A fatal case of oxygen embolism in a hospital

This case reports on a 68-year-old man who was found dead in hospital next to his bed. Before this, he had been treated with intravenous antibiotics for pneumonia. The body was found with a peripheral venous catheter connected to a nasal cannula delivering oxygen (O2) from the wall. Extensive medico–legal examinations were performed, including post-mortem computed tomography (CT), complete conventional autopsy, histological and immunohistochemistry analysis, toxicological analysis and post-mortem chemistry. Additionally, CT-guided gas sampling was performed at multiple sites to collect samples for gas analysis. During the external examination, massive subcutaneous emphysema was visible over the entire surface of the body. The CT scan revealed the presence of gas throughout the vascular system, and in the subcutaneous and muscular tissues. The autopsy confirmed the presence of lobar pneumonia and multiple gas bubbles in the vascular system. The gas analysis results showed a subnormal concentration of oxygen, confirming the suspected pure O2 embolism. Moreover, the carbon dioxide (CO2) concentration in the gas sample from the heart was elevated to a level similar to those found in scuba diving fatalities. This could come from degassing of dissolved CO2 that accumulated and was trapped in the cardiac cavity. Based on the results of the different exams performed, and especially the gas analysis results, it was concluded that the cause of death was O2 embolism

Ground-based follow-up observations of TRAPPIST-1 transits in the near-infrared

The TRAPPIST-1 planetary system is a favorable target for the atmospheric characterization of temperate earth-sized exoplanets by means of transmission spectroscopy with the forthcoming James Webb Space Telescope (JWST). A possible obstacle to this technique could come from the photospheric heterogeneity of the host star that could affect planetary signatures in the transit transmission spectra. To constrain further this possibility, we gathered an extensive photometric data set of 25 TRAPPIST-1 transits observed in the near-IR J band (1.2 $\mu$m) with the UKIRT and the AAT, and in the NB2090 band (2.1 $\mu$m) with the VLT during the period 2015-2018. In our analysis of these data, we used a special strategy aiming to ensure uniformity in our measurements and robustness in our conclusions. We reach a photometric precision of $\sim0.003$ (RMS of the residuals), and we detect no significant temporal variations of transit depths of TRAPPIST-1 b, c, e, and g over the period of three years. The few transit depths measured for planets d and f hint towards some level of variability, but more measurements will be required for confirmation. Our depth measurements for planets b and c disagree with the stellar contamination spectra originating from the possible existence of bright spots of temperature 4500 K. We report updated transmission spectra for the six inner planets of the system which are globally flat for planets b and g and some structures are seen for planets c, d, e, and f.Comment: accepted for publication in MNRA

Monte Carlo Simulations Suggest Current Chlortetracycline Drug-Residue Based Withdrawal Periods Would Not Control Antimicrobial Resistance Dissemination from Feedlot to Slaughterhouse

Antimicrobial use in beef cattle can increase antimicrobial resistance prevalence in their enteric bacteria, including potential pathogens such as Escherichia coli. These bacteria can contaminate animal products at slaughterhouses and cause food-borne illness, which can be difficult to treat if it is due to antimicrobial resistant bacteria. One potential intervention to reduce the dissemination of resistant bacteria from feedlot to consumer is to impose a withdrawal period after antimicrobial use, similar to the current withdrawal period designed to prevent drug residues in edible animal meat. We investigated tetracycline resistance in generic E. coli in the bovine large intestine during and after antimicrobial treatment by building a mathematical model of oral chlortetracycline pharmacokinetics-pharmacodynamics and E. coli population dynamics. We tracked three E. coli subpopulations (susceptible, intermediate, and resistant) during and after treatment with each of three United States chlortetracycline indications (liver abscess reduction, disease control, disease treatment). We compared the proportion of resistant E. coli before antimicrobial use to that at several time points after treatment and found a greater proportion of resistant enteric E. coli after the current withdrawal periods than prior to treatment. In order for the proportion of resistant E. coli in the median beef steer to return to the pre-treatment level, withdrawal periods of 15 days after liver abscess reduction dosing (70 mg daily), 31 days after disease control dosing (350 mg daily), and 36 days after disease treatment dosing (22 mg/kg bodyweight for 5 days) are required in this model. These antimicrobial resistance withdrawal periods would be substantially longer than the current U.S. withdrawals of 0–2 days or Canadian withdrawals of 5–10 days. One published field study found similar time periods necessary to reduce the proportion of resistant E. coli following chlortetracycline disease treatment to those suggested by this model, but additional carefully designed field studies are necessary to confirm the model results. This model is limited to biological processes within the cattle and does not include resistance selection in the feedlot environment or co-selection of chlortetracycline resistance following other antimicrobial use

