39 research outputs found

    Systemic Immune-Inflammatory Index as a Determinant of Atherosclerotic Burden and High-Risk Patients with Acute Coronary Syndromes

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    Background: Systemic immune-inflammatory index (SII), which is derived from neutrophil, platelet and lymphocyte counts, represents the homeostatic balance among inflammatory, immune and thrombotic status. The systemic immune-inflammatory index is superior to indices such as neutrophil-lymphocyte ratio in predicting prognosis in various malignancies, while it is shown to predict future cardiac events better than traditional risk factors after coronary intervention. Objectives: Herein, we aimed to evaluate the relationship of the systemic immune-inflammatory index with atherosclerotic burden and in-hospital complications in acute coronary syndrome patients. Methods: The clinical outcomes, such as extent of myocardial damage, atherosclerotic burden, bleeding, acute kidney injury, duration of hospital stay and in-hospital mortality, were evaluated in a retrospective cohort of 309 consecutive acute coronary syndrome patients. The systemic immune-inflammatory index was calculated as (Platelet X Neutrophil)/Lymphocyte count on admission. Study population was categorized into tertiles with regard to systemic immune-inflammatory index. A p value of <0.05 was considered statistically significant. Results: The highest systemic immune-inflammatory index values were within ST elevation myocardial infarction patients (641.4 in unstable angina pectoris, 843.0 in non-ST elevation myocardial infarction patients and 996.0 in ST elevation myocardial infarction patients; p=0.004). Maximal troponin concentration (0.94 vs. 1.26 vs. 3; p<0.001), number of diseased vessels (1 vs. 2 vs. 2; p<0.001), the SYNTAX (synergy between percutaneous coronary intervention with taxus and coronary artery bypass grafting) score (9 vs. 14 vs. 17.5; p<0.001) and duration of hospital stay (2 vs. 2 vs. 3; p<0.001) also increased with increasing SIItertile (tertile1 vs. tertile 2 vs. tertile 3). Systemic immune-inflammatory index was an independent predictor of SYNTAX score (B: 0.232 [0.001 to 0.003]; p<0.001), extent of myocardial damage (B: 0.152 [0 to 0.001]; p=0.005) and duration of hospital stay (B: 0.168 [0.0 to 0.001]; p=0.003). Conclusions: This study has demonstrated that the systemic immune-inflammatory index, a simple hematological index, is a marker of atherosclerotic burden and longer hospital stay on well-known risk factors in high risk acute coronary syndrome patients

    VERİ MADENCİLİĞİ İLE BİLGİSAYAR AĞLARINDA YENİ BİR SALDIRI TESPİT ALGORİTMASI

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    Bu çalışmada veri madenciliği tekniklerinden biri olan karar ağaçlarıyla bilgisayar ağlarında yeni bir saldırı tespit algoritması geliştirilmiştir. Standart ID3 ve önerilen algoritmaya göre oluşturulmuş karar ağaçları KDD Cup'99 verisiyle test edilmiş ve her iki algoritmanın saldırı tespit başarımlarının raporlanması gerçeklenmiştir. Deneysel sonuçlardan da görüldüğü üzere yeni önerilen algoritmanın şu an uygulamada kullanılan ID3 algoritmasından daha iyi bir başarım gösterdiği görülmüştür.In this study, a new intrusion detection algorithm in computer networks has been developed with decision trees which is one of the data mining techniques. Decision trees which are generated according to standard ID3 and proposed algorithm have been tested with KDD Cup'99 test data sets and both of these algorithms' performance of intrusion detection has been reported. As the experimental studies show the proposed algorithm has become more successful than the standard ID3 algorithm

    Huzurevinde yaşayan yaşlılarda ağrı özellikleri, ağrı inançları ve depresyon riskinin belirlenmesi

