Анализ функционирования свободных экономических зон в России (на примере ОЭЗ «Янтарь» в Калининградской области

Целью работы является анализ функционирования особых экономических зон в России, на примере особой экономической зоны «Янтарь» в Калининградской области. В процессе исследования были изучены теоретические основы свободных экономических зон, так же проводился анализ состояния развития и перспектив свободных экономических зон в России, анализ состояния и эффективности особой экономической зоны «Янтарь» в Калининградской области. Кроме того, проводилось исследование деятельности таможенных органов на территории вышеупомянутой особой экономической зоны. В результате исследования были выявлены проблемы, которые препятствуют эффективной деятельности особой экономической зоны «Янтарь» и деятельности таможенных органов на ее территории.The aim is to analyze the functioning of special economic zones in Russia, in particular by the example of a special economic zone "Amber" in the Kaliningrad region. During the study in the course of research theoretical bases of free economic zones have been studied, also the analysis of a condition of development and prospects of free economic zones in Russia, the analysis of a condition and efficiency of the special economic zone "Amber" in the Kaliningrad region was carried out. In additional, research of activities of customs authorities in the territory of an above-mentioned special economic zone was conducted

Проект модернизации оборотного водоснабжения ТЭЦ ООО "Юргинский машзавод"

ТЭЦ являются одним из основных загрязнителей атмосферы твёрдыми частицами золы, окислами серы азота, другими веществами, оказывая вредное воздействие на здоровье людей, а также углекислым газом, способствующим возникновению «парникового эффекта». Поэтому предлагается сократить вредные выбросы путем оптимизации водно-химического режима ТЭЦ. Thermoelectric plant is one of the major polluters of the atmosphere solid particles of ash, nitrogen oxides, sulfur, and other substances, exerting harmful effects on human health, as well as carbon dioxide, contributing to the emergence of the "greenhouse effect." It is therefore proposed to reduce emissions through the optimization of water chemistry thermoelectric plant

¿Drug Trafficking as An Economic Source of The Country?

Las drogas son un problema para el país desde los años 3000 a.c, que son utilizadas normalmente como un relajante para salir y olvidarse del estrés o algunos casos simplemente por moda. En la mayoría de los casos las drogas se vuelven adicciones que al tiempo daña tu salud tanto física, emocional y mental. Las drogas son una fuga de dinero que no es compensada de ninguna manera, ya que la lucha contra las drogas no ha servido de nada a lo largo del tiempo, aunque existan muchas campañas de ayuda para las personas que son adictas o que apenas empiezan con esta mentalidad, no el 100% de los adictos son ayudados por que ellos no se consideran ser “adictos” ya que su mente no está en condiciones de aceptar lo que les está pasando.Drugs have been a problem for the country since 3000 BC, which are normally used as a relaxant to go out and forget about stress or in some cases simply for fashion. In most cases, drugs become addictions that at the same time damage your physical, emotional and mental health. Drugs are a drain of money that is not compensated in any way, since the fights against drugs have been of no use over time, since although there are many help campaigns for people who are addicted or who are just starting with this mentality, not 100% of addicts are helped because they do not consider themselves "addicted" since their mind is not in a position to accept what is happening to them

Crystallographic analysis of rock grain orientation at meso- and microscale levels

This paper studies the results of electron backscatter diffraction analysis of naturally deformedpolycrystalline olivine. It also defines the dependence of lattice-preferred orientations of grains on their microstructural position and size. The authors detect the basic mechanisms, consequence and thermal dynamic modes of deformation. They also show that the development of a polycrystalline structure is determined by the following consecutive activation of sliding systems (010)[100] → {0kl}[100] → (100)[010] → {100}[001] → {110}[001], when dislocation sliding and diffusion creep change under the temperature decrease from 1000°C to 650°C

Relative Configuration of Micrograms of Natural Compounds Using Proton Residual Chemical Shift Anisotropy

