Conical Emission in Heavy Ion Collisions

A broadened or double humped away-side structure was observed in 2-particle azimuthal jet-like correlations at RHIC and SPS. This modification can be explained by conical emission, from either Mach-cone shock waves or Cherenkov gluon radiation, and by other physics mechanisms, such as large angle gluon radiation, jets deflected by radial flow and path-length dependent energy loss. Three-particle jet-like correlations are studied for their power to distinguish conical emission from other mechanisms. This article discusses Mach-cone shock waves, Cherenkov gluon radiation and the experimental evidence for conical emission from RHIC and SPS.Comment: Talk given at QM2008, Jaipur, India. 8 pages, 7 figure

Understanding jet quenching and medium response with di-hadron correlation

A brief review of the $p_T$ dependence of the dihadron correlations from RHIC is presented. We attempt to construct a consistent picture that can describe the data as a whole, focusing on the following important aspects, 1) the relation between jet fragmentation of survived jet and medium response to quenched jets, 2) the possible origin of the medium response and its relation to intermediate $p_T$ physics for single hadron production, 3) the connection between the near-side ridge and away-side cone, 4) and their relations to low energy results.Comment: 8 pages, 8 figures, presented at the 20th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions, "Quark Matter 2008", Jaipur, India, February 4-10, 2008. Updated with the published versio

Development of relativistic shock waves in viscous gluon matter

To investigate the formation and the propagation of relativistic shock waves in viscous gluon matter we solve the relativistic Riemann problem using a microscopic parton cascade. We demonstrate the transition from ideal to viscous shock waves by varying the shear viscosity to entropy density ratio $\eta/s$. We show that an $\eta/s$ ratio larger than 0.2 prevents the development of well-defined shock waves on time scales typical for ultrarelativistic heavy-ion collisions. These findings are confirmed by viscous hydrodynamic calculations.Comment: 4 pages, 3 figures - To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse

ϕ\phi meson production and partonic collectivity at RHIC

New results on $\phi$-meson production and elliptic flow $v_{2}$ measurements from RHIC 2004 run (Run-IV) have been reviewed. In addition, the di-hadron correlation function between the trigged $\phi$ and $\Omega$ and the associated soft particles was simulated. Knowledge about these results are discussed.Comment: 8 pages, 7 figures; Invited talk in International Conference on Strangess in Quark Matter (SQM2006), UCLA, California, USA, March 26-31, 2006; to be publsihed in the Proceeding isuue of J. Phys.

Shock waves in strongly coupled plasmas

Shock waves are supersonic disturbances propagating in a fluid and giving rise to dissipation and drag. Weak shocks, i.e., those of small amplitude, can be well described within the hydrodynamic approximation. On the other hand, strong shocks are discontinuous within hydrodynamics and therefore probe the microscopics of the theory. In this paper we consider the case of the strongly coupled N=4 plasma whose microscopic description, applicable for scales smaller than the inverse temperature, is given in terms of gravity in an asymptotically $AdS_5$ space. In the gravity approximation, weak and strong shocks should be described by smooth metrics with no discontinuities. For weak shocks we find the dual metric in a derivative expansion and for strong shocks we use linearized gravity to find the exponential tail that determines the width of the shock. In particular we find that, when the velocity of the fluid relative to the shock approaches the speed of light $v\to 1$ the penetration depth $\ell$ scales as $\ell\sim (1-v^2)^{1/4}$. We compare the results with second order hydrodynamics and the Israel-Stewart approximation. Although they all agree in the hydrodynamic regime of weak shocks, we show that there is not even qualitative agreement for strong shocks. For the gravity side, the existence of shock waves implies that there are disturbances of constant shape propagating on the horizon of the dual black holes.Comment: 47 pages, 8 figures; v2:typos corrected, references adde

