Restoration Of Dual-Frequency Signals With Nonlinear Propagation In Fibers With Positive Group-Velocity Dispersion

It is shown experimentally and theoretically that a sinusoidally modulated pulse evolves with time into a train of dark soliton-like pulses and then returns to its initial sinusoidal shape on propagation through a nonlinear single-mode fiber with positive group velocity dispersion. The experimental results are in agreement with predictions from the nonlinear Schrodinger equation

Octet, decuplet and antidecuplet magnetic moments in the chiral quark soliton model revisited

We reanalyse the magnetic moments of the baryon octet, decuplet, and antidecuplet within the framework of the chiral quark-soliton model, with SU(3) symmetry breaking taken into account. We consider the contributions of the mixing of higher representations to the magnetic moment operator arising from the SU(3) symmetry breaking. Dynamical parameters of the model are fixed by experimental data for the magnetic moments of the baryon octet and from the masses of the octet, decuplet and of $\Theta^{+}$. The magnetic moment of $\Theta^{+}$ depends rather strongly on the pion-nucleon sigma term and reads $-1.19 {\rm n.m.}$ to $-0.33 {\rm n.m.}$ for $\Sigma_{\pi N} = 45$ and 75 MeV respectively. The recently reported mass of $\Xi^{--}_{\bar{10}}(1862)$ is compatible with $\Sigma_{\pi N} = 73$ MeV. As a byproduct the strange magnetic moment of the nucleon is obtained with a value of $\mu^{(s)}_N =+0.39$ n.m.Comment: RevTeX is used. 12 pages, 3 figures, final version for publication in Phys. Rev.

Magnetic Moments of Decuplet Baryons in Light Cone QCD

We calculate the magnetic moments of decuplet baryons containing strange quarks within the framework of light cone QCD sum rules taking into account the SU(3) flavor symmetry breaking effects. It is obtained that magnetic moments of the neutral \sso and \xis0 baryons are mainly determined by the SU(3) breaking terms. A comparison of our results on the magnetic moments of the decuplet baryons with the predictions of other approaches is presented.Comment: Latex, 20 pages, 6 figure

A new diagnostic algorithm for Burkitt and diffuse large B-cell lymphomas based on the expression of CSE1L and STAT3 and on MYC rearrangement predicts outcome

Background Aggressive mature B-cell non-Hodgkin's lymphomas (BCL) sharing features of Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) (intermediate BL/DLBCL) but deviating with respect to one or more characteristics are increasingly recognized. The limited knowledge about these biologically heterogeneous lymphomas hampers their assignment to a known entity, raising incertitude about optimal treatment approaches. We therefore searched for discriminative, prognostic, and predictive factors for their better characterization. Patients and methods We analyzed 242 cytogenetically defined aggressive mature BCL for differential protein expression. Marker selection was based on recent gene-expression profile studies. Predictive models for diagnosis were established and validated by a different set of lymphomas. Results CSE1L- and inhibitor of DNA binding-3 (ID3)-overexpression was associated with the diagnosis of BL and signal transduction and transcription-3 (STAT3) with DLBCL (P<0.001 for all markers). All three markers were associated with patient outcome in DLBCL. A new algorithm discriminating BL from DLBCL emerged, including the expression of CSE1L, STAT3, and MYC translocation. This ‘new classifier' enabled the identification of patients with intermediate BL/DLBCL who benefited from intensive chemotherapy regimens. Conclusion The proposed algorithm, which is based on markers with reliable staining properties for routine diagnostics, represents a novel valid tool in separating BL from DLBCL. Most interestingly, it allows segregating intermediate BL/DLBCL into groups with different treatment requirement

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering.

