Beneficial health effects of cumin (Cuminum cyminum) seeds upon incorporation as a potential feed additive in livestock and poultry: A mini-review

Cumin (Cuminum cyminum Linn) is an annual plant of the family Umbelliferae, with its use dating back to ancient times when it was cultivated for its medicinal and culinary potential. Cumin seeds could contain a wide variety of phytochemicals, including alkaloids, coumarins, anthraquinones, flavonoids, glycosides, proteins, resins, saponins, tannins, and steroids. In particular, linoleic acid, one of the unsaturated fatty acids found in abundance in cumin oleoresin, is credited with promoting good health. Many of cumin's purported biological actions in livestock and poultry have been attributed to flavonoids such as apigenin, luteolin, and glycosides. Cumin has several healthful qualities, such as antibacterial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, anti-diabetic, anti-platelet aggregation, hypotensive, bronchodilatory, immunological, anti-amyloidogenic, and anti-osteoporotic properties. Cumin supplementation may improve milk production and reproductive function in dairy cows by altering the feeding pattern of bacteria in the rumen, encouraging the growth of beneficial microbes, or stimulating the secretion of certain digestive enzymes. Because of the low price of cumin seed, it could be concluded that its inclusion in the diet might be beneficial to the commercial poultry industry and reduce the overall cost of egg and meat production. In recent years a rise in cumin's popularity has been seen as a result of the herbal movement spearheaded by naturopaths, yoga gurus, advocates of alternative medicine, and manufacturers of feed additives. Animal nutritionists are exploring the use of cumin for its potential to boost growth, improve nutrient usage efficiency, and reduce greenhouse gas emissions. This mini-review discusses how cumin could be used as a feed ingredient to boost productivity and ensure healthy animal reproduction

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Additional file 3: Figure S3. Regulation of genes of Arrhythmogenic right ventricular cardiomyopathy pathway during senescence induction in HFF strains Genes of the “Arrhythmogenic right ventricular cardiomyopathy” pathway which are significantly up- (green) and down- (red) regulated (log2 fold change >1) during irradiation induced senescence (120 h after 20 Gy irradiation) in HFF strains. Orange color signifies genes which are commonly up-regulated during both, irradiation induced and replicative senescence

Solubility of Anthracene in Binary Solvent Mixtures Containing Dibutyl Ether

Article on the solubility of anthracene in binary solvent mixtures containing dibutyl ether

VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements

Background: The genes that produce antibodies and the immune receptors expressed on lymphocytes are not germline encoded; rather, they are somatically generated in each developing lymphocyte by a process called V(D) J recombination, which assembles specific, independent gene segments into mature composite genes. The full set of composite genes in an individual at a single point in time is referred to as the immune repertoire. V(D) J recombination is the distinguishing feature of adaptive immunity and enables effective immune responses against an essentially infinite array of antigens. Characterization of immune repertoires is critical in both basic research and clinical contexts. Recent technological advances in repertoire profiling via high-throughput sequencing have resulted in an explosion of research activity in the field. This has been accompanied by a proliferation of software tools for analysis of repertoire sequencing data. Despite the widespread use of immune repertoire profiling and analysis software, there is currently no standardized format for output files from V(D) J analysis. Researchers utilize software such as IgBLAST and IMGT/High V-QUEST to perform V(D) J analysis and infer the structure of germline rearrangements. However, each of these software tools produces results in a different file format, and can annotate the same result using different labels. These differences make it challenging for users to perform additional downstream analyses. Results: To help address this problem, we propose a standardized file format for representing V(D) J analysis results. The proposed format, VDJML, provides a common standardized format for different V(D) J analysis applications to facilitate downstream processing of the results in an application-agnostic manner. The VDJML file format specification is accompanied by a support library, written in C++ and Python, for reading and writing the VDJML file format. Conclusions: The VDJML suite will allow users to streamline their V(D) J analysis and facilitate the sharing of scientific knowledge within the community. The VDJML suite and documentation are available from https:// vdjserver. org/ vdjml/. We welcome participation from the community in developing the file format standard, as well as code contributions.Burroughs Welcome Fund Career Award; NIAID [AI097403]; Bioinformatics Support Contract (BISC) [HHSN272201200028C]; National Institute of Allergy and Infectious Diseases grant [U19 AI090019, R01 AI104739]; PhRMA foundation pre-doctoral informatics fellowship; National Library of Medicine of the National Institutes of Health [T15 LM07056]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Influence of Donor Age and Species Longevity on Replicative Cellular Senescence

The replicative life span of cell strains obtained from multiple explants from the same individual is highly variable, additional variability is added when strains are obtained from different individuals. This variability is probably due to both technical issues and heterogeneity inside the tissues. Notwithstanding these limitations, many scientists searched for an inverse relationship of proliferative potential and donor age. Reviewing this literature, we conclude that this inverse correlation is likely more dependent to developmental stages than to aging per se; i.e. cells taken from a developing organism have higher replicative capacity than cells taken from an adult. Replicative senescence has been studied also across species searching for a positive relationship with longevity. Recently it has been show that when specific culture conditions (mainly low oxygen tension) are applied, strains from several species appear immortals. Moreover, for species that do present cellular senescence, it seems that replicative capacity relates primarily to species adult body mass more than to longevity