Rational Design of Pathogen-Mimicking Amphiphilic Materials as Nanoadjuvants

An opportunity exists today for cross-cutting research utilizing advances in materials science, immunology, microbial pathogenesis, and computational analysis to effectively design the next generation of adjuvants and vaccines. This study integrates these advances into a bottom-up approach for the molecular design of nanoadjuvants capable of mimicking the immune response induced by a natural infection but without the toxic side effects. Biodegradable amphiphilic polyanhydrides possess the unique ability to mimic pathogens and pathogen associated molecular patterns with respect to persisting within and activating immune cells, respectively. The molecular properties responsible for the pathogen-mimicking abilities of these materials have been identified. The value of using polyanhydride nanovaccines was demonstrated by the induction of long-lived protection against a lethal challenge of Yersinia pestis following a single administration ten months earlier. This approach has the tantalizing potential to catalyze the development of next generation vaccines against diseases caused by emerging and re-emerging pathogens

Rational Design of Pathogen-Mimicking Amphiphilic Materials as Nanoadjuvants

An opportunity exists today for cross-cutting research utilizing advances in materials science, immunology, microbial pathogenesis, and computational analysis to effectively design the next generation of adjuvants and vaccines. This study integrates these advances into a bottom-up approach for the molecular design of nanoadjuvants capable of mimicking the immune response induced by a natural infection but without the toxic side effects. Biodegradable amphiphilic polyanhydrides possess the unique ability to mimic pathogens and pathogen associated molecular patterns with respect to persisting within and activating immune cells, respectively. The molecular properties responsible for the pathogen-mimicking abilities of these materials have been identified. The value of using polyanhydride nanovaccines was demonstrated by the induction of long-lived protection against a lethal challenge of Yersinia pestis following a single administration ten months earlier. This approach has the tantalizing potential to catalyze the development of next generation vaccines against diseases caused by emerging and re-emerging pathogens

Design of a Protective Single-Dose Intranasal Nanoparticle-Based Vaccine Platform for Respiratory Infectious Diseases

Despite the successes provided by vaccination, many challenges still exist with respect to controlling new and re-emerging infectious diseases. Innovative vaccine platforms composed of adaptable adjuvants able to appropriately modulate immune responses, induce long-lived immunity in a single dose, and deliver immunogens in a safe and stable manner via multiple routes of administration are needed. This work describes the development of a novel biodegradable polyanhydride nanoparticle-based vaccine platform administered as a single intranasal dose that induced long-lived protective immunity against respiratory disease caused by Yesinia pestis, the causative agent of pneumonic plague. Relative to the responses induced by the recombinant protein F1-V alone and MPLA-adjuvanted F1-V, the nanoparticle-based vaccination regimen induced an immune response that was characterized by high titer and high avidity IgG1 anti-F1-V antibody that persisted for at least 23 weeks post-vaccination. After challenge, no Y. pestis were recovered from the lungs, livers, or spleens of mice vaccinated with the nanoparticle-based formulation and histopathological appearance of lung, liver, and splenic tissues from these mice post-vaccination was remarkably similar to uninfected control mice

Transverse-momentum dependent modification of dynamic texture in central Au+Au collisions at sqrt(S_NN)=200 GeV

Correlations in the hadron distributions produced in relativistic Au+Au collisions are studied in the discrete wavelet expansion method. The analysis is performed in the space of pseudorapidity (|eta| < 1) and azimuth (full 2 pi) in bins of transverse momentum (p_t) from 0.14 < p_t < 2.1 GeV/c. In peripheral Au+Au collisions a correlation structure ascribed to mini-jet fragmentation is observed. It evolves with collision centrality and p_t in a way not seen before which suggests strong dissipation of minijet fragmentation in the longitudinally-expanding medium.Comment: 6 pages, 3 figure, accepted as Phys.Rev.C Rapid Communication. This version fixes journal style issue

Pion interferometry in Au+Au collisions at sqrt[sNN]=200GeV

We present a systematic analysis of two-pion interferometry in Au+Au collisions at sqrt[sNN]=200GeV using the STAR detector at Relativistic Heavy Ion Collider. We extract the Hanbury-Brown and Twiss radii and study their multiplicity, transverse momentum, and azimuthal angle dependence. The Gaussianness of the correlation function is studied. Estimates of the geometrical and dynamical structure of the freeze-out source are extracted by fits with blast-wave parametrizations. The expansion of the source and its relation with the initial energy density distribution is studied