Evaluating unspecific oxidative stress parameters in the sera of patients with irritable bowel syndrome

Objective: Irritable bowel syndrome (IBS) is a common global condition characterized by abdominal pain and alterations in bowel habits not caused by other organic diseases and its etiopathogenesis has not been elucidated. In this study, we aimed to evaluate the oxidative stress parameters in patients with IBS. Materials and methods: Fifty patients diagnosed with IBS using the Rome III criteria and a control group of 50 healthy subjects were included in the study. Oxidative stress parameters including total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values were analyzed from all study subjects. Results: Compared to the controls; the TOS and OSI values were significantly higher, and the TAS value was significantly lower in IBS patients (p < 0.001 for all). Conclusions: In present study we demonstrated that oxidative stress increased and antioxidant capacity decreased in IBS, and antioxidants might be beneficial in the supportive treatment for IBS

Evaluación de parámetros de estrés oxidativo y actividades metabólicas de enfermeras trabajando en turnos diurnos y nocturnos

Se objetivó evaluar estrés oxidativo y actividades metabólicas de enfermeras en turnos diurnos y nocturnos. Participaron enfermeras de Unidad de Terapia Intensiva (UTI, n=70) y del servicio común (SC, n=70). Se obtuvieron muestras sanguíneas al inicio y al final de los turnos para medir parámetros de estrés oxidativo. Las actividades metabólicas también fueron analizadas utilizando brazaletes SenseWear. Los parámetros de estrés oxidativo aumentaron hacia el final de los turnos de todas las enfermeras SC y UTI, comparados con la medida de inicio. Los niveles de TAS, TOS y OSI no eran significativamente diferentes entre enfermeras SC y UTI al cierre de los turnos diurnos y nocturnos. Las actividades metabólicas de enfermeras SC y UTI se mostraron similares. Consecuentemente, los parámetros de estrés oxidativo y las actividades metabólicas de enfermeras SC y UTI no resultaron diferentes, y todas las enfermeras sufren efectos semejantes en sus turnos, tanto diurnos como nocturnos.O objetivo deste estudo foi avaliar o estresse oxidativo e as atividades metabólicas das enfermeiras em turnos diurnos e noturnos. Enfermeiras da Unidade de Tratamento Intensivo (UTI) (n=70) e do serviço comum (SC) (n=70) participaram do estudo. Logo no início e ao final dos turnos, amostras de sangue foram obtidas para medir parâmetros de estresse oxidativo. Atividades metabólicas também foram analisadas com o uso da braçadeira SenseWear. Parâmetros de estresse oxidativo aumentaram no fim dos turnos de todas as enfermeiras SC e UTI quando comparados ao início dos turnos. Comparados às enfermeiras SC, os níveis de TAS, TOS e OSI das enfermeiras de UTI não eram significativamente diferentes no final dos turnos diurnos e noturnos. Além disso, as atividades metabólicas das enfermeiras de SC e UTI se revelaram como sendo similares. Assim, os parâmetros de estresse oxidativo e as atividades metabólicas das enfermeiras SC e UTI não eram diferentes, e todas as enfermeiras sofrem efeitos semelhantes dos turnos, tanto no dia quanto na noite.The aim of this study was to evaluate the oxidative stress and metabolic activities of nurses working day and night shifts. Intensive care unit (ICU) (n=70) and ordinary service (OS) nurses (n=70) were enrolled in the study. Just before and the end of the shifts, blood samples were obtained to measure the participants' oxidative stress parameters. Metabolic activities were analyzed using the SenseWear Armband. Oxidative stress parameters were increased at the end of the shifts for all OS and ICU nurses compared to the beginning of the shifts. Compared to the OS nurses, the ICU nurses' TAS, TOS, and OSI levels were not significantly different at the end of the day and night shifts. The metabolic activities of the OS and ICU nurses were found to be similar. As a result, the OS and ICU nurses' oxidative stress parameters and metabolic activities were not different, and all of the nurses experienced similar effects from both the day and night shifts

Evaluation of the safety of intracameral trypan blue injection on corneal tissue using oxidative stress parameters and apoptotic activity: an experimental study

Purpose: The present experimental study aimed to investigate the effects of intracameral trypan blue (TB) on oxidative stress parameters and apoptosis in corneal tissue. Methods: Thirty rats were randomly assigned to three groups of 10 rats each: the sham group (Group 1); control group (Group 2); and treatment group (Group 3). The control group was administered 0.01 cc of balanced salt solution. The treatment group was administered 0.006 mg/0.01 cc of TB. The total antioxidant status (TAS) and total oxidant status (TOS) in corneal tissue and blood were measured and the oxidative stress index (OSI) was calculated. Finally, corneal tissue histopathology was evaluated using staining for caspase-3 and -8, and apoptotic activity was examined. Results: The TAS, TOS and OSI levels in the blood samples were not significantly different (p>0.05 for all). Compared with the sham and control groups, the TOS and OSI levels in corneal tissue were significantly different in the treatment group (p<0.05 for all). No significant difference was observed between the sham group and the control group (p>0.05). Immunohistochemical staining for caspase-3 and caspase-8 demonstrated higher apoptotic activity in the TB group than in the sham and control groups. Conclusion: The present study showed that intracameral TB injection is safe systematically but may be toxic to corneal tissue, as demonstrated using oxidative stress parameters and histopathological evaluation

What is the fittest criterion for giving chemotherapy for an elderly patient diagnosed with follicular lymphoma?

An 85-year-old British man admitted to our department in July 2018 with enlarged lumps in cervical, axillary and inguinal sites. He was diagnosed with Follicular lymphoma (Stage 3 Grade 3A). In his past history, September 2017, he had undergone percutaneous coronary stent intervention to the left anterior descending coronary artery. Treatment for lymphoma was needed due to the high tumor burden. </p

Comparative effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease: a prospective randomized trial

Aim: The aim of this study was to compare the effectiveness of diet alone and diet plus metformin treatment on omentin levels in type 2 diabetes patients with nonalcoholic fatty liver disease. Methods: Consecutively 88 patients who had hepatic steatosis with type-2 DM were recruited for the study. For randomization, 28 patients who had exclusion criteria were excluded from the study. The remaining patients (n = 60) were randomized into two groups. Only diet therapy were given to Group 1(n = 30) and metformin 2 gram/day plus diet were given to group 2 (n = 30) during 3 months. During the follow-up period 5 patients in group 1 and 1 patient in group 2 did not come for follow-up. Therefore we evaluated 25 patients in group 1 and 29 patients in group 2. Omentin levels were analyzed at admission and at the end of the study.Results: There was a statistically significant difference in the values of body weight, body mass index, waist and hip circumference, body fat percentage (%), and omentin in group 1; and in the values of body weight, BMI, waist and hip circumference, body fat percentage (%), and omentin in group 2. Omentin levels were significantly decreased with the treatment in both groups (5.37 ± 1.31 ng/ml to 4.00 ± 1.46 ng/ml in group 1; 6.96 ± 2.10 ng/ml to 3.92 ± 0.89 ng/ml in group 2, p = 0.001 respectively). When compared the percentage of changes between two groups, it was found that the omentin value was more decreased in group 2 (p = 0.032).Conclusions: Although diet and diet plus metformin treatment decreased the omentin levels, diet plus metformin treatment would be more beneficial in type 2 diabetes patients with nonalcoholic fatty liver disease.<p