An eclipsing substellar binary in a young triple system discovered by SPECULOOS

Mass, radius, and age are three of the most fundamental parameters for celestial objects, enabling studies of the evolution and internal physics of stars, brown dwarfs, and planets. Brown dwarfs are hydrogen-rich objects that are unable to sustain core fusion reactions but are supported from collapse by electron degeneracy pressure. As they age, brown dwarfs cool, reducing their radius and luminosity. Young exoplanets follow a similar behaviour. Brown dwarf evolutionary models are relied upon to infer the masses, radii and ages of these objects. Similar models are used to infer the mass and radius of directly imaged exoplanets. Unfortunately, only sparse empirical mass, radius and age measurements are currently available, and the models remain mostly unvalidated. Double-line eclipsing binaries provide the most direct route for the absolute determination of the masses and radii of stars. Here, we report the SPECULOOS discovery of 2M1510A, a nearby, eclipsing, double-line brown dwarf binary, with a widely-separated tertiary brown dwarf companion. We also find that the system is a member of the $45\pm5$ Myr-old moving group, Argus. The system's age matches those of currently known directly-imaged exoplanets. 2M1510A provides an opportunity to benchmark evolutionary models of brown dwarfs and young planets. We find that widely-used evolutionary models do reproduce the mass, radius and age of the binary components remarkably well, but overestimate the luminosity by up to 0.65 magnitudes, which could result in underestimated photometric masses for directly-imaged exoplanets and young field brown dwarfs by 20 to 35%

TRAPPIST-1: Global results of the Spitzer Exploration Science Program Red Worlds

With more than 1000 hours of observation from Feb 2016 to Oct 2019, the Spitzer Exploration Program Red Worlds (ID: 13067, 13175 and 14223) exclusively targeted TRAPPIST-1, a nearby (12pc) ultracool dwarf star orbited by seven transiting Earth-sized planets, all well-suited for a detailed atmospheric characterization with the upcoming JWST. In this paper, we present the global results of the project. We analyzed 88 new transits and combined them with 100 previously analyzed transits, for a total of 188 transits observed at 3.6 or 4.5 $\mu$m. We also analyzed 29 occultations (secondary eclipses) of planet b and eight occultations of planet c observed at 4.5 $\mu$m to constrain the brightness temperatures of their daysides. We identify several orphan transit-like structures in our Spitzer photometry, but all of them are of low significance. We do not confirm any new transiting planets. We estimate for TRAPPIST-1 transit depth measurements mean noise floors of $\sim$35 and 25 ppm in channels 1 and 2 of Spitzer/IRAC, respectively. most of this noise floor is of instrumental origins and due to the large inter-pixel inhomogeneity of IRAC InSb arrays, and that the much better interpixel homogeneity of JWST instruments should result in noise floors as low as 10ppm, which is low enough to enable the atmospheric characterization of the planets by transit transmission spectroscopy. We construct updated broadband transmission spectra for all seven planets which show consistent transit depths between the two Spitzer channels. We identify and model five distinct high energy flares in the whole dataset, and discuss our results in the context of habitability. Finally, we fail to detect occultation signals of planets b and c at 4.5 $\mu$m, and can only set 3$\sigma$ upper limits on their dayside brightness temperatures (611K for b 586K for c)

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

π Earth: A 3.14 day Earth-sized Planet from K2's Kitchen Served Warm by the SPECULOOS Team

We report on the discovery of a transiting Earth-sized (0.95 R_⊕) planet around an M3.5 dwarf star at 57 pc, EPIC 249631677. The planet has a period of ~3.14 days, i.e., ~π, with an installation of 7.45 S_⊕. The detection was made using publicly available data from K2's Campaign 15. We observed three additional transits with SPECULOOS Southern and Northern Observatories, and a stellar spectrum from Keck/HIRES, which allowed us to validate the planetary nature of the signal. The confirmed planet is well suited for comparative terrestrial exoplanetology. While exoplanets transiting ultracool dwarfs present the best opportunity for atmospheric studies of terrestrial exoplanets with the James Webb Space Telescope, those orbiting mid-M dwarfs within 100 pc such as EPIC 249631677b will become increasingly accessible with the next generation of observatories