793 research outputs found
Expression of Sox1, Sox2 and Sox9 is maintained in adult human cerebellar cortex
Neural stem cells (NSCs) have been found to reside in defined areas of the vertebrate brain, where they can be identified by the expression of specific markers such as Sox1, Sox2 and Sox9. In the mouse, expression of Sox1, Sox2 and Sox9 genes has recently been reported outside of these recognised NSC niches, in the Purkinje cell layer of the adult cerebellum. The present study establishes that expression of these marker genes is also found in the human cerebellum beyond the maturation phase. Expression of Sox1, Sox2 and Sox9 was detected at the mRNA level in both foetal and adult cerebellum samples, suggesting that the maintenance of these markers in adult tissue is also observed in the human cerebellum. Expression of these markers was further confirmed at the protein level on human tissue sections, as Sox1, Sox2 and Sox9 expression was detected in the Purkinje cell layer of the adult cerebellum. The present study demonstrates that Sox1 and Sox2 are expressed in the human adult cerebellum, outside of the characterised NSC niches. © 2008 Elsevier Ireland Ltd. All rights reserved
On the Correlated X-ray and Optical Evolution of SS Cygni
We have analyzed the variability and spectral evolution of the prototype
dwarf nova system SS Cygni using RXTE data and AAVSO observations. A series of
pointed RXTE/PCA observations allow us to trace the evolution of the X-ray
spectrum of SS Cygni in unprecedented detail, while 6 years of optical AAVSO
and RXTE/ASM light curves show long-term patterns. Employing a technique in
which we stack the X-ray flux over multiple outbursts, phased according to the
optical light curve, we investigate the outburst morphology. We find that the
3-12 keV X-ray flux is suppressed during optical outbursts, a behavior seen
previously, but only in a handful of cycles. The several outbursts of SS Cygni
observed with the more sensitive RXTE/PCA also show a depression of the X-rays
during optical outburst. We quantify the time lags between the optical and
X-ray outbursts, and the timescales of the X-ray recovery from outburst. The
optical light curve of SS Cygni exhibits brief anomalous outbursts. During
these events the hard X-rays and optical flux increase together. The long-term
data suggest that the X-rays decline between outburst. Our results are in
general agreement with modified disk instability models (DIM), which invoke a
two-component accretion flow consisting of a cool optically thick accretion
disk truncated at an inner radius, and a quasi-spherical hot corona-like flow
extending to the surface of the white dwarf. We discuss our results in the
framework of one such model, involving the evaporation of the inner part of the
optically thick accretion disk, proposed by Meyer & Meyer-Hofmeister (1994).Comment: 24 pages, 8 figures, 2 tables, accepted for publication in Ap
The fluorine link between a supergiant ore deposit and a silicic large igneous province
Olympic Dam is a supergiant Fe oxide Cu-U-Au-Ag ore deposit (~9 Ă 109 t) that is also enriched in rare earth elements (REEs) and fluorine (F). The immediate host to the ore is hydrothermal breccia within granite and volcanic rocks of a Mesoproterozoic silicic large igneous province. Analyses of melt inclusions in quartz phenocrysts in rhyolite show that the silicic magmas of this province were unusually rich in F (up to 1.3 wt%). Fluorite and other F-rich minerals that crystallized from these magmas provided a gigantic reservoir of F. As a result, the Olympic Dam ore-forming fluid was F-rich and had exceptional capacity to transport diverse elements. Further, we infer that hydrofluoric acid, the most corrosive acid known, contributed to hydrothermal breccia formation by dissolution that in turn increased permeability and accelerated the rate of fluid-rock interaction. It is no accident that the world's largest hydrothermal ore deposit occurs in an F-rich silicic large igneous province
Phase transitions in the Potts spin glass model
We have studied the Potts spin glass with 2-state Ising spins and s-state
Potts variables using a cluster Monte Carlo dynamics. The model recovers the +-
J Ising spin glass (SG) for s=1 and exhibits for all s a SG transition at
T_{SG}(s) and a percolation transition at higher temperature T_p(s). We have
shown that for all values of at T_p(s) there is a thermodynamical
transition in the universality class of a ferromagnetic s-state Potts model.