[Abstract] 3D molecular structure determination is a challenge for organic compounds or natural products available in minute amounts. Proton/proton and proton/carbon correlations yield the constitution. J couplings and NOEs oftentimes supported by one-bond 1H,13C residual dipolar couplings (RDCs) or by 13C residual chemical shift anisotropies (RCSAs) provide the relative configuration. However, these RDCs or carbon RCSAs rely on 1% natural abundance of 13C preventing their use for compounds available only in quantities of a few 10’s of µgs. By contrast, 1H RCSAs provide similar information on spatial orientation of structural moieties within a molecule, while using the abundant 1H spin. Herein, 1H RCSAs are accurately measured using constrained aligning gels or liquid crystals and applied to the 3D structural determination of molecules with varying complexities. Even more, deuterated alignment media allow the elucidation of the relative configuration of around 35 µg of a briarane compound isolated from Briareum asbestinum.This work was supported by the Max Planck Society and grew out of a collaboration in the context of the Forschergruppe (FOR 934) continued now by the DFG (Gr1211/19–1 and Re1007/9–1)/CAPES 418729698 project. N.N. gratefully acknowledges the financial support by SERB, New Delhi for ECR Grant with File No.: ECR/2017/001811. This work was also funded by grants RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, both co-funded by the FEDER Programme from the European Union, BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP) and GRC2018/039 and Agrupación Estratégica CICA-INIBIC ED431E 2018/03 from Xunta de Galicia. C.J., J.R., and D.P.P. acknowledge CESGA for the computational support. J.C.F. acknowledges predoctoral research stay grant Inditex-UDC. D.P.P. received a fellowship from the program National Council of Science and Technology (CONACYT) of Mexico and the Secretariat of Research, Innovation and Higher Education (SIIES) of Yucatan (Mexico). We also thank Dr. G. Jithender Reddy for one isotropic measurement. We also thank Dr. Christian Schmidt for his cooperation in the manufacturing of micro stretching device. ANV thanks CNPq for a research fellowship and financial support M(426216/2018–0)German Research Foundation; Gr1211/19–1German Research Foundation; Re1007/9–1Brasil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); 418729698República de la India. Science and Engineering Research Board; ECR/2017/001811Xunta de Galicia; 0474_BLUEBIOLAB_1_EXunta de Galicia; GRC2018/039Xunta de Galicia; ED431E 2018/03Brasil. Conselho Nacional de Desenvolvimento Científico e Tecnológico; M(426216/2018–0

