Esse y sta: selección de auxiliar en el dialecto del Aquila

This paper presents data on auxiliary selection in Aquilan dialect. It focuses on the two auxiliary verbs esse and sta, which respectively express a permanent and temporary property that holds for a given predicate. The goals of the paper are twofold. A first goal is to offer data on the distribution of these auxiliary verbs, filling an empirical void in the literature. A second goal is to offer a formal syntactic and semantic treatment of these two auxiliaries. This treatment is shown to make several predictions on the properties of these auxiliaries, and their interaction with other parts of speech.En este trabajo se presentan datos sobre la selección de auxiliar en el dialecto del Aquila. Se centra en los dos verbos auxiliares esse y esta, que respectivamente expresan una característica permanente y temporal que se mantiene para un predicado dado. Los objetivos del artículo son dos. El primero es ofrecer datos sobre la distribución de estos verbos auxiliares, llenando un vacío empírico en la bibliografía. El segundo es ofrecer un tratamiento formal de carácter sintáctico y semántico de estos dos auxiliares. Este tratamiento permite hacer varias predicciones sobre las propiedades de estos auxiliares y su interacción con otras partes del discurso

The NuSTAR view of the Seyfert Galaxy HE 0436-4717

We present the multi epoch spectral analysis of HE 0436-4717, a bright Seyfert 1 galaxy serendipitously observed by the high energy satellite NuSTAR four times between December 2014 and December 2015. The source flux shows modest variability within each pointing and among the four observations. Spectra are well modelled in terms of a weakly variable primary power law with constant photon index ($\Gamma$=2.01$\pm$0.08). A constant narrow \ion{Fe} K$\alpha$ emission line suggests that this feature has an origin far from the central black hole, while a broad relativistic component is not required by the data. The Compton reflection component is also constant in flux with a corresponding reflection fraction R=0.7$^{+0.2}_{-0.3}$. The iron abundance is compatible with being Solar (A$_{Fe}$=1.2$^{+1.4}_{-0.4}$), and a lower limit for the high energy cut-off E$_c$>280 keV is obtained. Adopting a self-consistent model accounting for a primary Comptonized continuum, we obtain a lower limit for the hot corona electron temperature kT$_e$>65 keV and a corresponding upper limit for the coronal optical depth of $\tau_e$<1.3. The results of the present analysis are consistent with the locus of local Seyfert galaxies in the kT$_e$-$\tau_e$ and temperature-compactness diagrams.Comment: accepted for publication in A&

Swift/XRT- NuSTAR spectra of type 1 AGN]{Swift/XRT- NuSTAR spectra of type 1 AGN: confirming INTEGRAL results on the high energy cut-off

We present the 0.5 - 78 keV spectral analysis of 18 broad line AGN belonging to the INTEGRAL complete sample. Using simultaneous Swift-XRT and NuSTAR observations and employing a simple phenomenological model to fit the data, we measure with a good constraint the high energy cut-off in 13 sources, while we place lower limits on 5 objects. We found a mean high-energy cut-off of 111 keV (standard deviation = 45 keV) for the whole sample, in perfect agreement with what found in our previous work using non simultaneous observations and with what recently published using NuSTAR data. This work suggests that simultaneity of the observations in the soft and hard X-ray band is important but not always essential, especially if flux and spectral variability are properly accounted for. A lesser agreement is found when we compare our cut-off measurements with the ones obtained by Ricci et al. (2017) using Swift-BAT high energy data, finding that their values are systematically higher than ours. We have investigated whether a linear correlation exists between photon index and the cut-off and found a weak one, probably to be ascribed to the non perfect modelling of the soft part of the spectra, due to the poor statistical quality of the 2-10 keV X-ray data. No correlation is also found between the Eddington ratio and the cut-off, suggesting that only using high statistical quality broad-band spectra is it possible to verify the theoretical predictions and study the physical characteristics of the hot corona and its geometry.Comment: 12 pages, 11 figures, accepted for publication in Monthly Notices of the Royal Astronomical Societ

