16 research outputs found
INDEPENDENT PREDICTORS OF METACHRONOUS BLADDER TRANSITIONAL CELL CARCINOMA AFTER NEPHROURETERECTOMY FOR TRANSITIONAL CELL CARCINOMA OF THE UPPER URINARY TRACT
INDEPENDENT PREDICTORS OF CONTRA LATERAL METACHRONOUS UPPER URINARY TRACT TRANSITIONAL CELL CARCINOMA AFTER NEPHROURETERECTOMY: MULTI- INSTITUTIONAL DATASET FROM 3 EUROPEAN CENTRES
Esophageal Cancer in Elderly Patients, Current Treatment Options and Outcomes; A Systematic Review and Pooled Analysis.
Esophageal cancer, despite its tendency to increase among younger patients, remains a disease of the elderly, with the peak incidence between 70-79 years. In spite of that, elderly patients are still excluded from major clinical trials and they are frequently offered suboptimal treatment even for curable stages of the disease. In this review, a clear survival benefit is demonstrated for elderly patients treated with neoadjuvant treatment, surgery, and even definitive chemoradiation compared to palliative or no treatment. Surgery in elderly patients is often associated with higher morbidity and mortality compared to younger patients and may put older frail patients at increased risk of autonomy loss. Definitive chemoradiation is the predominant modality offered to elderly patients, with very promising results especially for squamous cell cancer, although higher rates of acute toxicity might be encountered. Based on the all the above, and although the best available evidence comes from retrospective studies, it is not justified to refrain from curative treatment for elderly patients based on their age alone. Thorough assessment and an adapted treatment plan as well as inclusion of elderly patients in ongoing clinical trials will allow better understanding and management of esophageal cancer in this heterogeneous and often frail population
Independent predictors of cancer-specific survival in transitional cell carcinoma of the upper urinary tract - Multi-institutional dataset from 3 European centers
BACKGROUND: The objective of the current study was to identify variables that
were predictive of cancer-specific survival in patients with nonmetastatic
transitional cell carcinoma of the upper urinary tract (UUT-TCC).
METHODS: Clinical and pathologic data from 269 patients who underwent
nephroureterectomy for UUT-TCC from 1989 to 2005 in 3 urologic European centers
were collected retrospectively. Log-rank tests and Cox proportional-hazards
regression models were used for univariate and multivariate analyses.
RESULTS: Two hundred fifty patients underwent nephroureterectomy, and 19 patients
underwent concomitant cystectomy for synchronous muscle-invasive bladder cancer.
The median follow-up of the whole cohort was 34 months, and the median follow-up
of the patients who remained alive and disease-free was 52 months. At follow-up,
57 cancer-related deaths (21.2%) were censored, and 169 patients (62.8%) were
alive and disease-free. On univariate analysis, a history of previous bladder
cancer, pathologic stage of the primary tumor and lymph nodes, tumor grade, the
presence of lymphovascular invasion, tumor site, synchronous muscle-invasive
bladder TCC, and tumor multifocality were associated with cancer-specific
survival probabilities. On multivariate analysis, pathologic stage of the primary
tumor and lymph nodes, tumor multifocality within the UUT, synchronous
muscle-invasive bladder TCC, and a history of bladder TCC before the diagnosis of
UUT-TCC were independent predictors of cancer-specific survival probabilities.
CONCLUSIONS: In a multi-institutional dataset of patients who had undergone
nephroureterectomy for UUT-TCC, the current results indicated that pathologic
stage of the primary tumor and lymph nodes, a history of prior bladder TCC, the
presence of synchronous muscle-invasive bladder cancer, and tumor multifocality
within the UUT were independent predictors of cancer-specific survival
probabilities
Independent predictors of metachronous bladder transitional cell carcinoma (TCC) after nephroureterectomy for TCC of the upper urinary tract.
OBJECTIVE: To identify the prognostic factors predictive of metachronous bladder
transitional cell carcinoma (TCC) in a multi-institutional dataset of patients
who had undergone nephroureterectomy (NU) for nonmetastatic upper urinary tract
(UUT) TCC.
PATIENTS AND METHODS: The clinical and pathological data of 231 patients who had
had NU for UUT-TCC from 1989 to 2005 in three European centres were collected
retrospectively, and analysed for clinical and pathological variables.
RESULTS: The median follow-up was 38 months; during the follow-up, bladder TCC
was detected in 109 patients (47.2%), and was significantly more common in
patients who had UUT-TCC after previous bladder TCC (P < 0.001), in those with
ureteric cancer (P = 0.022), and in those with pT2 UUT-TCC (P = 0.017). On
multivariate analysis, a previous history of bladder TCC was the only independent
predictor of metachronous bladder TCC (hazard ratio 2.825; P < 0.001). The 5-year
probability of being free from metachronous bladder TCC was 45.5%. A history of
bladder TCC (P < 0.001) and UUT tumour site (P = 0.01) were significantly
associated with the probability of bladder recurrence-free survival. On
multivariate analyses, a previous history of bladder TCC (hazard ratio 2.226; P <
0.001) and the presence of ureteric TCC (1.562; P = 0.036) were independent
predictors of the probabilities of being free from metachronous bladder TCC.
CONCLUSION: In this multi-institutional study of patients who had had NU for
UUT-TCC, a history of bladder TCC was the only independent predictor of
metachronous bladder TCC, while both a history of bladder TCC and the presence of
ureteric tumours were predictive of the probabilities of being free from
metachronous bladder TC
Status of the ESS elliptical cryomodules at CEA saclay
The first ESS prototype cryomodule with medium beta cavities named M-ECCTD is being assembled at CEA Saclay. The Q curves of the 4 cavities mounted inside the cryomodule are presented, and the four power couplers have been conditioned at high power before their assembly onto the cavity string. Completion of the M-ECCTD assembly outside clean room is in progress as well as the finalization of the RF power test stand preparation. RF power tests of the M-ECCTD will be performed during summer 2017. CEA is preparing the production of the ESS medium and high beta cryomodules of the series before the test of the M-ECCTD and the contracts for the procurement of the most critical components have already been signed
Status of the ESS Elliptical Cryomodules at CEA Saclay
International audienceThe first ESS prototype cryomodule with medium beta cavities named M-ECCTD is being assembled at CEA Saclay. The Q curves of the 4 cavities mounted inside the cryomodule are presented, and the four power couplers have been conditioned at high power before their assembly onto the cavity string. Completion of the M-ECCTD assembly outside clean room is in progress as well as the finalization of the RF power test stand preparation. RF power tests of the M-ECCTD will be performed during summer 2017. CEA is preparing the production of the ESS medium and high beta cryomodules of the series before the test of the M-ECCTD and the contracts for the procurement of the most critical components have already been signe