46 research outputs found

    Extremely skewed X-chromosome inactivation patterns in women with recurrent spontaneous abortion

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    Background: The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of recurrent spontaneous abortion (RSA) but the results obtained were conflicting. Aims: We therefore investigated the XCI patterns in peripheral blood DNA obtained from 80 patients who had RSA and 160 age-matched controls. Methods: Pregnancy history, age, karyotype, and disease information was collected from all subjects. The methylation status of a highly polymorphic cytosine-adenine-guanine repeat in the androgen-receptor (AR) gene was determined by use of methylation-sensitive restriction enzyme HpaII and polymerase chain reaction. Results: Skewed XCI (> 8 5% skewing) was observed in 13 of the 62 patients informative for the AR polymorphism (20.9%), and eight of the 124 informative controls (6.4%) (P = 0.0069; χ 2 test). More importantly, extremely skewed XCI, defined as > 90% inactivation of one allele, was present in 11 (17.7%) patients, and in only two controls (P = 0.0002; χ 2 test). Conclusions: These results support the interpretation that disturbances in XCI mosaicism may be involved in the pathogenesis of RSA. © 2006 The Authors Journal compilation © 2006 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists

    Combination of searches for Higgs boson pair production in pp collisions at √s = 13 TeV with the ATLAS detector

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    This Letter presents results from a combination of searches for Higgs boson pair production using 126–140 fb−1 of proton-proton collision data at √s = 13 TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.4 assuming no Higgs boson pair production. Constraints on the Higgs boson self-coupling modifier κλ = λHHH=λSM HHH, and the quartic HHVV coupling modifier κ2V = gHHVV=gSM HHVV, are derived individually, fixing the other parameter to its SM value. The observed 95% CL intervals are −1.2 < κλ < 7.2 and 0.6 < κ2V < 1.5, respectively, while the expected intervals are −1.6 < κλ < 7.2 and 0.4 < κ2V < 1.6 in the SM case. Constraints obtained for several interaction parameters within Higgs effective field theory are the strongest to date, offering insights into potential deviations from SM predictions

    Combination of searches for Higgs boson decays into a photon and a massless dark photon using pp collisions at √s = 13 TeV with the ATLAS detector

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    A combination of searches for Higgs boson decays into a visible photon and a massless dark photon (H → γγd) is presented using 139 fb−1 of proton-proton collision data at a centre-of-mass energy of √s = 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The observed (expected) 95% confidence level upper limit on the Standard Model Higgs boson decay branching ratio is determined to be B(H → γγd) < 1.3% (1.5)%. The search is also sensitive to higher-mass Higgs bosons decaying into the same final state. The observed (expected) 95% confidence level limit on the cross-section times branching ratio ranges from 16 fb (20 fb) for mH = 400 GeV to 1.0 fb (1.5 fb) for mH = 3 TeV. Results are also interpreted in the context of a minimal simplified model

    Search for dark mesons decaying to top and bottom quarks in proton-proton collisions at √s = 13 TeV with the ATLAS detector

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    A search for dark mesons originating from strongly-coupled, SU(2) dark favor symmetry conserving models and decaying gaugephobically to pure Standard Model final states containing top and bottom quarks is presented. The search targets fully hadronic final states and final states with exactly one electron or muon and multiple jets. The analyzed data sample corresponds to an integrated luminosity of 140 fb−1 of proton-proton collisions collected at √s = 13 TeV with the ATLAS detector at the Large Hadron Collider. No significant excess over the Standard Model background expectation is observed and the results are used to set the first direct constraints on this type of model. The two-dimensional signal space of dark pion masses mπD and dark rho-meson masses mρD is scanned. For mπD /mρD = 0.45, dark pions with masses mπD < 940 GeV are excluded at the 95% CL, while for mπD /mρD = 0.25 masses mπD < 740 GeV are excluded

    Search for decays of the Higgs boson into a pair of pseudoscalar particles decaying into bb¯τ+τ− using pp collisions at √s = 13 TeV with the ATLAS detector

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    This paper presents a search for exotic decays of the Higgs boson into a pair of new pseudoscalar particles, H → aa, where one pseudoscalar decays into a b-quark pair and the other decays into a τ-lepton pair, in the mass range 12 ≤ ma ≤ 60 GeV. The analysis uses pp collision data at √s = 13 TeV collected with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 140 fb−1. No significant excess above the Standard Model (SM) prediction is observed. Assuming the SM Higgs boson production cross section, the search sets upper limits at 95% confidence level on the branching ratio of Higgs bosons decaying into bb¯ τ+τ−, B(H → aa → bb¯ τ+τ−), between 2.2% and 3.9% depending on the pseudoscalar mass

