Evidence for dynamic network regulation of Drosophila photoreceptor function from mutants lacking the neurotransmitter histamine

Synaptic feedback from interneurons to photoreceptors can help to optimize visual information flow by balancing its allocation on retinal pathways under changing light conditions. But little is known about how this critical network operation is regulated dynamically. Here, we investigate this question by comparing signaling properties and performance of wild-type Drosophila R1-R6 photoreceptors to those of the hdcJK910 mutant, which lacks the neurotransmitter histamine and therefore cannot transmit information to interneurons. Recordings show that hdcJK910 photoreceptors sample similar amounts of information from naturalistic stimulation to wild-type photoreceptors, but this information is packaged in smaller responses, especially under bright illumination. Analyses reveal how these altered dynamics primarily resulted from network overload that affected hdcJK910 photoreceptors in two ways. First, the missing inhibitory histamine input to interneurons almost certainly depolarized them irrevocably, which in turn increased their excitatory feedback to hdcJK910 R1-R6s. This tonic excitation depolarized the photoreceptors to artificially high potentials, reducing their operational range. Second, rescuing histamine input to interneurons in hdcJK910 mutant also restored their normal phasic feedback modulation to R1-R6s, causing photoreceptor output to accentuate dynamic intensity differences at bright illumination, similar to the wild-type. These results provide mechanistic explanations of how synaptic feedback connections optimize information packaging in photoreceptor output and novel insight into the operation and design of dynamic network regulation of sensory neurons

Fly Photoreceptors Encode Phase Congruency

More than five decades ago it was postulated that sensory neurons detect and selectively enhance behaviourally relevant features of natural signals. Although we now know that sensory neurons are tuned to efficiently encode natural stimuli, until now it was not clear what statistical features of the stimuli they encode and how. Here we reverse-engineer the neural code of Drosophila photoreceptors and show for the first time that photoreceptors exploit nonlinear dynamics to selectively enhance and encode phase-related features of temporal stimuli, such as local phase congruency, which are invariant to changes in illumination and contrast. We demonstrate that to mitigate for the inherent sensitivity to noise of the local phase congruency measure, the nonlinear coding mechanisms of the fly photoreceptors are tuned to suppress random phase signals, which explains why photoreceptor responses to naturalistic stimuli are significantly different from their responses to white noise stimuli

Laser based observation of space debris: Taking benefits from the fundamental wave

After the successful experimental demonstration of the prior published concept on laser-based monitoring of space debris in early 2012, we will present further technological and conceptual advancements of this position sensing scheme. The laser based measurement of LEO space debris positions in general offers the potential of a very high accuracy on the order of 10 meters in 3D, which in turn is the input for orbit processing of objects which are seemingly on collisional course. We argue that it is beneficial for the photon budget to make use of the so called fundamental wave, which is present in frequency doubled laser systems anyway. Thus, the here proposed move to near infrared wavelength is technologically easy to achieve and promising towards an operational laser-based debris ranging and tracking system

Bulgarian-Turkish relations in the summer of 1915.

Donated by Klaus KreiserReprinted from : Balkan Studies 18, 1977

Laser measurements to space debris from Graz SLR station

In order to test laser ranging possibilities to space debris objects, the Satellite Laser Ranging (SLR) Station Graz installed a frequency doubled Nd:YAG pulse laser with a 1 kHz repetition rate, a pulse width of 10 ns, and a pulse energy of 25 mJ at 532 nm (on loan from German Aerospace Center Stuttgart – DLR). We developed and built low-noise single-photon detection units to enable laser ranging to targets with inaccurate orbit predictions, and adapted our standard SLR software to include a few hundred space debris targets. With this configuration, we successfully tracked – within 13 early-evening sessions of each about 1.5 h – 85 passes of 43 different space debris targets, in distances between 600 km and up to more than 2500 km, with radar cross sections from >15 m² down to <0.3 m², and measured their distances with an average precision of about 0.7 m RMS