Which Side are You On? The Worlds of Grant Morrison

Grant Morrison is a key figure among the first wave of authors of the so-called British Generation (Sandifer and Eklund). The works of the other two creators, Neil Gaiman and Alan Moore, have been the basis for a wealth of scholarly research within the field of comics studies and whole constellations of literary scholarship (Sandifer and Eklund; Sanders; Krueger and Shaeffer; Millidge). Morrison\u27s fictional worlds, however, remain understudied, despite the fact that, as Marc Singer observes, Morrison\u27s work and career seem to be evenly distributed along a continuum ranging from the alternative Vertigo material to the mainstream superhero comics (Singer 10-30). Furthermore, what should be of interest to comics scholars is the peculiar character of Morrison\u27s method, which seems to lie in his unique approach to the creative process. A chaos magician, shrewd comic entrepreneur, self-proclaimed geek and a closet workaholic, Morrison has always juggled several projects at once, often transferring ideas and concepts across series as a result, using subtle references to Borges and Calvino together with obscure mentions of silver age characters of DC comics, as for instance Buddy Baker/Animal Man (Callahan; Shapira). Since Morrison has spread his intense commitment to artistic production over a vast continuum of work, the net result is that the boundaries between mainstream and alternative productions have become thin

Investigating the X-ray polarization of lamp-post coronae in BHXRB

High-sensitivity X-ray polarimetric observations of black hole X-ray binaries, which will soon become available with the launches of space-borne X-ray observatories with sensitive X-ray polarimeters, will be able to put independent constraints on the black hole as well as the accretion flow, and possibly break degeneracies that cannot be resolved by spectral/timing observations alone. In this work we perform a series of general relativistic Monte-Carlo radiative transfer simulations to study the expected polarization properties of X-ray radiation emerging from lamp-post coronae in black hole X-ray binaries. We find that the polarization degree of the coronal emission of black hole X-ray binaries is sensitive to the spin of the black hole, the height of the corona, and the dynamics of the corona.Comment: Accepted for publication in MNRA

Location-Dependent Human Osteoarthritis Cartilage Response to Realistic Cyclic Loading: Ex-Vivo Analysis on Different Knee Compartments

Objective: Osteoarthritis (OA) is a multifactorial musculoskeletal disorder affecting mostly weight-bearing joints. Chondrocyte response to load is modulated by inflammatory mediators and factors involved in extracellular cartilage matrix (ECM) maintenance, but regulatory mechanisms are not fully clarified yet. By using a recently proposed experimental model combining biomechanical data with cartilage molecular information, basally and following ex-vivo load application, we aimed at improving the understanding of human cartilage response to cyclic mechanical compressive stimuli by including cartilage original anatomical position and OA degree as independent factors. Methods: 19 mono-compartmental Knee OA patients undergoing total knee replacement were recruited. Cartilage explants from four different femoral condyles zones and with different degeneration levels were collected. The response of cartilage samples, pooled according to OA score and anatomical position was tested ex-vivo in a bioreactor. Mechanical stimulation was obtained via a 3-MPa 1-Hz sinusoidal compressive load for 45-min to replicate average knee loading during normal walking. Samples were analysed for chondrocyte gene expression and ECM factor release. Results: Non parametric univariate and multivariate (generalized linear mixed model) analysis was performed to evaluate the effect of compression and IL-1β stimulation in relationship to the anatomical position, local disease severity and clinical parameters with a level of significance set at 0.05. We observed an anti-inflammatory effect of compression inducing a significant downmodulation of IL-6 and IL-8 levels correlated to the anatomical regions, but not to OA score. Moreover, ADAMTS5, PIICP, COMP and CS were upregulated by compression, whereas COL-2CAV was downmodulated, all in relationship to the anatomical position and to the OA degree. Conclusion: While unconfined compression testing may not be fully representative of the in-vivo biomechanical situation, this study demonstrates the importance to consider the original cartilage anatomical position for a reliable biomolecular analysis of knee OA metabolism following mechanical stimulation

