XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia

Background: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population

Radiation Safety Process for the Patient and People Around during Diagnostic Radionuclide Studies

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Radiation Safety Procedures For Non-Radiation Workers in Case of Application Radionuclide Therapy in the Dialysis Patients

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Analysis of the effects of ha-330 hemo adsorption column application on mortality and morbidity of adult patients with sepsis in general intensive care unit

Sepsis is a leading cause of mortality and morbidity in critical care units. The objective of this study is to evaluate if using the HA-330 Sepsis Adsorption Column in the intensive care unit reduces mortality and morbidity in patients with sepsis. This study was designed as a retrospective study evaluating demographic and laboratory parameters in the General Intensive Care Unit. The study involved 200 sepsis patients who were followed in the critical care unit between June 2019- December 2020 and were treated with the HA-330 Sepsis Adsorption Column. The length of hemoperfusion in patients who died was statistically significantly longer than in patients who recovered. The mean lactate and the hemoperfusion time/day value had a weak but significant negative correlation. In the recovery and death observations, the improvements in repeated C-reactive protein and Procalcitonin measurements were statistically significantly different. The differences in repeated pH and lactate measurements in the recovery and mortality observations were statistically identical, according to the observations. Sepsis-related deaths are a severe issue in critical care units. HA-330 Sepsis Adsorption Column, it can be thought that it can be an inexpensive, useful, and effective method that can be used in the prognosis of the patients. In antibiotic-resistant sepsis, hemoperfusion may be recommended. [Med-Science 2022; 11(1.000): 124-30

Physical Healthcare of People with Serious Mental Illness: A Cross-Sectional Study of Nurses' Involvement, Views, and Current Practices

Background: Based on the poor physical health and unhealthy lifestyle behaviors, people with serious mental illness (SMI) have a high risk for long-term disorders such as diabetes, cardiovascular and respiratory diseases. Aims: This study examined nurses' current practices and views regarding the physical health of people with SMI. Methods: Cross-sectional study was conducted among nurses working in acute wards in large mental health hospital in Istanbul, Turkey. Convenience sample of 184 nurses agreed to participate in the study. Data collection was based on the self-reported responses. Descriptive statistics and comparison tests were used to describe the sample's characteristics and identify associations amongst the participants' characteristics. Findings: The results showed that nurses considered the patients' physical health important, particularly female nurses. Monitoring blood pressure, assessing physical health status at admission, and helping self-care needs were common practices. Believing in the importance of physical health was correlated with high knowledge and self-confidence levels in delivery of physical healthcare. Discussion: These findings are useful for implementing integrated nursing care in acute psychiatric care and improving patients' mental and physical well-being

Initial psychometric evaluation of the physical health attitude scale and a survey of mental health nurses

Accessible summaryWhat is known on the subject

An examination of effects of intimate partner violence on children: A cross-sectional study conducted in a paediatric emergency unit in Turkey

BackgroundIntimate partner violence (IPV) against women causes inadequate and unbalanced nutrition in children aged 0–5 years and adversely affects their growth.AimTo examine the impact of intimate partner violence on a child’s growth regarding the medical diagnosis in paediatric patients under 5 years of age, growth of the child, and the mother’s exposure to intimate partner violence.MethodsThis descriptive cross-sectional study included 166 children admitted to a paediatric emergency department, and their mothers.ResultsWomen exposed to emotional violence and controlling behaviour during pregnancy had children prone to being overweight and obese. A mothers lifetime exposure to physical violence had an adverse effect on their children’s wasting and moderate wasting. In contrast, mothers’ exposure to emotional violence had a direct impact on a child’s wasting and moderate wasting.ConclusionThe lifetime effect of domestic violence may begin at birth. This vulnerability leads to negative outcomes in both children and women regarding biopsychosocial development.Implications for nursing managementNurses and midwives in primary health care services and one-on-one care should be trained to evaluate prospective mothers and children aged 0–5 regarding violence and its effects on the child’s growth.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/174938/1/jonm13673_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/174938/2/jonm13673.pd

Stress distribution and damage mode of ceramic-dentin bilayer systems

The aim of this study was to evaluate the damage modes of ceramic systems bonded to dentin under Hertzian indentation. Single-cycle Hertzian contact test over 150-850 N load range was applied randomly to 210 ceramic-dentin bilayer disc specimens of zirconia or IPS Empress II -1 mm, -1.5 mm and of feldspathic porcelain -1 mm, -1.5 mm, -2 mm. Optical microscopy was employed for the identification of quasiplastic mode and radial cracks. Finite element analysis was used to analyze the stress distribution. Our results showed that the degree of damage in both modes evolved progressively and the origin changed with contact load. Stress location and value were consistent with the mechanical test results. It was concluded that microstructure and thickness of the material have a significant effect on the damage modes of ceramic layer systems