Study on outcome of N-acetylcysteine in rodenticide poisoning cases in a rural tertiary care teaching hospital

Background: Rodenticide is one of the pesticides and heterogeneous substances used to kill rats. Rodenticide poisoning is the major health problem in Asian countries, particularly mode of self-poisoning, prevalent in India. It causes hepatotoxicity and no antidote has been found. N-acetylcysteine (NAC) is a powerful antioxidant and used in the treatment of acetaminophen-induced hepatotoxicity.  The aim of the study is to find the outcome of use of NAC in rodenticide poisoning.  The main objectives of this study were to determine the role of NAC in liver impairment rodenticide poisoning patients.   Methods: A record based observational study was conducted for the period of 3 months from August 2019 to October 2019 at Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu. Data were collected according to the proforma designed and results were analyzed using standard methods.Results: Out of 50 patients, 21 (42%) were males and 29 (58%) were females. Age group between 21-30 years contributes the highest 20 (40%). Majority of type of rodenticide compound consumed by patients were paste 29 (58%) and less than four hours 34 (68%) patients were admitted. Patients with abnormal liver functions were tested, serum glutamic oxaloacetic transaminase/ aspartate aminotransferase -12 patients, 7 treated with NAC. serum glutamic pyruvic transaminase/ alanine aminotransferase - 9 patients, 2 treated with NAC. 37 (74%) were recovered out of 50 (100%), among them 28 (56%) treated with NAC.Conclusions: In liver impairment rodenticide poisoning patients, early use of NAC shows a significant result and the rate of recovery is also high

Ethyl 1-benzene­sulfonyl-2-[(E)-2-(2-methyl­phen­yl)ethen­yl]indole-3-carboxyl­ate

In the title compound, C26H23NO4S, the phenyl, tolyl and ester groups make dihedral angles of 82.28 (5), 77.67 (6) and 8.52 (6)°, respectively, with the indole ring system. The S atom of the sulfonyl group is displaced by 0.1968 (4) Å from the indole mean plane. The mol­ecular structure is stabilized by weak intra­molecular C—H⋯O inter­actions. The crystal structure structure features short intramolecular C—H⋯O contacts and π–π stacking inter­actions between the phenyl and tolyl groups [centroid–centroid distance = 3.9448 (11) Å]

Physico-Chemical and Bacteriological Characteristics of Noyyal River and Ground Water Quality of Perur, India

The study was conducted to findout the physico-chemical and bacteriological characteristics of Noyyal River and ground water quality of Perur, India. The river water and ground water (bore well and open well) samples were collected in and around Perur and analyzed for various physico-chemical and bacteriological parameters. The study indicated that the mean value of studied parameters, except phosphate, biological oxygen demand (BOD), chemical oxygen demand (COD) of the river water and ground water samples were within the permissible limit. The parameters include total suspended solids (TSS-132.2 mgl-1), BOD (9.55 mgl-1), COD (19.28 mgl-1), phosphate (PO42--1.58 mgl-1) and total nitrogen (TN-2.04 mgl-1) of the river water sample were found higher when compared to the ground water samples. The bacteriological study showed that the total heterotrphic bacteria (THB -124.4 x 103 CFU/ml), Total Coliforms (TC-2600 MPN/10ml), Faecal Coliforms (FC-1750 MPN/10ml), Faecal Streptococci (FS-120 MPN/10ml) and FC/FS ratio (14.6) in the river water samples were found to be greater than the standard WHO limits. The generic distribution in the samples revealed that the presence of Escherichia coli , Staphylococcus, Enterobacter, Streptococci, Bacillus and Micrococcus were predominant in river water samples. The river water was found to be unfit for human consumption due to the exceeding level of Coliforms. The quality of ground water around Noyyal River was found to be safe and utilizable for cultivation purposes. If the quality management is properly maintained, the river water could be utilized for a wide range of application viz, irrigation, drinking etc. @ JASE

1,3-Dimethyl­benzo[b]dibenzothio­phene

The molecule of the title compound, C18H14S, is approximately planar (r.m.s. deviation = 0.029 Å). The crystal packing is stabilized by weak inter­molecular C—H⋯π inter­actions

Discovery of selective and potent anti-tubercular activity in arylpentane-1,4-diones

411-415Anti-tubercular activity (MIC 50μg/mL against Mtb H37Rv) have been reported in hispolons, which possess α, β-unsaturated-1,3-diketone functional group. In the pursuit to optimize structure and bioactivity, various substituted arylpentane-1,4-diones S1-8 have been synthesised. Upon screening, the test compounds show negligible antimicrobial activity against the tested organisms at 100 μg/mL but show antitubercular activity against Mycobacterium tuberculosis H37Rv strain with an MIC 0.8 to 25μg/mL. Compounds having a halogen at the ortho position on the aromatic ring show highest potency (MIC 0.8μg/mL), implying a relation between the position of the halogen atom and anti-tubercular activity

2-Methyl-1-phenyl­sulfonyl-1H-indole-3-carbaldehyde

In the title compound, C16H13NO3S, the sulfonyl-bound phenyl ring forms a dihedral angle of 84.17 (6)° with the indole ring system. An intra­molecular C—H⋯O hydrogen bond generates an S(6) ring motif. The crystal structure exhibits weak inter­molecular C—H⋯O hydrogen bonds and π–π inter­actions between the five- and six-membered rings of the indole group [centroid–centroid distance = 3.6871 (9) Å]

Investigation of 2-oxopyrrolidine 5-carboxylic acid amides derivatives as potential anti-tubercular agents based on the similarity screening results from molecular fingerprints and swiss similarity

Many open source in silico tools are available for drug discovery, this paper attempts to correlate the results obtained from two such tools with results obtained from in vitro screening. Discovery of novel Anti-TB agents became a necessity due to the ever increasing problem of drug resistance. As heterocyclic compounds are known to possess potent biological activity, here an attempt has been made to synthesize pyrazolidine derivatives from pyroglutamic acid. Further the synthesized derivatives are analyzed by IR, NMR and Mass spectral studies and screened for anti-tubercular and antimicrobial activity

3-Iodo-2-methyl-1-phenyl­sulfonyl-1H-indole

In the title compound, C15H12INO2S, the sulfonyl-bound phenyl ring forms a dihedral angle 82.84 (9)° with the indole ring system. The mol­ecular structure is stabilized by a weak intra­molecular C—H⋯O hydrogen bond. The crystal structure exhibits weak inter­molecular C—H⋯π inter­actions and π–π inter­actions between the indole groups [centroid–centroid distance between the five-membered and six-membered rings of the indole group = 3.7617 (18) Å]