Estrategia del storytelling y el proceso de ventas en la cartera de clientes de RPP noticias Cusco, 2019

La presente investigación tuvo como objetivo general determinar el grado de relación de la estrategia del Storytelling y proceso de ventas en la cartera de clientes de RPP Noticias Cusco, 2019. En cuanto a la metodología el alcance de la investigación fue correlacional, de enfoque cuantitativo y diseño de carácter no experimental, la población y muestra fue de 70 clientes de la cartera de clientes de RPP Noticias Cusco, 2019. La técnica utilizada fue le encuesta, la cual fue aplicada con un cuestionario, los datos fueron procesados con el programa SPSS y para probar la hipótesis correlacional se ha utilizado la prueba estadística Chi cuadrado y el coeficiente de correlación de Spearman. Los resultados evidencian que la estrategia del Storytelling de RPP Noticias Cusco, presenta niveles de muy bueno así lo refirieron el 50% de la cartera de clientes de RPP Noticias Cusco, 2019, y el proceso de ventas en la cartera de clientes de RPP Noticias Cusco, 2019 presenta niveles muy adecuados lo cual fue evidenciado en la percepción del 71.4% de clientes; finalmente el Storytelling se relaciona directamente con el proceso de ventas en la cartera de clientes de RPP Noticias Cusco, 2019 ( p = 0.0000 < 0.05, en la prueba Chi – cuadrado), y la correlación de Spearman es del 71.8%.The general objective of this research was to establish the degree of relationship between the Storytelling strategy and the sales process in the customer portfolio of RPP Noticias Cusco, 2019. In terms of methodology, the scope of the research was correlational, quantitative approach and non-experimental design, the population and sample was 70 customers of the customer portfolio of RPP Noticias Cusco, 2019. The technique used was the survey, which was applied with a questionnaire, the data were processed with the SPSS program and to test the correlational hypothesis, the Chi-square statistical test and the Spearman correlation coefficient were used. The results show that the Storytelling strategy of RPP Noticias Cusco, presents levels of very good as reported by 50% of the customer base of RPP Noticias Cusco, 2019, and the sales process in the customer base of RPP Noticias Cusco, 2019 presents very adequate levels which was evidenced in the perception of 71. 4% of customers; finally, Storytelling is directly related to the sales process in the customer portfolio of RPP Noticias Cusco, 2019 (p = 0.0000 < 0.05, in the Chi - square test), and the Spearman correlation is 71.8%

Land Use Implications of Expanding Biofuel Demand

The Renewable Fuel Standard mandates in the Energy Independence and Security Act of 2007 will require 36 billion gallons of ethanol to be produced in 2022. The mandates require that 16 of the 36 billion gallons must be produced from cellulosic feedstocks. The potential land use implications resulting from these mandates were examined using two methods, the POLYSYS model and a general equilibrium model. Results of the POLYSYS analysis indicated that 72.1 million tons of corn stover, 23.5 million tons of wheat straw, and 24.7 million acres would be used to produce 109 million tons of switchgrass in 2025 to meet the mandate. Results of the CGE analysis indicated that 10.9 billion bushels of corn grain, 71 million tons of corn stover, and 56,200 tons of switchgrass is needed to meet the mandate.cellulosic ethanol, corn stover, grain ethanol, renewable fuel standard, switchgrass, Crop Production/Industries, Demand and Price Analysis, Environmental Economics and Policy, Land Economics/Use, Resource /Energy Economics and Policy, Q15, Q42,

Pathogenic implications of dysregulated miRNAs in propionic acidemia related cardiomyopathy

Cardiac alterations (hypertrophic/dilated cardiomyopathy, and rhythm alterations) are one of the major causes of mortality and morbidity in propionic acidemia (PA), caused by the deficiency of the mitochondrial enzyme propionyl-CoA carboxylase (PCC), involved in the catabolism of branched-chain amino acids, cholesterol, and odd-chain fatty acids. Impaired mitochondrial oxidative phosphorylation has been documented in heart biopsies of PA patients, as well as in the hypomorphic Pcca−/−(A138T) mouse model, in the latter correlating with increased oxidative damage and elevated expression of cardiac dysfunction biomarkers atrial and brain natriuretic peptides (ANP and BNP) and beta-myosin heavy chain (β-MHC). Here we characterize the cardiac phenotype in the PA mouse model by histological and echocardiography studies and identify a series of upregulated cardiac-enriched microRNAs (miRNAs) in the PA mouse heart, some of them also altered as circulating miRNAs in PA patients’ plasma samples. In PA mice hearts, we show alterations in signaling pathways regulated by the identified miRNAs, which could be contributing to cardiac remodeling and dysfunction; notably, an activation of the mammalian target of rapamycin (mTOR) pathway and a decrease in autophagy, which are reverted by rapamycin treatment. In vitro studies in HL-1 cardiomyocytes indicate that propionate, the major toxic metabolite accumulating in the disease, triggers the increase in expression levels of miRNAs, BNP, and β-MHC, concomitant with an increase in reactive oxygen species. Our results highlight miRNAs and signaling alterations in the PCC-deficient heart which may contribute to the development of PA-associated cardiomyopathy and provide a basis to identify new targets for therapeutic interventionThis work was supported by Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (grant number SAF2016-76004-R) and by Fundación Isabel Gemio and Fundación La Caixa (LCF/PR/PR16/ 11110018). AFG is funded by the FPI-UAM program, EAB and ARB by the Spanish Ministry of Science, Innovation and Universities (predoctoral fellowships FPU15/02923 and BES-2014-069420, respectively