In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa

[Abstract] The pyrrole-imidazoles, a group of alkaloids commonly found in marine sponges belonging to the genus Agelas, display a wide range of biological activities. Herein, we report the first chemical study of the secondary metabolites of the sponge A. dilatata from the coastal area of the Yucatan Peninsula (Mexico). In this study, we isolated eight known alkaloids from an organic extract of the sponge. We used NMR and MS analysis and comparison with existing databases to characterize the alkaloids: ageliferin (1), bromoageliferin (2), dibromoageliferin (3), sceptrin (4), nakamuric acid (5), 4-bromo-1H-pyrrole-2-carboxylic acid (6), 4,5-dibromopyrrole-2-carboxylic acid (7) and 3,7-dimethylisoguanine (8). We also evaluated, for the first time, the activity of these alkaloids against the most problematic multidrug-resistant (MDR) pathogens, i.e., the Gram-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Bromoageliferin (2) displayed significant activity against P. aeruginosa. Comparison of the antibacterial activity of ageliferins 1–3 (of similar structure) against P. aeruginosa revealed some relationship between structure and activity. Furthermore, in in vitro assays, 2 inhibited growth and biofilm production in clinical strains of P. aeruginosa. Moreover, 2 increased the survival time in an in vivo Galleria mellonella model of infection. The findings confirm bromoageliferin (2) as a potential lead for designing new antibacterial drugs.This work was supported by Grants RTI2018-093634-B-C22 (AEI/FEDER, EU) from the State Agency for Research (AEI) of Spain, both co-funded by the FEDER Programme from the European Union and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). The study was also funded by projects GRC2018/039 and Agrupación Estratégica CICA-INIBIC ED431E 2018/03 (Consellería de Educación, Universidades e Formación Profesional) from the Xunta de Galicia (autonomous government of the region). This work was also funded by Projects PI17/01482 awarded to AB and PI15/00860 to GB, all within in the National Plan for Scientific Research, Development and Technological Innovation 2013-2016 and funded by the ISCIII-General Subdirection of Assessment and Promotion of the Research-European Regional Development Fund (FEDER) “A way of making Europe” and operative program Intelligent Growth 2014-2020. The study was also funded by project IN607A 2016/22 (GAIN- Agencia Gallega de Innovación - Consellería de Economía, Emprego e Industria) awarded to GB. D.P.-P. received a fellowship from the program National Council of Science and Technology (CONACYT) of Mexico and the Secretariat of Research, Innovation and Higher Education (SIIES) of Yucatan. Mexico and the Secretariat of Research, Innovation and Higher Education (SIIES) of Yucatan. JCVU was financially supported by the pFIS Program (FI18/00315), MMG by a Clara Roy grant (SEIMC) and CLM by IN606A-2019/029Xunta de Galicia; 0474_BLUEBIOLAB_1_EXunta de Galicia; GRC2018/039Xunta de Galicia; ED431E 2018/03Xunta de Galicia; IN607A 2016/22Xunta de Galicia; IN606A-2019/02

Simulation of adaptation board cable connection spacecraft "Electro-L" № 3 upper overclocking block 11s861-03 with carrier rocket "Proton-M"

With SolidWorks software built a three-dimensional model of the frame mounting and installation on-board the spacecraft communication cable "Electro-L» № 3, carried out simulation and analysis of structural strength. For all received three-dimensional models using AutoCAD design documentation package was developed

Proteína Bm86 y su potencial uso como vacuna contra garrapatas en el ganado bovino. Revisión

Tick infestations represent a major difficulty for cattle production in tropical and subtropical countries around the world. The traditional ways to combat this pest are chemicals (acaricides) and integrated management of grasslands. Nevertheless, these methods have not been able to conclusively control the presence of this ectoparasite. This has led to the search for vaccines that allow the control of these parasites. Currently, there are immunogens containing the gut antigen Bm86 of Rhipicephalus microplus, which have proven to be an effective alternative, as they have reduced tick populations and the use of synthetic acaricides. However, the polymorphism of this locus in ticks from different geographical areas represents a limitation in its effectiveness. A significant number of studies have been conducted on the Bm86 gene as a vaccine antigen, so this paper presents an update on studies conducted with this antigen and its potential use as an immunological control to reduce tick infestations in cattle.Las infestaciones de garrapatas representan una gran dificultad para la producción de ganado bovino en países tropicales y subtropicales alrededor del mundo. Las formas tradicionales de combate a esta plaga son químicos (acaricidas) y manejo integral de pastizales. Sin embargo, estos métodos no han logrado controlar de manera contundente la presencia de este ectoparásito. Lo anterior ha llevado a la búsqueda de vacunas que permitan el control de estos parásitos. Actualmente, se cuenta con inmunógenos que contienen el antígeno intestinal Bm86 de Rhipicephalus microplus, los cuales han demostrado ser una alternativa efectiva, al reducir las poblaciones de garrapatas y el uso de acaricidas sintéticos. No obstante, el polimorfismo de este locus en garrapatas de distintas zonas geográficas representa una limitante en su efectividad. Se han realizado un número importante de investigaciones acerca del gen Bm86 como antígeno vacunal, por lo que, en este documento, se presenta una actualización de las investigaciones realizadas con este antígeno y su potencial uso como control inmunológico para reducir las infestaciones de garrapatas en el ganado bovino