prepared from mycelia grown in pectin-containing culture medium revealed a high mobility complex that was subsequently confirmed by analyzing it with a double-stranded oligonucleotide spanning the CCAAT motif. A substitution in the core sequence for GTAGG partially abolished the formation of specific complexes, showing the involvement of the CCAAT box in the regulation of the polygalacturonase gene studied

Heavy Flavours in Collider Experiments

Current issues in the studies of Heavy Flavours in colliders are described with particular emphasis on experiments in which the UK is involved. Results on charm production at HERA are examined and compared to those at the Tevatron. B production rates at the Tevatron as well as the status of B lifetimes and mixing in the LEP collaborations and at the Tevatron are highlighted. The measurement of sin2beta from CDF is described as well as the most recent results on top physics at the Tevatron

CAP interacts with cytoskeletal proteins and regulates adhesion‐mediated ERK activation and motility

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102140/1/emboj7601406-sup-0001.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102140/2/emboj7601406.pd

GeantV: Results from the prototype of concurrent vector particle transport simulation in HEP

Full detector simulation was among the largest CPU consumer in all CERN experiment software stacks for the first two runs of the Large Hadron Collider (LHC). In the early 2010's, the projections were that simulation demands would scale linearly with luminosity increase, compensated only partially by an increase of computing resources. The extension of fast simulation approaches to more use cases, covering a larger fraction of the simulation budget, is only part of the solution due to intrinsic precision limitations. The remainder corresponds to speeding-up the simulation software by several factors, which is out of reach using simple optimizations on the current code base. In this context, the GeantV R&D project was launched, aiming to redesign the legacy particle transport codes in order to make them benefit from fine-grained parallelism features such as vectorization, but also from increased code and data locality. This paper presents extensively the results and achievements of this R&D, as well as the conclusions and lessons learnt from the beta prototype.Comment: 34 pages, 26 figures, 24 table