Tinea incognito Caused by Microsporum gypseum in a Patient with Advanced HIV Infection: A Case Report

The prevalence and the clinical relevance of dermatophytoses in HIV-infected patients are poorly documented, particularly for those caused by tinea incognito. Here, we report a case of widespread facial tinea incognito occurring in an Italian patient with advanced HIV infection, showing both skin and brain lesions. Second-line treatment with liposomal amphotericin B and cotrimoxazole, administered after a microbiological characterization of the skin scrapings, led to complete clearance of all lesions

Prevalence and characteristics of diffuse idiopathic skeletal hyperostosis (DISH) in Italy

Purpose Diffuse idiopathic skeletal hyperostosis (DISH) is a benign condition characterized by ossification of the spine and prominent enthesopathies. Highly heterogeneous epidemiological figures have been reported in the literature, while in Italy the largest study has been conducted in 1992. The aim of our research is to contribute updated information about prevalence of DISH in Italy and to describe the clinical and radiographic characteristics associated with the disorder. Material and methods A retrospective review of lumbosacral spine, thoracic spine and pelvis radiographs was performed. Consecutive patients visiting the emergency department of our Institution over 3 years were enrolled. Presence of DISH was evaluated applying the Resnick and Niwayama criteria. Clinical and radiological features were also assessed. Results We included 1012 individuals (60.6% women), and DISH was present in 130 cases. The overall prevalence of DISH was 12.8% (95% CI 10.8-15.1), with higher figures in the male sample (16.8%) than in females (10.3%). In binary logistic regression adjusted for age, BMI (OR 1.50, p &lt; 0.001) diabetes (OR 1.85, p = 0.003), hypertension (OR 2.04, p = 0.007) ischiopubic enthesopathy (OR 7.08, p &lt; 0.001), iliac crest enthesopathy (OR 4.63, p &lt; 0.001) and greater trochanter enthesopathy (OR 3.51, p &lt; 0.001), were significantly associated with the condition. Conclusion The prevalence of DISH observed in our study is consistent with previous literature, and we confirm that the disorder is more frequently retrieved in men and that it is associated with the presence of metabolic disorders and pelvic enthesopathy. Knowledge about the epidemiology and characteristics of DISH is needed to properly identify the condition

Efficacy of 1998 <i>vs</i> 2006 first-line antiretroviral regimens for HIV infection: an ordinary clinics retrospective investigation

Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in ordinary clinical settings. Methods: Retrospective analysis of data of all patients starting first-line HAART regimens in 1998 and 2006 at adhering centers in the Italian CISAI group. Results: For the 543 patients included, mean age was 39.1 ± 9.8y in 1998 and 41.0 ± 10.7y in 2006 (p=0.03), with a similar proportion of males. Baseline mean log10 HIV-RNA was 4.56 ± 0.97 copies/mL in 1998 vs 4.91 ± 0.96 copies/mL in 2006 (p&lt;0.001); baseline mean CD4 T-cell counts were 343 ± 314/mm3 in 1998 vs 244 ± 174/mm3 in 2006 (p&lt;0.001). The following outcomes were significantly improved at 48w in 2006: proportion with undetectable HIV-RNA (86.3% vs 58.0%; p&lt;0.001); mean increase in CD4 T-cells count (252 ± 225 vs 173 ± 246; p&lt;0.001); HAART modification (20.1% vs 29.2%; p=0.02); HAART interruption (7.3% vs 14.6%; p=0.01); proportion reporting optimal adherence (92.2% vs 82.7%, p=0.03). No differences were observed in the prevalence of grade 3-4 WHO toxicities (26.4% vs 26.6%; p=0.9). Multivariate logistic regression showed that being treated in 1998 remained an independent predictor of virological failure after several adjustments, including adherence. Conclusions: Our data from patients not included in clinical trials or cohort studies provide an additional line of evidence that the effectiveness of HAART significantly improved in 2006. Treated patients, however, were significantly older and more frequently late HIV presenters in 2006 than in 1998.</br