Advances in Research with LGBTQ Youth in Schools

Over the past decade, there has been an increase in scholarship devoted to the topic of sexual and gender minority youth in schools (e.g., lesbian, gay, bisexual, transgender, queer, or questioning; LGBTQ). In this special section, we highlight this group of LGBTQ youth, a group that needs as many allies as possible, a group that lacks the social standing, the financial capital necessary, and the rights afforded to adults to directly influence the political climate in ways that affect their lives. Collectively, these seven data-driven articles are reflective of the innovation that is occurring in our field as we continue to study the experiences of LGBTQ youth in schools. They also highlight how there is room to expand our research efforts to better ensure that the social, educational, and developmental needs of LGBTQ students are met by our schools

Changing Voting Patterns in the Burger Court: The Impact of Personnel Change

This Article investigates the impact of personnel change in the Supreme Court. The author examines the transition from the Warren Court to the Burger Court, the broader implications this has on the nature of change in the Court and on the relationship between the Court and the broader political system. The author suggests that each change in the membership of the Court during this period altered the Court\u27s internal voting patterns. The author argues that President Nixon was successful in appointing justices to slow the libertarian drive of the late Warren Court. The author concludes that this illustrates that a president blessed with sufficient vacancies has substantial, but not unlimited, capacity to reshape the Court through the exercise of appointment power

Justice Brennan and Freedom of Expression Doctrine in the Burger Court

This Article examines Justice Brennan\u27s voting record and opinions in first amendment cases decided since 1969 and compares Justice Brennan\u27s votes to those of his colleagues on the Burger Court. The author investigates the major themes that run through Justice Brennan\u27s opinions in an attempt to ascertain whether Justice Brennan\u27s votes are rooted in a coherent doctrine of freedom of expression, and whether he has moved away from his reliance on the functional view of the first amendment. The author concludes that Justice Brennan has developed an approach that combines a conservative approach to freedom of expression with a more liberal natural rights approach

Gay-Straight Alliances as Settings to Discuss Health Topics: Individual and Group Factors Associated with Substance Use, Mental Health, and Sexual Health Discussions

Sexual minority (e.g. lesbian, gay, bisexual, questioning; LGBQ) and gender minority (e.g. transgender) youth experience myriad health risks. Gay-Straight Alliances (GSAs) are school-based settings where they may have opportunities to discuss substance use, mental health, and sexual health issues in ways that are safe and tailored to their experiences. Attention to these topics in GSAs could aid in developing programming for these settings. Among 295 youth from 33 Massachusetts high-school GSAs (69% LGBQ, 68% cisgender female, 68% White, Mage = 16.06), we examined how often youth discussed these topics within their GSA and identified factors associated with having more of these discussions. Youth and GSAs as a whole varied in their frequency of discussing these topics. Youth who accessed more information/resources in the GSA and did more advocacy more frequently engaged in discussions around substance use, mental health and sexual health. Youth who reported greater victimization more often discussed substance use and mental health, but not sexual health. Finally, GSAs whose members collectively reported greater victimization more frequently discussed these topics. These findings can assist the development of health programming to be delivered within GSAs

Using {\sc top-c} for Commodity Parallel Computing in Cosmic Ray Physics Simulations

{\sc top-c} (Task Oriented Parallel C) is a freely available package for parallel computing. It is designed to be easy to learn and to have good tolerance for the high latencies that are common in commodity networks of computers. It has been successfully used in a wide range of examples, providing linear speedup with the number of computers. A brief overview of {\sc top-c} is provided, along with recent experience with cosmic ray physics simulations.Comment: Talk to be presented at the XI International Symposium on Very High Energy Cosmic Ray Interaction

Topologically protected charge transfer along the edge of a chiral p\textit{p}-wave superconductor

The Majorana fermions propagating along the edge of a topological superconductor with $p_x+ip_y$ pairing deliver a shot noise power of $\frac{1}{2}\times e^2/h$ per eV of voltage bias. We calculate the full counting statistics of the transferred charge and find that it becomes trinomial in the low-temperature limit, distinct from the binomial statistics of charge-$e$ transfer in a single-mode nanowire or charge-$2e$ transfer through a normal-superconductor interface. All even-order correlators of current fluctuations have a universal quantized value, insensitive to disorder and decoherence. These electrical signatures are experimentally accessible, because they persist for temperatures and voltages large compared to the Thouless energy.Comment: 5 pages, 4 figures. v3 [post-publication]: added an appendix on the effect of a tunnel barrier at the normal-superconductor contac

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice

Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing, resulting in degenerative processes affecting preferentially cerebellar neurons. As a faithful animal model, we generated a knock-in mouse replacing the single CAG of murine Atxn2 with CAG42, a frequent patient genotype. This expansion size was inherited stably. The mice showed phenotypes with reduced weight and later motor incoordination. Although brain Atxn2 mRNA became elevated, soluble ATXN2 protein levels diminished over time, which might explain partial loss-of-function effects. Deficits in soluble ATXN2 protein correlated with the appearance of insoluble ATXN2, a progressive feature in cerebellum possibly reflecting toxic gains-of-function. Since in vitro ATXN2 overexpression was known to reduce levels of its protein interactor PABPC1, we studied expansion effects on PABPC1. In cortex, PABPC1 transcript and soluble and insoluble protein levels were increased. In the more vulnerable cerebellum, the progressive insolubility of PABPC1 was accompanied by decreased soluble protein levels, with PABPC1 mRNA showing no compensatory increase. The sequestration of PABPC1 into insolubility by ATXN2 function gains was validated in human cell culture. To understand consequences on mRNA processing, transcriptome profiles at medium and old age in three different tissues were studied and demonstrated a selective induction of Fbxw8 in the old cerebellum. Fbxw8 is encoded next to the Atxn2 locus and was shown in vitro to decrease the level of expanded insoluble ATXN2 protein. In conclusion, our data support the concept that expanded ATXN2 undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissuespecific effects, which may be partially alleviated by the induction of FBXW8

Impacts devalue the potential of large-scale terrestrial CO2 removal through biomass plantations

Large-scale biomass plantations (BPs) are often considered a feasible and safe climate engineering proposal for extracting carbon from the atmosphere and, thereby, reducing global mean temperatures. However, the capacity of such terrestrial carbon dioxide removal (tCDR) strategies and their larger Earth system impacts remain to be comprehensively studied—even more so under higher carbon emissions and progressing climate change. Here, we use a spatially explicit process-based biosphere model to systematically quantify the potentials and trade-offs of a range of BP scenarios dedicated to tCDR, representing different assumptions about which areas are convertible. Based on a moderate CO2 concentration pathway resulting in a global mean warming of 2.5 °C above preindustrial level by the end of this century—similar to the Representative Concentration Pathway (RCP) 4.5—we assume tCDR to be implemented when a warming of 1.5 °C is reached in year 2038. Our results show that BPs can slow down the progression of increasing cumulative carbon in the atmosphere only sufficiently if emissions are reduced simultaneously like in the underlying RCP4.5 trajectory. The potential of tCDR to balance additional, unabated emissions leading towards a business-as-usual pathway alike RCP8.5 is therefore very limited. Furthermore, in the required large-scale applications, these plantations would induce significant trade-offs with food production and biodiversity and exert impacts on forest extent, biogeochemical cycles and biogeophysical properties