On Operational Earthquake Forecast and Prediction Problems.

In his SSA presidential address (Jordan, 2014), and later in a more extended publication with coauthors (Jordan et al., 2014), Jordan presents a vision of forecast and prediction problems of earthquake system science. As experienced practitioners and in full appreciation of scientific studies on earthquake forecasting, we find it necessary to share a complementary viewpoint

Simulation of the 2009, Mw = 4 Tehran earthquake using a hybrid method of modal summation and finite difference

The Greater Tehran Area is the most important city of Iran and hosts about 20% of the country?s population. Despite the presence of major faults and the occurrence of historical earthquakes, the seismicity is relatively low at present. Thus, it is important to estimate the ground motion for preventive, reliable seismic hazard assessment. An earthquake with magnitude Mw = 4, which occurred close to Tehran, 17 October 2009, is the first local earthquake that has been recorded by the local strong ground motion network in Tehran. To simulate the ground motion caused by the earthquake a hybrid technique is used. It combines two methods: the analytical modal summation and the numerical finite difference, taking advantage of the merits of both. The modal summation is applied to simulate wave propagation from the source to the sedimentary basin and finite difference to propagate the incoming wavefield in the laterally heterogeneous part of the structural model that contains the sedimentary basin. Synthetic signals are simulated along two East?West and Southeast?Northwest profiles. Frequency, response spectra, and time domain, waveforms and peak values, parameters are computed synthetically and compared with observed records. Results show agreement between observed and simulated signals. The simulation shows local site amplification as high as 6 in the southern part of Tehran

ACOUSTIC ANALYSIS OF SWALLOWING SOUNDS: A NEW TECHNIQUE FOR ASSESSING DYSPHAGIA

Objective: To perform acoustic analysis of swallowing sounds, using a microphone and a notebook computer system, in healthy subjects and patients with dysphagia affected by neurological diseases, testing the positive/negative predictive value of a pathological pattern of swallowing sounds for penetration/aspiration. Design: Diagnostic test study, prospective, not blinded, with the penetration/aspiration evaluated by fibreoptic endo scopy of swallowing as criterion standard. Subjects: Data from a previously recorded database of normal swallowing sounds for 60 healthy subjects according to gender, age, and bolus consistency was compared with those of 15 patients with dysphagia from a university hospital referral centre who were affected by various neurological diseases. Methods: Mean duration of the swallowing sounds and postswallowing apnoea were recorded. Penetration/aspiration was verified by fibreoptic endoscopy of swallowing in all patients with dysphagia. Results: The mean duration of swallowing sounds for a liquid bolus of 10 ml water was significantly different between patients with dysphagia and healthy patients. We also described patterns of swallowing sounds and tested the negative/positive predictive values of post-swallowing apnoea for penetration/aspiration verified by fibreoptic endoscopy of swallowing (sensitivity 0.67 (95% confidence interval 0.24–0.94); specificity 1.00 (95% confidence interval 0.56–1.00)). Conclusion: The proposed technique for recording and measuring swallowing sounds could be incorporated into the bedside evaluation, but it should not replace the use of more diagnostic and valuable measures

effect of intrathecal baclofen botulinum toxin type a and a rehabilitation programme on locomotor function after spinal cord injury a case report

Objective: a few studies have reported the use of botulinum toxin injections after spinal cord injury, as this is the gold standard to treat focal spasticity. We report such a case here. Case report: a 38-year-old woman who had become paraplegic and care-dependent secondary to cervico-thoracic intramedullary ependymoma, presented 8 months later with painful lower limb spasticity, which was being treated with oral anti-spastic and benzodiazepine drugs with no therapeutic effect. We treated the patient with intrathecal baclofen to reduce her spasticity and in order to avoid the major side-effects of high dosages of oral baclofen. after motor rehabilitation programmes, which included functional ele

Efficient management of industrial electric vehicles by means of static and dynamic wireless power transfer systems

Industrial companies are moving toward the electrification of equipment and processes, in line with the broader energy transition taking place across the economy. Particularly, the energy efficiency and, consequently, the reduction of environmental pollution of intralogistics activities have become a competitive element and are now an actual research and development objective. A wireless power transfer is a contactless electrical energy transmission technology based on the magnetic coupling between coils installable under the ground level and a coil mounted under the vehicle floor, and it represents an excellent solution to decrease the demand for batteries by reducing vehicle downtimes during the recharge. This work aims to define a methodology to determine the optimal positioning of wireless charging units across the warehouse, both for static and dynamic recharging. To this aim, firstly, a mathematical model of the warehouse is proposed to describe transfers and storage/retrieval operations executed by the forklifts. Then, an integer linear programming problem is applied to find the best possible layout of the charging infrastructures. The optimal solution respects the energetic requirements given by the customer and minimizes the overall system cost. The proposed approach was applied to optimize the installation in a real-size warehouse of a tire manufacturing company. Several scenarios were computer generated through discrete event simulation in order to test the optimizer in different warehouse conditions. The obtained results show that integrated dynamic and static WPT systems ensure a constant state of charge of the electric vehicles during their operations

effectiveness of switching therapy from complexing protein containing botulinum toxin type a to a formulation with low immunogenicity in spasticity after stroke a case report

