216 research outputs found

    A Canadian Lens on Third Party Litigation Funding in the American Bankruptcy Context

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    This Article offers two major recommendations to expand the use of third party litigation funding (“TPLF”) into the U.S. insolvency context. As seen in the Canadian context, courts have accepted the use of litigation funding agreements fitting within certain parameters. If U.S. courts follow suit, friction against the implementation of TPLF can be mitigated. Alternatively, regulation may occur through legislative and regulatory models to govern and set out precisely what types of arrangements are permitted. Involving entities such as the SEC may expedite the acceptance of TPLF, but special attention is necessary not to intermingle notions of fiduciaries into the discussion of TPLF, as there are contentious definitional elements present. Ultimately, a framework wherein regulation coupled with judicial oversight presents the best opportunity for the United States to adopt TPLF in the insolvency context to ensure maximum delivery of benefits to vulnerable parties

    PENGARUH KONTRAK PSIKOLOGIS DAN MOTIVASI KERJA TERHADAP KOMITMEN ORGANISASI GURU SMK NEGERI KABUPATEN LAMPUNG BARAT

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    The objective of this research is to obtain information about the effect of psychological contract and job motivation on teacher organization commitmen. It was quantitative research with survey method in SMK Negeri Kabupaten Lampung Barat.The research was conducted to all teacher of SMK Negeri Kabupaten Lampung Barat by using a survey method with path analysis applied in testing hypothesis. The number 154 teachers as sample was selected by using Slovin formula.The research conlude: (1) There is a direct positive effect of psychological contract on organization commitmen. (2) There is a direct positive effect of job motivation on organization commitmen. (3) There is a direct positive of psychological contract on job motivation

    P.E.E.L.: Proyecto de Esculturas como Espacio Lúdico

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    Proyecto que propone la posibilidad de recuperar y/o transformar una zona en deterioro a través de un conjunto de esculturas, diseñadas especialmente para promover la exploración, las relaciones y el aprendizaje lúdico.Shiroma Uza, A. (2008). P.E.E.L.: Proyecto de Esculturas como Espacio Lúdico. http://hdl.handle.net/10251/13528Archivo delegad

    Utilización de la moscovita proveniente de la zona Micasia del sur del Perú para su utilización en los revestimientos de electrodos para acero inoxidable, aws-asme sfa 5.4/ 5.4M

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    Inherentemente a la producción y al uso de los aceros inoxidables, una de las principales dificultades en este tipo de electrodos es el control del arco y no generar porosidades en los depósitos de soldadura. Muchos óxidos pueden ayudar a controlar esta dificultad y muchos minerales no metálicos pueden ser la solución y a veces lo ignoramos. En el presente artículo se plantea una alternativa con el empleo del mineral no metálico de forma sintética. Esta moscovita de poco valor frente a los minerales polimetálicos puede ser transformada incrementando los niveles KO2 dándosele un valor e incorporarla en el revestimiento de electrodos como estabilizador del arco que genera cordones de soldadura exentos de porosidades durante el soldeo en los electrodos especiales

    Circuito electrónico para máquina de soldar tipo inversor usando semiconductores mosfet’s para trabajos en zonas alto andinas

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    En las zonas alto andinas del Perú una de las dificultades que presentan las máquinas de soldar por arco eléctrico del tipo inversor es que trabajen eficientemente en alturas por encima de los 1000 msnm. La mayoría de los equipos que existen en nuestro medio son del tipo transformador de bajo ciclo de trabajo; existen otras máquinas de soldar de tipo inversor que presentan dificultad durante el soldeo debido a la poca fuerza del arco, siendo necesario incrementar los amperajes de trabajo. El presente artículo plantea una solución mediante el uso de semiconductores de tecnología MOSFET con rápida respuesta de conmutación y alta eficiencia

    In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy

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    Although checkpoint inhibitors (CPIs) have changed the paradigm of cancer therapy, low response rates and serious systemic adverse events remain challenging. In situ vaccine (ISV), intratumoral injection of immunomodulators that stimulate innate immunity at the tumor site, allows for the development of vaccines in patients themselves. K3-SPG, a second-generation nanoparticulate Toll-like receptor 9 (TLR9) ligand consisting of K-type CpG oligodeoxynucleotide (ODN) wrapped with SPG (schizophyllan), integrates the best of conventional CpG ODNs, making it an ideal cancer immunotherapy adjuvant. Focusing on clinical feasibility for pancreaticobiliary and gastrointestinal cancers, we investigated the antitumor activity of K3-SPG-ISV in preclinical models of pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC). K3-SPG-ISV suppressed tumor growth more potently than K3-ISV or K3-SPG intravenous injections, prolonged survival, and enhanced the antitumor effect of CPIs. Notably, in PDAC model, K3-SPG-ISV alone induced systemic antitumor effect and immunological memory. ISV combination of K3-SPG and agonistic CD40 antibody further enhanced the antitumor effect. Our results imply that K3-SPG-based ISV can be applied as monotherapy or combined with CPIs to improve their response rate or, conversely, with CPI-free local immunotherapy to avoid CPI-related adverse events. In either strategy, the potency of K3-SPG-based ISV would provide the rationale for its clinical application to puncturable pancreaticobiliary and gastrointestinal malignancies

    SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation.

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    Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocytic activity and chemotactic properties. The aim of this study was to investigate the role of SR-PSOX/CXCL16 in patients with IBD and experimental murine colitis
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