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    Introduction: The aim of this study was to determine pain frequency, pain characteristics, pain beliefs and depression status of elderly people living in nursing homes. Materials and Method: This descriptive study was carried out in nursing homes affiliatedwith Istanbul Metropolitan Municipality. Elderly people who were residents in these nursing homes were included in the study. Data were collected with the Descriptive Data Form, Pain Evaluation Form, Geriatric Depression Scale and Pain Beliefs Questionnaire. Results: One hundred forty-six people were included in the study. 76% of the elderly peoplecomplained about pain, especially leg pain. This was severe chronic pain of a high intensity . This chronic pain adversely affected their daily activities. The risk of depression even higher in older patients with neurological disease. Half of the elderly residents (51%)stated that it was easier to cope with the pain when they were happy, and also that pain was anindicator of having something wrong with their body. Conclusion: In the light of this study, we can say that pain is a frequently seen symptom inelderly residents living in nursing homes. The psychological status of the residents has a great impact on the management of their pain. Therefore people's psychological status and their beliefsrelated to pain should also be assessed.Giriş: Bu araştırmanın amacı huzurevinde yaşayan yaşlılarda ağrı sıklığı, ağrı inançları ve depresyon riskini değerlendirmektir.Gereç ve Yöntem: Tanımlayıcı olarak planlanan bu araştırma İstanbul Büyükşehir Belediyesi'ne bağlı huzurevlerinde yapıldı. Veriler, Tanıtıcı Veri Formu, Ağrı Değerlendirme Formu, GeriatrikDepresyon Ölçeği ve Ağrı İnançları ölçeği ile toplandı.Bulgular: Çalışmaya 146 birey dahil edildi. Huzurevinde yaşayan yaşlıların %76'sında en çokbacak bölgesinde yerleşim gösteren ve 5-7 şiddetinde (Numerical Rating Scale) olan, günlük aktivitelerini olumsuz yönde etkileyen kronik ağrıları olduğu saptandı. Depresyon riski nörolojik hastalığı olan yaşlılarda daha yüksek olarak saptandı (p=0,020). Yaşlıların yarısı (%51,0) "mutlu iken ağrı ile baş etmenin daha kolay" olduğuna ve "ağrı çekmenin vücutta bir şeylerin ters gittiğinin işareti" olduğuna inanmaktadır.Sonuç: Bu çalışmanın ışığı altında huzurevinde yaşayan yaşlılarda ağrının sık görülen bir semptom olduğu söylenebilir. Bireyin psikolojik durumunun ağrı yönetimi üzerinde büyük bir etkisi olduğu görülmüştür. Bu nedenle bireylerin psikolojik durumları ve ağrı inançları da değerlendirilmelidir

    DETERMINATION OF PAIN CHARACTERISTICS, PAIN BELIEF AND RISK OF DEPRESSION AMONG ELDERLY RESIDENTS LIVING AT NURSING HOME

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    Introduction: The aim of this study was to determine pain frequency, pain characteristics, pain beliefs and depression status of elderly people living in nursing homes

    Bevacizumab plus Capecitabine as Maintenance Therapy after Initial Bevacizumab plus XELOX Treatment in Previously Untreated Patients with Metastatic Colorectal Cancer: Phase Ill 'Stop and Go' Study Results - A Turkish Oncology Group Trial

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    WOS: 000329268000003PubMed ID: 24247559Objective: It was the aim of this study to evaluate maintenance therapy with bevacizumab + capecitabine following induction with bevacizumab + capecitabine + oxaliplatin (XELOX) versus bevacizumab + XELOX until progression as first-line therapy in metastatic colorectal cancer (mCRC). Methods: Patients received either bevacizumab (7.5 mg/kg) + XELOX (capecitabine 1,000 mg/m(2) twice daily on days 1-14 + oxaliplatin 130 mg/m2 on day 1 every 3 weeks) until disease progression (arm A) or the same doses of bevacizumab + XELOX for 6 cycles followed by bevacizumab + capecitabine until disease progression (arm B). The primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS), objective response rate (ORR) and safety. Results: One hundred and twenty-three patients were randomized. Treatment compliance was similar in both groups. Median PFS was significantly longer for arm B than for arm A (11.0 vs. 8.3 months; p = 0.002). There was no significant difference between the two arms for ORR (66.7 vs. 59.0%; p = 0.861) or median OS (23.8 vs. 20.2 months; p = 0.100). Tolerability was acceptable in both treatment arms; the most frequent grade 3/4 treatment-related adverse events (arm B vs. arm A) were fatigue (6.6 vs. 16.1%), diarrhoea (3.3 vs. 11.3%), anorexia (3.3 vs. 11.3%), and neuropathy (1.6 vs. 8.1%). Conclusions: Maintenance therapy with bevacizumab + capecitabine can be considered an appropriate option following induction bevacizunnab + XELOX in patients with mCRC instead of continuation of bevacizumab + XELOX. (C) 2013 S. Karger AG, BaselF. Hoffmann-La RocheHoffmann-La RocheFunding for the study and support for third-party writing assistance for the manuscript were provided by F. Hoffmann-La Roche
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