The efficiency of the cluster dynamics is compared with that of standard spin
flip dynamics.Comment: 8 pages, Latex, with 8 EPS fig
General-relativistic constraints on the equation of state of dense matter implied by kilohertz quasi-periodic oscillations in neutron-star X-ray binaries
If the observed millisecond variability in the X-ray flux of several
neutron-star low-mass X-ray binaries (LMXBs) is interpreted within a
general-relativistic framework (Kluzniak, Michelson \& Wagoner 1990) extant at
the time of discovery, severe constraints can be placed on the equation of
state (e.o.s.) of matter at supranuclear densities. The reported maximum
frequency (1.14 +- 0.01 kHz) of quasiperiodic oscillations observed in sources
as diverse as Sco X-1 and 4U 1728-34 would imply that the neutron star masses
in these LMXBs are M > 1.9 M_solar, and hence many equations of state would be
excluded. Among the very few still viable equations of state are the e.o.s. of
Phandaripande and Smith (1975), and e.o.s. AV14 + UVII of Wiringa, Fiks \&
Fabrocini (1988).Comment: The figures can be found in the references cited in the captions. A
longer version of this paper was submitted to a refereed journal on January
6, 1997 (345 days ago
Scanning electrochemical microscopy as a local probe of oxygen permeability in cartilage
The use of scanning electrochemical microscopy, a high-resolution chemical imaging technique, to probe the distribution and mobility of solutes in articular cartilage is described. In this application, a mobile ultramicroelectrode is positioned close (not, vert, similar1 ÎŒm) to the cartilage sample surface, which has been equilibrated in a bathing solution containing the solute of interest. The solute is electrolyzed at a diffusion-limited rate, and the current response measured as the ultramicroelectrode is scanned across the sample surface. The topography of the samples was determined using Ru(CN)64â, a solute to which the cartilage matrix was impermeable. This revealed a number of pit-like depressions corresponding to the distribution of chondrocytes, which were also observed by atomic force and light microscopy. Subsequent imaging of the same area of the cartilage sample for the diffusion-limited reduction of oxygen indicated enhanced, but heterogeneous, permeability of oxygen across the cartilage surface. In particular, areas of high permeability were observed in the cellular and pericellular regions. This is the first time that inhomogeneities in the permeability of cartilage toward simple solutes, such as oxygen, have been observed on a micrometer scale
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
Background
Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared
the efficacy and safety of two antiplatelet regimens â aspirin plus extendedrelease
dipyridamole (ASAâERDP) versus clopidogrel.
Methods
In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive
25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily or to receive
75 mg of clopidogrel daily. The primary outcome was first recurrence of stroke.
The secondary outcome was a composite of stroke, myocardial infarction, or death
from vascular causes. Sequential statistical testing of noninferiority (margin of 1.075),
followed by superiority testing, was planned.
Results
A total of 20,332 patients were followed for a mean of 2.5 years. Recurrent stroke
occurred in 916 patients (9.0%) receiving ASAâERDP and in 898 patients (8.8%) receiving
clopidogrel (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11). The
secondary outcome occurred in 1333 patients (13.1%) in each group (hazard ratio for
ASAâERDP, 0.99; 95% CI, 0.92 to 1.07). There were more major hemorrhagic events
among ASAâERDP recipients (419 [4.1%]) than among clopidogrel recipients (365
[3.6%]) (hazard ratio, 1.15; 95% CI, 1.00 to 1.32), including intracranial hemorrhage
(hazard ratio, 1.42; 95% CI, 1.11 to 1.83). The net risk of recurrent stroke or major
hemorrhagic event was similar in the two groups (1194 ASAâERDP recipients [11.7%],
vs. 1156 clopidogrel recipients [11.4%]; hazard ratio, 1.03; 95% CI, 0.95 to 1.11).
Conclusions
The trial did not meet the predefined criteria for noninferiority but showed similar rates
of recurrent stroke with ASAâERDP and with clopidogrel. There is no evidence that either
of the two treatments was superior to the other in the prevention of recurrent
stroke. (ClinicalTrials.gov number, NCT00153062.
Evidences for a quasi 60-year North Atlantic Oscillation since 1700 and its meaning for global climate change
The North Atlantic Oscillation (NAO) obtained using instrumental and
documentary proxy predictors from Eurasia is found to be characterized by a
quasi 60-year dominant oscillation since 1650. This pattern emerges clearly
once the NAO record is time integrated to stress its comparison with the
temperature record. The integrated NAO (INAO) is found to well correlate with
the length of the day (since 1650) and the global surface sea temperature
record HadSST2 and HadSST3 (since 1850). These findings suggest that INAO can
be used as a good proxy for global climate change, and that a 60-year cycle
exists in the global climate since at least 1700. Finally, the INAO ~60-year
oscillation well correlates with the ~60- year oscillations found in the
historical European aurora record since 1700, which suggests that this 60-year
dominant climatic cycle has a solar-astronomical origin
Reprint: Good laboratory practice: preventing introduction of bias at the bench
As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke
Infrared spectroscopy of Nova Cassiopeiae 1993 (V705 Cas). IV. A closer look at the dust
Nova Cassiopeiae 1993 (V705 Cas) was an archetypical dust-forming nova. It
displayed a deep minimum in the visual light curve, and spectroscopic evidence
for carbon, hydrocarbon and silicate dust. We report the results of fitting the
infrared spectral energy distribution with the DUSTY code, which we use to
determine the properties and geometry of the emitting dust. The emission is
well described as originating in a thin shell whose dust has a carbon:silicate
ratio of ~2:1 by number (1.26:1 by mass) and a relatively flat size
distribution. The 9.7micron and 18micron silicate features are consistent with
freshly-condensed dust and, while the lower limit to the grain size
distribution is not well constrained, the largest grains have dimensions
\~0.06micron; unless the grains in V705 Cas were anomalously small, the sizes
of grains produced in nova eruptions may previously have been overestimated in
novae with optically thick dust shells. Laboratory work by Grishko & Duley may
provide clues to the apparently unique nature of nova UIR features.Comment: 11 pages, 9 fugure
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