A Country Level Evaluation of the Impact of E-government: the Case of Italy

Despite considerable investments made worldwide in e-government initiatives in the past years, whether e-government succeeded in achieving the expected benefits in terms of increased efficiency, effectiveness and quality in the delivery of services is still under discussion. This chapter proposes an evaluation of the outcomes of the National Action Plan (NAP) for the diffusion of e-government at the local level in Italy. The evaluation considers whether the implementation of the projects funded under the action plan determined positive effects at the country level in terms of an increase in the value generated for different stakeholders. The discussion of data from both national and international secondary sources shows that during the period in which the benefits of the NAP should have become apparent no positive effects have emerged with evidence. The chapter argues that this depends on some of the principles the NAP has been based on that limited its capability of achieving the expected results

An Architecture Driven Methodology for Transforming from Fragmented to Connected Government: A Case of a Local Government in Italy

Connected government implies that citizens and enterprises can interact with government as with a single entity rather than with a number of different public authorities. In countries characterized by a highly fragmented system of Local Government, connected government at the local level can be achieved only through a process of progressive integration on a wider area of systems of local government already integrated at the local level. In the chapter, the author argues that this process should be based on a maturity model and a reference model that define the technological and organizational conditions that allow the establishment of more and more integrated aggregations of municipalities. With reference to a study funded by the Region Lombardia (Italy), the chapter introduces the concept of Integrated System of Local Government (ISLG) and describes the process that leads to the establishment of ISLGs as an intermediate step toward connected government at the local level. Moreover, the chapter discusses the conditions that can induce different aggregations of municipalities to comply with a set of standard requirements in the implementation of their integration processes

Regional disparities and industrial structure: territorial capital and productivity in Italian firms

We investigate the role of Territorial Capital (TC) on the productivity of Italian firms, constructing indicators for eight dimensions of TC in a first attempt to capture a wide variety of regional resources. When imposing homogeneous TC effects on all firms, we find that technological, social, institutional, financial and infrastructure capital drive productivity. However, only technological and artistic capital contribute to reduce regional disparities. Across industries, financial capital and infrastructure increase productivity in companies operating in a wide range of sectors. Industrial policies should consider sectoral heterogeneity and North-South differences to effectively boost productivity performance

ICT for Social Inclusion and Equal Opportunities: CETI-D, an e-Governance Good Practice in Brazil

In this chapter we discuss a Knowledge Economy based approach to the inclusion of persons with disabilities (PwD) that, different from the traditional \u201cassistance\u201d model, considers PwD as active and valuable members of the present Knowledge Society, to be included in the active workforce. This approach will be discussed with reference to a specific operational case study concerning the establishment of the Center of Excellence for Technology and Innovation in Favor of Persons with Disabilities (CETI-D) conceived by Fondazione Rosselli Americas and being implemented by the State of Sao Paulo in Brazil. In the first section of the chapter we discuss the problem of the inclusion of PwD as a further aspect of the digital divide phenomenon. In the second section the principles of the United Nation Convention on the Rights of Persons with Disabilities are presented and some international best practices concerning the social inclusion of PwD are introduced. In the third section we discuss the CETI-D initiative, with the aim of showing how ICT can represent a powerful tool for social and economic inclusion. Finally, in the fourth section we discuss the conditions under which the experience of the CETI-D can be replicated in other countries, with a specific focus on less developed countries

Coexistence of localization and transport in many-body two-dimensional Aubry-André models

Whether disordered and quasiperiodic many-body quantum systems host a long-lived localized phase in the thermodynamic limit has been the subject of intense recent debate. While in one dimension, substantial evidence for such a many-body localized (MBL) phase exists, the behavior in higher dimensions remains an open puzzle. In disordered systems, for instance, it has been argued that rare regions may lead to thermalization of the whole system through a mechanism dubbed avalanche instability. In quasiperiodic systems, however, rare regions are altogether absent and the fate of a putative many-body localized phase has hitherto remained largely unexplored. In this work, we investigate the localization properties of two many-body quasiperiodic models, which are two-dimensional generalizations of the Aubry-André model. By studying numerically the out-of-equilibrium dynamics of large systems, we find very long-lived localization on experimentally relevant time scales. Surprisingly, we also observe large-scale transport along deterministic lines of weak potential, which appear in the investigated quasiperiodic models. Our results demonstrate that quasiperiodic many-body systems have the remarkable and counter-intuitive capability of exhibiting coexisting localization and transport properties—a phenomenon reminiscent of the behavior of supersolids. Our findings are of direct experimental relevance and can be tested, for instance, using state-of-the-art cold atomic systems

Regulation of Schwann cells oncotransformation by changes in Nf2/merlin expression, Hippo/YAP signaling and DNA methylation

