964 research outputs found
Discretized vs. continuous models of p-wave interacting fermions in 1D
We present a general mapping between continuous and lattice models of Bose-
and Fermi-gases in one dimension, interacting via local two-body interactions.
For s-wave interacting bosons we arrive at the Bose-Hubbard model in the weakly
interacting, low density regime. The dual problem of p-wave interacting
fermions is mapped to the spin-1/2 XXZ model close to the critical point in the
highly polarized regime. The mappings are shown to be optimal in the sense that
they produce the least error possible for a given discretization length. As an
application we examine the ground state of a interacting Fermi gas in a
harmonic trap, calculating numerically real-space and momentum-space
distributions as well as two-particle correlations. In the analytically known
limits the convergence of the results of the lattice model to the continuous
one is shown.Comment: 7 pages, 5 figure
Prediction with Expert Advice under Discounted Loss
We study prediction with expert advice in the setting where the losses are
accumulated with some discounting---the impact of old losses may gradually
vanish. We generalize the Aggregating Algorithm and the Aggregating Algorithm
for Regression to this case, propose a suitable new variant of exponential
weights algorithm, and prove respective loss bounds.Comment: 26 pages; expanded (2 remarks -> theorems), some misprints correcte
Risk profiling and efficacy of albendazole against the hookworms Necator americanus and Ancylostoma ceylanicum in Cambodia to support control programs in Southeast Asia and the Western Pacific
Background: Hookworm disease is endemic throughout many parts of the Asia Pacific, despite targeted control programs of at-risk populations. The success of these programs has been hindered by the limited efficacy of widely-used mebendazole, rapid re-infection rates linked to persistent reservoirs of untreated people and dogs, and the low sensitivity of conventional coprodiagnostic techniques employed. Methods: Here, we used standard faecal flotation (SFF) and a multiplex qPCR (mqPCR) assay to calculate and compare species-specific cure and egg reduction rates of single dose albendazole (400 mg) against hookworm infections at community level. Data from a cross-sectional survey in 1,232 people from Cambodia were used to inform a generalised linear mixed model to identify risk factors linked to hookworm infection(s) at baseline. Furthermore, we calculated risk factors associated to the probability of being cured after albendazole administration. Findings: Overall, 13.5% of all 1,232 people tested by SFF were positive for hookworm infection(s). Most (80.1%) infected people were >12 years of age, hence above the age targeted by the WHO control program. We estimate that as age increases, the odds of being infected increases at a faster rate for females than for males. We revealed a substantial difference in cure rate of hookworm infection(s) following albendazole treatment using the SFF (81.5%) and mqPCR (46.4%) assays, and provide the first data on the efficacy of this drug against the zoonotic hookworm Ancylostoma ceylanicum. We estimated that as age increases by one year, the odds of being cured decreases by 0.4%-3.7%. Similarly, the odds of being cured for people who boiled drinking water was estimated to be between 1.02 and 6.82. Interpretation: These findings show that the adoption of refined diagnostic techniques is central to monitoring hookworm infection(s) and the success of control strategies, which can ultimately aid in reducing associated morbidity in human populations. The approach taken is likely to be directly applicable to other parts of Southeast Asia and the Western Pacific, where specific epidemiological conditions might hamper the success of targeted treatment programs. Funding: Faculty of Veterinary and Agricultural Sciences Strategic Research Funds, The University of Melbourne
Spatio-temporal Fermionization of Strongly Interacting 1D Bosons
Building on the recent experimental achievements obtained with scanning
electron microscopy on ultracold atoms, we study one-dimensional Bose gases in
the crossover between the weakly (quasi-condensate) and the strongly
interacting (Tonks-Girardeau) regime. We measure the temporal two-particle
correlation function and compare it with calculations performed using the Time
Evolving Block Decimation algorithm. More pronounced antibunching is observed
when entering the more strongly interacting regime. Even though this mimics the
onset of a fermionic behavior, we highlight that the exact and simple duality
between 1D bosons and fermions does not hold when such dynamical response is
probed. The onset of fermionization is also reflected in the density
distribution, which we measure \emph{in situ} to extract the relevant
parameters and to identify the different regimes. Our results show agreement
between experiment and theory and give new insight into the dynamics of
strongly correlated many-body systems
Reflection of a Lieb-Liniger wave packet from the hard-wall potential
Nonequilibrium dynamics of a Lieb-Liniger system in the presence of the
hard-wall potential is studied. We demonstrate that a time-dependent wave
function, which describes quantum dynamics of a Lieb-Liniger wave packet
comprised of N particles, can be found by solving an -dimensional Fourier
transform; this follows from the symmetry properties of the many-body
eigenstates in the presence of the hard-wall potential. The presented formalism
is employed to numerically calculate reflection of a few-body wave packet from
the hard wall for various interaction strengths and incident momenta.Comment: revised version, improved notation, Fig. 5 adde
Matrix product decomposition and classical simulation of quantum dynamics in the presence of a symmetry
We propose a refined matrix product state representation for many-body
quantum states that are invariant under SU(2) transformations, and indicate how
to extend the time-evolving block decimation (TEBD) algorithm in order to
simulate time evolution in an SU(2) invariant system. The resulting algorithm
is tested in a critical quantum spin chain and shown to be significantly more
efficient than the standard TEBD.Comment: 5 pages, 4 figure
The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs)
Citrullination is the post-translational hydrolysis of peptidyl-arginines to form peptidyl-citrulline, a reaction that is catalyzed by the protein arginine deiminases (PADs), a family of calcium-regulated enzymes. Aberrantly increased protein citrullination is associated with a slew of autoimmune diseases (e.g., rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis) and certain cancers. Given the clear link between increased PAD activity and human disease, the PADs are therapeutically relevant targets. Herein, we report the development of next generation cell permeable and clickable probes (BB-Cl-Yne and BB-F-Yne) for covalent labeling of the PADs both in vitro and in cell-based systems. Using advanced chemoproteomic technologies, we also report the off targets of both BB-Cl-Yne and BB-F-Yne. The probes are highly specific for the PADs, with relatively few off targets, especially BB-F-Yne, suggesting the preferential use of the fluoroacetamidine warhead in next generation irreversible PAD inhibitors. Notably, these compounds can be used in a variety of modalities, including the identification of off targets of the parent compounds and as activity-based protein profiling probes in target engagement assays to demonstrate the efficacy of PAD inhibitors
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