A rush to judgment? Rapid reporting and dissemination of results and its consequences regarding the use of hydroxychloroquine for COVID-19

Funding Information: Disclosures: Dr. Kim reports personal fees from Exagen Diagnostics and GlaxoSmithKline and grants from the National Institutes of Health and the Rheumatology Research Foundation outside the submitted work. Dr. Sparks reports grants from the National Institute of Allergy and Infectious Diseases Autoimmune Centers of Excellence, National Institutes of Health, during the conduct of the study and personal fees from Bristol-Myers Squibb, Gilead, Inova, Janssen, and Optum outside the submitted work. Dr. Berenbaum reports personal fees from Boehringer, Bone Therapeutics, Expanscience, Galapagos, Gilead, GSK, Merck Sereno, MSD, Nordic, No-vartis, Pfizer, Regulaxis, Roche, Sandoz, Sanofi, Servier, UCB, Peptinov, TRB Chemedica, and 4P Pharma outside the submitted work. Dr. Korsten reports personal fees from GlaxoSmith-Kline, Sanofi-Aventis, Pfizer, AbbVie, Novartis Pharma, Lilly, and Bristol-Myers Squibb outside the submitted work. Dr. Sat-tui reports funding from a Vasculitis Clinical Research Consortium (VCRC)/Vasculitis Foundation Fellowship. The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319). Dr. Ugarte-Gil reports grants from Pfizer and Janssen outside the submitted work. Dr. Grainger reports nonfinancial support from Pfizer Australia and Janssen Australia and personal fees from Pfizer Australia, Cornerstones, Janssen New Zealand, and Novartis outside the submitted work. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at www .acponline.org/authors/icmje/ConflictOfInterestForms.do?ms Num=M20-1223.publishersversio

First-year Results of Broadband Spectroscopy of the Brightest Fermi-GBM Gamma-Ray Bursts

We present here our results of the temporal and spectral analysis of a sample of 52 bright and hard gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM) during its first year of operation (July 2008-July 2009). Our sample was selected from a total of 253 GBM GRBs based on each event peak count rate measured between 0.2 and 40MeV. The final sample comprised 34 long and 18 short GRBs. These numbers show that the GBM sample contains a much larger fraction of short GRBs, than the CGRO/BATSE data set, which we explain as the result of our (different) selection criteria and the improved GBM trigger algorithms, which favor collection of short, bright GRBs over BATSE. A first by-product of our selection methodology is the determination of a detection threshold from the GBM data alone, above which GRBs most likely will be detected in the MeV/GeV range with the Large Area Telescope (LAT) onboard Fermi. This predictor will be very useful for future multiwavelength GRB follow ups with ground and space based observatories. Further we have estimated the burst durations up to 10MeV and for the first time expanded the duration-energy relationship in the GRB light curves to high energies. We confirm that GRB durations decline with energy as a power law with index approximately -0.4, as was found earlier with the BATSE data and we also notice evidence of a possible cutoff or break at higher energies. Finally, we performed time-integrated spectral analysis of all 52 bursts and compared their spectral parameters with those obtained with the larger data sample of the BATSE data. We find that the two parameter data sets are similar and confirm that short GRBs are in general harder than longer ones.Comment: 40 pages, 11 figures, 3 tables, Submitted to Ap

OCTOCAM: A fast multichannel imager and spectrograph for the 10.4m GTC

OCTOCAM is a multi-channel imager and spectrograph that has been proposed for the 10.4m GTC telescope. It will use dichroics to split the incoming light to produce simultaneous observations in 8 different bands, ranging from the ultraviolet to the near-infrared. The imaging mode will have a field of view of 2' x 2' in u, g, r, i, z, J, H and Ks bands, whereas the long-slit spectroscopic mode will cover the complete range from 4,000 to 23,000 {\AA} with a resolution of 700 - 1,700 (depending on the arm and slit width). An additional mode, using an image slicer, will deliver a spectral resolution of over 3,000. As a further feature, it will use state of the art detectors to reach high readout speeds of the order of tens of milliseconds. In this way, OCTOCAM will be occupying a region of the time resolution - spectral resolution - spectral coverage diagram that is not covered by a single instrument in any other observatory, with an exceptional sensitivity.Comment: 11 pages, 10 figures, SPIE 2010 Astronomical Instrumentatio