Multiplate focusing collimator

An appartus is described for scanning relatively small near sources of penetrating radiation to obtain the energy distribution thereof, wherein a collimator assembly is interposed between a radiation source and a radiation detector. The collimator assembly has a plurality of plates aligned in parallel planes with respect to a common axis normal to their centers. All the plates have similar random distribution of apertures. All apertures on each plate are the same size. The size of respective plates, the size of the apertures of said respective plates, and the spacing between said respective plates vary precisely according to a predetermined ratio to produce radiation channels which converge to a focal point. The radiation incident to the radiation detector is maximized when the focal point and the radiation source are co-incident

Neutralino-hadron scattering in the NMSSM

We provide a scan of the parameter space for neutralino-hadron scattering in the next-to-minimal supersymmetric standard model using an updated value for the strange quark sigma commutator. These results also take into account constraints from WMAP data on the relic density and new constraints from the Large Hadron Collider. We find that the resultant spin-independent cross sections are smaller in magnitude than those found in recent results obtained within the constrained minimal supersymmetric standard model, yet still great enough to feasibly allow for detection in the case of bino-like neutralinos.Comment: 4 pages 5 figure

Observing the Geometry of Warped Compactification via Cosmic Inflation

Using DBI inflation as an example, we demonstrate that the detailed geometry of warped compactification can leave an imprint on the cosmic microwave background (CMB). We compute CMB observables for DBI inflation in a generic class of warped throats and find that the results (such as the sign of the tilt of the scalar perturbations and its running) depend sensitively on the precise shape of the warp factor. In particular, we analyze the warped deformed conifold and find that the results can differ from those of other warped geometries, even when these geometries approximate well the exact metric of the warped deformed conifold.Comment: 4 pages, 3 figures. v2: References and clarifications adde

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients

Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of prognostic significance. Methods: Immunohistochemistry for AR, AR phosphorylated at Ser-81 (pARS81), AR phosphorylated at Ser-578 (pARS578), PKC and phosphorylated PKC (pPKC) was performed on 90 hormone-naïve prostate cancer specimens. Protein expression was quantified using the weighted histoscore method and examined with regard to clinico-pathological factors and outcome measures; time to biochemical relapse, survival from biochemical relapse and disease-specific survival. Results: Nuclear PKC expression strongly correlated with nuclear pARS578 (c.c. 0.469, p=0.001) and cytoplasmic pARS578 (c.c. 0.426 p=0.002). High cytoplasmic and nuclear pARS578 were associated with disease-specific survival (p<0.001 and p=0.036 respectively). High nuclear PKC was associated with lower disease-specific survival when combined with high pARS578 in the cytoplasm (p=0.001) and nucleus (p=0.038). Combined high total pARS81 and total pARS578 was associated with decreased disease-specific survival (p=0.005) Conclusions: pARS578 expression is associated with poor outcome and is a potential independent prognostic marker in hormone-naïve prostate cancer. Furthermore, PKC driven AR phosphorylation may promote prostate cancer progression and provide a novel therapeutic target

Film calibration for the Skylab/ATM S-056 X-ray telescope

The sensitometry and film calibration effort for the Skylab/ATM S-056 X-ray telescope is summarized. The apparatus and procedures used are described together with the two types of flight film used, Kodak SO-212 and SO-242. The sensitometry and processing of the flight film are discussed, and the results are presented in the form of the characteristic curves and related data. The use of copy films is also discussed

The impact of broadband in schools

The report reviews evidence for the impact of broadband in English schools, exploring; Variations in provision in level of broadband connectivity; Links between the level of broadband activity and nationally accessible performance data; Aspects of broadband connectivity and the school environment that contribute to better outcomes for pupils and teachers; Academic and motivational benefits associated with educational uses of this technology

The Effects of Punishment in Serial Verbal Learning

This investigation was concerned with two major problems: (a) the effect of punishment for error on the rate of serial verbal learning and on the amount of retroactive and proactive inhibition in the recall and relearning of the serial verbal habit, and (b) the determination of the direction and extent of muscular tension accompanying these learning and relearning conditions