    Measurement of single top-quark production in association with a W boson in pp collisions at √s = 13 TeV with the ATLAS detector

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    The inclusive cross section for the production of a single top quark in association with a W boson is measured using 140 fb−1 of proton-proton collision data collected with the ATLAS detector at √s = 13 TeV. Events containing two charged leptons and at least one jet identified as originating from a b-quark are selected. A multivariate discriminant is constructed to separate the tW signal from the t¯t background. The cross section is extracted using a profile likelihood fit to the signal and control regions and it is measured to be σtW = 75+15 −14 pb, in good agreement with the Standard Model prediction. The measured cross section is used to extract a value for the left-handed form factor at the Wtb vertex times the Cabibbo-Kobayashi-Maskawa matrix element |fLVVtb| of 0.97 0.10

    Combination of searches for Higgs boson decays into a photon and a massless dark photon using pp collisions at √s = 13 TeV with the ATLAS detector

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    A combination of searches for Higgs boson decays into a visible photon and a massless dark photon (H → γγd) is presented using 139 fb−1 of proton-proton collision data at a centre-of-mass energy of √s = 13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The observed (expected) 95% confidence level upper limit on the Standard Model Higgs boson decay branching ratio is determined to be B(H → γγd) < 1.3% (1.5)%. The search is also sensitive to higher-mass Higgs bosons decaying into the same final state. The observed (expected) 95% confidence level limit on the cross-section times branching ratio ranges from 16 fb (20 fb) for mH = 400 GeV to 1.0 fb (1.5 fb) for mH = 3 TeV. Results are also interpreted in the context of a minimal simplified model

    Search for dark mesons decaying to top and bottom quarks in proton-proton collisions at √s = 13 TeV with the ATLAS detector

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    A search for dark mesons originating from strongly-coupled, SU(2) dark favor symmetry conserving models and decaying gaugephobically to pure Standard Model final states containing top and bottom quarks is presented. The search targets fully hadronic final states and final states with exactly one electron or muon and multiple jets. The analyzed data sample corresponds to an integrated luminosity of 140 fb−1 of proton-proton collisions collected at √s = 13 TeV with the ATLAS detector at the Large Hadron Collider. No significant excess over the Standard Model background expectation is observed and the results are used to set the first direct constraints on this type of model. The two-dimensional signal space of dark pion masses mπD and dark rho-meson masses mρD is scanned. For mπD /mρD = 0.45, dark pions with masses mπD < 940 GeV are excluded at the 95% CL, while for mπD /mρD = 0.25 masses mπD < 740 GeV are excluded

    Determination of different growth media and various mycorrhizae species on citrus growth and nutrient uptake

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    The influence of mycorrhiza species and growing media (GM) on the growth and nutrient uptake of citrus seedlings (sour orange (Citrus aurantium L.)) was studied. The experiments were conducted over 10 months using: four growth media, eight mycorrhiza species, one cocktail of mycorrhizae spores and one indigenous mycorrhiza spore (collected from the citrus orchard rhizosphere). Four different growing media were tested under controlled greenhouse conditions: GM-A, andesitic tuff. +. peat (1:1, v/v); GM-B, andesitic tuff. +. compost (1:1, v/v); GM-C, andesitic tuff. +. peat. +. compost (2:1:1, v/v/v) and GM-D andesitic tuff. +. peat. +. soil (from the Balcali{dotless} region) (2:1:1, v/v/v).After a 10 month growing period, the highest values of leaf number, height, shoots and root dry weight were found in GM-C, followed by GM-A and GM-D; whereas the lowest values were found using the GM-B treatment. The results reveal that mycorrhizal inoculation increased the shoot and root dry weight production, compared with the levels found in non-inoculated plants. It was observed that various mycorrhiza species exhibit different responses when varying the growth media; it was also observed that G. clarium, G. margarita, Glomus mosseae, Dr. Kindom (commercial inoculum) and indigenous mycorrhiza (IM) are efficient mycorrhizae species for seedling growth. Mycorrhiza-inoculated citrus seedlings contained a higher content of phosphorus (P), zinc (Zn) than non-inoculated plants. © 2014.This research was funded by the Çukurova University Research Fund . We would also like to thank Dr Liz Rees for proofreading this work
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