Case Report: Lymphocytosis Associated With Fatal Hepatitis in a Thymoma Patient Treated With Anti-PD1: New Insight Into the Immune-Related Storm

Recent advances in tumor immunotherapy have made it possible to efficiently unleash immune effectors, reacting against neoplastic cells. Although these approaches primarily aim to eradicate malignancy, immune-related adverse events (irAEs) often influence patients’ prognosis, constituting a new spectrum of side effects. Taking into account the typical microenvironment and the intricate equilibrium between the anti-tumor response and the immune cells, the thymoma constitutes a unicum in the immune-oncology field. We report a fatal immune-mediated adverse events’ storm in a thymoma patient treated with Pembrolizumab, leading to hepatotoxicity accompanied by lymphocytosis, thrombocytopenia, and thyroid dysfunction, unveiling a novel potential pathophysiological effect of immunotherapy. The clinical proficiency of the immune checkpoint inhibitors in thymoma patients warrants timely prevention and management of off-target consequences in order to optimize this promising therapeutic option. This case report describes a unique consequence of irAEs, emerging as a red flag warranting a multidisciplinary approach

Correction: Biodegradable nanoparticles bearing amine groups as a strategy to alter surface features, biological identity and accumulation in a lung metastasis model

Correction for 'Biodegradable nanoparticles bearing amine groups as a strategy to alter surface features, biological identity and accumulation in a lung metastasis model' by Diletta Esposito et al., J. Mater. Chem. B, 2018, 6, 5922–5930

Exploratory analysis of potential zones for differential management in precision agriculture through soil-plant-climate patterns

Crop site-specific management, also known as precision farming, is related to the application of information technology to the agricultural systems. The implementation of precision farming programs depends on the integration of soil, plant and climate data in order to generate useful information. The recognition of patterns for soil and plant properties is important especially for crop zone management strategies. Aiming to study management aspects by zone delineation and spatial yield patterns, a field experiment was carried out in Angatuba, SP (23º33 S; 48º18 W; 670 m). Grid soil sampling was performed and plant and climatic data were collected in a 40 ha area cultivated with maize autumn sowing, in two consecutive growing seasons. Integration of these data was done under a procedure for soil pattern recognition, aiming a management by zone delineation and yield spatial distribution verification. The proposed integrated procedures for area segmentation showed to be promising and the management by zone delineation process suggests itself to be influenced by mean properties and climatic conditions.A agricultura de precisão contempla a aplicação da informação tecnológica aos processos produtivos. A implementação de programas nesta linha depende da integração de dados de solo, planta e clima, para a geração de informações úteis. O reconhecimento de padrões em propriedades de solo e planta, é fundamental para a viabilização de práticas nessa área, principalmente para uma abordagem de lavouras por zonas ou classes de manejo. Visando estudar aspectos do delineamento de zonas potenciais para manejo diferenciado e distribuição espacial do potencial produtivo, conduziu-se um experimento na região de Angatuba, SP, Brasil. Uma amostragem intensiva de variáveis de solo e planta, além de dados do microclima, foi realizada em uma área de 40 ha cultivados com milho-sequeiro, em duas safras seguidas, além da integração dessas informações para o reconhecimento de padrões de solo e definição de zonas potenciais de manejo. Também se fez a verificação conjunta com os padrões de distribuição da malha de produtividade, durante duas estações de crescimento de milho-sequeiro. O processo de segmentação utilizado mostrou-se adequado para o delineamento proposto, ao mesmo tempo em que foi observado que a definição de zonas com potencial para manejo diferenciado é um processo dinâmico, podendo ser influenciado por propriedades do meio e condições climáticas.46346

Ile587Val Polymorphism of the eIF2B5 Gene as Susceptibility Factor for Multiple Sclerosis

ABSTRAC

Dark sectors 2016 Workshop: community report

This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years

Sistema de controle interno da administração pública na União Europeia e no Brasil

- Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.- Localização na estante: 351.9(81+4) S622

The rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance

The SARS-CoV-2 Omicron variant emerged in South Africa in November 2021, and has later been identified worldwide, raising serious concerns. A real-time RT-PCR assay was designed for the rapid screening of the Omicron variant, targeting characteristic mutations of the spike gene. The assay was used to test 737 sewage samples collected throughout Italy (19/21 Regions) between 11 November and 25 December 2021, with the aim of assessing the spread of the Omicron variant in the country. Positive samples were also tested with a real-time RT-PCR developed by the European Commission, Joint Research Centre (JRC), and through nested RT-PCR followed by Sanger sequencing. Overall, 115 samples tested positive for Omicron SARS-CoV-2 variant. The first occurrence was detected on 7 December, in Veneto, North Italy. Later on, the variant spread extremely fast in three weeks, with prevalence of positive wastewater samples rising from 1.0% (1/104 samples) in the week 5–11 December, to 17.5% (25/143 samples) in the week 12–18, to 65.9% (89/135 samples) in the week 19–25, in line with the increase in cases of infection with the Omicron variant observed during December in Italy. Similarly, the number of Regions/Autonomous Provinces in which the variant was detected increased fromone in the first week, to 11 in the second, and to 17 in the last one. The presence of the Omicron variant was confirmed by the JRC real-time RT-PCR in 79.1% (91/115) of the positive samples, and by Sanger sequencing in 66% (64/97) of PCR amplicons