Multi-dimensional laser spectroscopy of exciton-polaritons with spatial light modulators

We describe an experimental system that allows one to easily access the dispersion curve of exciton-polaritons in a microcavity. Our approach is based on two spatial light modulators (SLM), one for changing the excitation angles (momenta), and the other for tuning the excitation wavelength. We show that with this setup, an arbitrary number of states can be excited accurately and that re-configuration of the excitation scheme can be done at high speed.Comment: 4 pages, 5 figure

Polyethylene imine-based receptor immobilization for label free bioassays

Polyethylene imine (PEI) based immobilization of antibodies is described and the concept is proved on the label free assay of C-Reactive Protein (CRP). This novel immobilization method is composed of a hyperbranched PEI layer which was deposited at a high pH (9.5) on the sensor surface. The free amino groups of PEI were derivatized with neutravidin by Biotin N-hydroxysuccinimide ester and the biotinylated anti-CRP antibody immobilized on this layer. Direct binding assay of recombinant CRP was successfully performed in the low μg/ml concentrations using a label free optical waveguide biosensor

Multi-scale magnetic field intermittence in the plasma sheet

This paper demonstrates that intermittent magnetic field fluctuations in the plasma sheet exhibit transitory, localized, and multi-scale features. We propose a multifractal based algorithm, which quantifies intermittence on the basis of the statistical distribution of the 'strength of burstiness', estimated within a sliding window. Interesting multi-scale phenomena observed by the Cluster spacecraft include large scale motion of the current sheet and bursty bulk flow associated turbulence, interpreted as a cross-scale coupling (CSC) process.Comment: 18 pages, 7 figure

Scaling and a Fokker-Planck model for fluctuations in geomagnetic indices and comparison with solar wind as seen by Wind and ACE

The evolution of magnetospheric indices on temporal scales shorter than that of substorms is characterized by bursty, intermittent events that may arise from turbulence intrinsic to the magnetosphere or that may reflect solar wind-magnetosphere coupling. This leads to a generic problem of distinguishing between the features of the system and those of the driver. We quantify scaling properties of short-term (up to few hours) fluctuations in the geomagnetic indices AL and AU during solar minimum and maximum, along with the parameter that is a measure of the solar wind driver. We find that self-similar statistics provide a good approximation for the observed scaling properties of fluctuations in the geomagnetic indices, regardless of the solar activity level, and in the parameter at solar maximum. This self-similarity persists for fluctuations on timescales at least up to about 1–2 hours. The scaling exponent of AU index fluctuations show dependence on the solar cycle, and the trend follows that found in the scaling of fluctuations in . The values of their corresponding scaling exponents, however, are always distinct. Fluctuations in the AL index are insensitive to the solar cycle, as well as being distinct from those in the parameter. This approximate self-similar scaling leads to a Fokker-Planck model which, we show, captures the probability density function of fluctuations and provides a stochastic dynamical equation (Langevin equation) for time series of the geomagnetic indices

Towards bedside washing of stored red blood cells: a prototype of a simple apparatus based on microscale sedimentation in normal gravity

Background and ObjectivesInfusion of by?products of red blood cell (RBC) storage?induced degradation as well as of the residual plasma proteins and the anticoagulant?preservative solution contained in units of stored blood serve no therapeutic purpose and may be harmful to some patients. Here, we describe a prototype of a gravity?driven system for bedside washing of stored RBCs. Materials and Methods Stored RBCs were diluted to 10% haematocrit (Hct) with normal saline, matching the conventional washing procedure. The dilute RBC suspensions were passed through a column of coiled tubing to allow RBC sedimentation in normal gravity, thus separating them from the washing solution. Washed RBCs were collected using bifurcations located along the tubing. Washing efficiency was quantified by measuring Hct, morphology, deformability, free haemoglobin and total?free protein. Results The gravity?driven washing system operating at 0·5 ml/min produced washed RBCs with final Hct of 36·7 ± 3·4% (32·3–41·2%, n = 10) and waste Hct of 3·4 ± 0·7% (2·4–4·3%, n = 10), while removing 80% of free haemoglobin and 90% of total?free protein. Washing improved the ability of stored RBCs to perfuse an artificial microvascular network by 20%. The efficiency of washing performed using the gravity?driven system was not significantly different than that of conventional centrifugation. Conclusions This proof?of?concept study demonstrates the feasibility of washing stored RBCs using a simple, disposable system with efficiency comparable to that of conventional centrifugation, and thus represents a significant first step towards enabling low?cost washing of stored blood at bedside

Nyúltvelői neurovascularis kompresszió. A szekunder hypertonia ritka oka.

Compression of the rostral ventrolateral medulla oblongata is one of the rarely identified causes of refractory hypertension. In patients with severe, intractable hypertension caused by neurovascular compression, neurosurgical decompression should be considered. The authors present the history of a 20-year-old man with severe hypertension. After excluding other possible causes of secondary hypertension, the underlying cause of his high blood pressure was identified by the demonstration of neurovascular compression shown by magnetic resonance angiography and an increased sympathetic activity (sinus tachycardia) during the high blood pressure episodes. Due to frequent episodes of hypertensive crises, surgical decompression was recommended, which was performed with the placement of an isograft between the brainstem and the left vertebral artery. In the first six months after the operation, the patient's blood pressure could be kept in the normal range with significantly reduced doses of antihypertensive medication. Repeat magnetic resonance angiography confirmed the cessation of brainstem compression. After six months periodically increased blood pressure returned, but in smaller extent and less frequent. Based on the result of magnetic resonance angiography performed 22 months after surgery, re-operation was considerd. According to previous literature data long-term success can only be achieved in one third of patients after surgical decompression. In the majority of patients surgery results in a significant decrease of blood pressure, an increased efficiency of antihypertensive therapy as well as a decrease in the frequency of highly increased blood pressure episodes. Thus, a significant improvement of the patient's quality of life can be achieved. The case of this patient is an example of the latter scenario. Orv. Hetil., 2014, 155(21), 838-842