Objective: some patients receiving botulinum toxin type a therapy develop immunological resistance due to the production of neutralizing antibodies against the neurotoxin, thus partially or completely reducing the therapeutic effect. Case report: We report here neurophysiological and clinical findings for a 58-year-old man treated with botulinum toxin type A for spasticity after ischaemic stroke, who became a secondary non-responder patient. subsequent treatment with a different preparation of botulinum toxin type A had a great therapeutic effect on his spasticity. the muscles injected and the dosages were the same for each treatment, but evaluation with the Modified Ashworth Scale after treatment with the second preparation showed a reduction of approximately 2 points compared with the first examination. The clinical results were also supported by extensor digitorum brevis testing of the right muscle, which showed a reduction in compound muscle action potential, whereas it was unchanged in the non-injected muscle. No side-effects were reported, and after 1 year of treatment with this formulation clinical benefits were still evident. Conclusion: the neurophysiological and clinical results obtained in this patient suggest that switching therapy from a complexing protein-containing product to a product potentially free of complexing proteins, which has low immunogenicity, may be a viable therapeutic option in secondary non-responder patients

Vascular risk and genetics of sporadic late-onset Alzheimer's disease.

In recent years, it is becoming apparent that genes may play an important role in the development of late-onset Alzheimer’s disease (LOAD), and genetic studies could unravel new clues. Based on a growing vascular hypothesis for the pathogenesis of LOAD and other dementias, there is increasing interest for environmental and genetic vascular factors. Polymorphisms in different susceptibility genes already implicated in vascular disease risk are now also being suggested as possible genetic markers for increased risk of developing LOAD; however, many of these studies have shown conflicting results. Thus far, the apolipoprotein E (APOE) gene seems to be the only vascular susceptibility factor that is agreed to play a role in the multifactorial pathogenesis of AD although emerging genetic and biological evidence is now strengthening the case for additional inclusion of angiotensin I-converting enzyme 1 (ACE1) into this category. This review will focus on the current knowledge on genetic and nongenetic vascular factors likely to be involved in LOAD, with special emphasis placed on the APOE and ACE1 genes

Seguridad del Paciente Oncológico : Desarrollos Estratégicos

Los errores en el tratamiento quimioterápico pueden tener consecuencias graves para los pacientes debido al estrecho margen terapéutico de los antineoplásicos; la mayor parte de los errores de medicación están sujetos al error humano. El objetivo de este trabajo es describir las estrategias utilizadas por el Sanatorio Güemes para mejorar la seguridad en el tratamiento de pacientes oncológicos sobre la base de desarrollos de recursos electrónicos y estandarización de procedimientos. La implementación de estas estrategias representó una disminución en la probabilidad de error con un cambio en el estándar de calidad y seguridad de atención al paciente, logrando además optimización de recursos y tiempos.Sociedad Argentina de Informática e Investigación Operativ

Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians.

Vascular factors may play a role in the etiology of Alzheimer’s disease (AD) and increased serum apolipoprotein E (APOE) levels in AD could be of interest, as APOE concentration is associated with vascular disease. Aims of this study were to evaluate the inluence of APOE genotype on serum APOE levels, and, secondly, to study serum APOE concentrations in relation to age and AD. APOE genotypes, serum total cholesterol, LDL cholesterol, HDL cholesterol, total cholesterol/HDL cholesterol ratio, triglycerides, and serum APOE were performed on 52 healthy centenarians, 49 AD patients, 45 age-matched controls, and 72 young healthy adults. In all study population a significant trend in reduction of serum APOE levels from APOE E2- to E4 carriers was observed.The diffeerence in serumAPOE levels amonga ge groups signi¢cantly decreased in E4 carriers only, includingH DL cholesterol; no significant differences between AD patients and age-matched controls were found. In these highly selected populations, APOE genotype distribution strongly influences serum APOE concentration, not suggesting, at present, a possible role as a biochemical marker for AD, but only as a putative longevity factor