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non-homologous end-joining (NHEJ) or homologous recombination (HR) DNA repair pathways. However, a direct involvement of these pathways has remained unclear. Here, we show that the silencing of many HR factors enhanced plasmid concatemer formation and stable expression of the gene of interest in Chinese hamster ovary (CHO) cells, while the inhibition of NHEJ had no effect. However, genomic integration was decreased by the silencing of specific HR components, such as Rad51, and DNA synthesis-dependent microhomology-mediated end-joining (SD-MMEJ) activities. Genome-wide analysis of the integration loci and junction sequences validated the prevalent use of the SD-MMEJ pathway for transgene integration close to cellular genes, an effect shared with matrix attachment region (MAR) DNA elements that stimulate plasmid integration and expression. Overall, we conclude that SD-MMEJ is the main mechanism driving the illegitimate genomic integration of foreign DNA in CHO cells, and we provide a recombination engineering approach that increases transgene integration and recombinant protein expression in these cells. Biotechnol. Bioeng. 2017;114: 384-396. © 2016 The Authors. Biotechnology and Bioengineering published by Wiley Periodicals, Inc

The reaction γp→π∘γ′p\gamma p \to \pi^\circ \gamma^\prime p and the magnetic dipole moment of the Δ+(1232)\Delta^+(1232) resonance

The reaction $\gamma p \to \pi^\circ \gamma^\prime p$ has been measured with the TAPS calorimeter at the Mainz Microtron accelerator facility MAMI for energies between $\sqrt{s}$ = 1221--1331 MeV. Cross sections differential in angle and energy have been determined for all particles in the final state in three bins of the excitation energy. This reaction channel provides access to the magnetic dipole moment of the $\Delta^{+}(1232)$ resonance and, for the first time, a value of $\mu_{\Delta^+} = (2.7_{-1.3}^{+1.0}(stat.) \pm 1.5 (syst.) \pm 3(theo.)) \mu_N$ has been extracted

Magnetic moments of the SU(3) decuplet baryons in the chiral quark-soliton model

Magnetic moments of baryons are studied within the chiral quark soliton model with special emphasis on the decuplet of baryons. The model is used to identify all symmetry breaking terms proportional to $m_{\rm s}$. Sum rules for the magnetic moments are derived. A ``model-independent'' analysis of the symmetry breaking terms is performed and finally model calculations are presented, which show the importance of the rotational $1/N_{\rm c}$ corrections for cranking of the soliton.Comment: 22 pages, RevTex. The final version accepted for publication in Phys. Rev.

The Decuplet Revisited in χ\chiPT

The paper deals with two issues. First, we explore the quantitiative importance of higher multiplets for properties of the $\Delta$ decuplet in chiral perturbation theory. In particular, it is found that the lowest order one--loop contributions from the Roper octet to the decuplet masses and magnetic moments are substantial. The relevance of these results to the chiral expansion in general is discussed. The exact values of the magnetic moments depend upon delicate cancellations involving ill--determined coupling constants. Second, we present new relations between the magnetic moments of the $\Delta$ decuplet that are independent of all couplings. They are exact at the order of the chiral expansion used in this paper.Comment: 7 pages of double column revtex, no figure

Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients

Background: Exclusive liver metastases occur in up to 40% of patients with uveal melanoma associated with a median survival of 2-7 months. Single agent response rates with commonly available chemotherapy are below 10%. We have investigated the use of fotemustine via direct intra-arterial hepatic (i.a.h.) administration in patients with uveal melanoma metastases. Patients and methods: A total of 101 patients from seven centers were treated with i.a.h. fotemustine, administered intra-arterially weekly for a 4-week induction period, and then as a maintenance treatment every 3 weeks until disease progression, unacceptable toxicity or patient refusal. Results: A median of eight fotemustine infusions per patient were delivered (range 1-26). Catheter related complications occurred in 23% of patients; however, this required treatment discontinuation in only 10% of the patients. The overall response rate was 36% with a median overall survival of 15 months and a 2-year survival rate of 29%. LDH, time between diagnosis and treatment start and gender were significant predictors of survival. Conclusions: Locoregional treatment with fotemustine is well tolerated and seems to improve outcome of this poor prognosis patient population. Median survival rates are among the longest reported and one-third of the patients are still alive at 2 year