Schwann cell (SC) express the Neurofibromin type 2 gene (Nf2), encoding the tumor suppressor protein merlin, a cytoskeleton-associated protein regulating cell proliferation and survival. Nf2/merlin inactivation causes protein loss and leads to SC transformation into a form of benign tumor called schwannoma. Moreover, Nf2/merlin is mutated in an autosomal dominant multiple syndrome, called neurofibromatosis type 2. In line with observation that physio/mechanical cues, such as environmental challenges, may be pathogenetically relevant for SC oncotransformation, we recently showed that the exposure to electromagnetic fields (EMFs) causes changes in SC Nf2/merlin expression, cell migration, chemotactic responsivity and cytoskeleton reorganization. We showed a downstream MAPK/Erk activation, involved in SC proliferation, as well as activation of Hippo/YAP signalling commonly altered during tumorigenesis. We also showed that some genes, known to be upstream or downstream mediators of Hippo (Amotl2, Dchs, Fat, Wnt1) were changed. Further studies on rat SC oncotransformation following acute EMF exposure (0.1 T, 50 Hz, 10 min) demonstrated that the number of cells in G1 phase was increased. Focus forming analysis, after repeated exposures, showed an increase in 3D SC growth. EMF affects also the SC epigenome, as total DNA methylation, de novo DNMT and HDAC were reduced. Furthermore, RT2-profile assay evidenced that genes crucial for SCs are upregulated in EMF exposed cells. Overall, we identified some mechanisms responsible of environmental-induced SC changes toward a proliferative/migrating state, which may be pathologically relevant for nerve tumor development

Dynamic susceptibility of a spin ice near the critical point

We consider spin ice magnets (primarily, $\mathrm{Dy_2Ti_2O_7}$) in the vicinity of their critical point on the $(H,T)$ plane. We find that the longitudinal susceptibility diverges at the critical point, leading to the behaviour qualitatively similar to the one which would result from non-zero conductance of magnetic charges. We show that dynamics of critical fluctuations belongs to the universality class of easy-axis ferroelectric and calculate logarithmic corrections (within two-loop approximation) to the mean-field critical behavior.Comment: 5 pages, 3 figures. Some misprints are corrected, among them are the formula (20) and the estimation for $\Gamma_c

Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons

Protein kinase type C-\u3b5 (PKC\u3b5) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these neurons, PKC\u3b5 is modulated through the local release of mediators by the surrounding Schwann cells (SCs). The progesterone metabolite allopregnanolone (ALLO) is endogenously synthesized by SCs, whereas it has proven to be a crucial mediator of neuron-glia interaction in peripheral nerve fibers. Biomolecular and pharmacological studies on rat primary SCs and dorsal root ganglia (DRG) neuronal cultures were aimed at investigating the hypothesis that ALLO modulates neuronal PKC\u3b5, playing a role in peripheral nociception. We found that SCs tonically release ALLO, which, in turn, autocrinally upregulated the synthesis of the growth factor brain-derived neurotrophic factor (BDNF). Subsequently, glial BDNF paracrinally activates PKC\u3b5 via trkB in DRG sensory neurons. Herein, we report a novel mechanism of SCs-neuron cross-talk in the peripheral nervous system, highlighting a key role of ALLO and BDNF in nociceptor sensitization. These findings emphasize promising targets for inhibiting the development and chronification of neuropathic pain

Topological Entanglement Entropy of a Bose-Hubbard Spin Liquid

The Landau paradigm of classifying phases by broken symmetries was demonstrated to be incomplete when it was realized that different quantum Hall states could only be distinguished by more subtle, topological properties. Today, the role of topology as an underlying description of order has branched out to include topological band insulators, and certain featureless gapped Mott insulators with a topological degeneracy in the groundstate wavefunction. Despite intense focus, very few candidates for these topologically ordered "spin liquids" exist. The main difficulty in finding systems that harbour spin liquid states is the very fact that they violate the Landau paradigm, making conventional order parameters non-existent. Here, we uncover a spin liquid phase in a Bose-Hubbard model on the kagome lattice, and measure its topological order directly via the topological entanglement entropy. This is the first smoking-gun demonstration of a non-trivial spin liquid, identified through its entanglement entropy as a gapped groundstate with emergent Z2 gauge symmetry.Comment: 4+ pages, 3 figure

Structure factor of polymers interacting via a short range repulsive potential: application to hairy wormlike micelles

We use the Random Phase Approximation (RPA) to compute the structure factor, S(q), of a solution of chains interacting through a soft and short range repulsive potential V. Above a threshold polymer concentration, whose magnitude is essentially controlled by the range of the potential, S(q) exhibits a peak whose position depends on the concentration. We take advantage of the close analogy between polymers and wormlike micelles and apply our model, using a Gaussian function for V, to quantitatively analyze experimental small angle neutron scattering profiles of semi-dilute solutions of hairy wormlike micelles. These samples, which consist in surfactant self-assembled flexible cylinders decorated by amphiphilic copolymer, provide indeed an appropriate experimental model system to study the structure of sterically interacting polymer solutions