The Zig Zag Railway New South Wales [picture] /

Title devised by cataloguer from inscriptions.; Condition: Folds.; Inscriptions: "The Zig Zag. 686"--Printed on image lower left; "Kerry Photo. Sydney."--Printed on image lower right.; Part of the collection: Charles Kerry collection of New South Wales views.; Also available online http://nla.gov.au/nla.pic-vn6100794

Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC^min/+ mice.

APC(min/+) mice, carrying a nonsense mutation in the adenomatous polyposis coli (APC) gene, appear as a perfect model to study development or therapy of intestinal neoplasia. We tested whether the flavonoid flavone is able to affect adenoma development in APC(min/+) mice. Tumor sizes were significantly increased by flavone selectively in small intestine. This was associated with reduced cell numbers displaying cleaved caspase-3 and enhanced expression of phosphoglycoprotein (P-gp). However, according to great variability in P-gp expression in all parts of mice intestines, an association between expression of P-gp and inhibition of apoptosis was demonstrated in human Caco-2 colorectal cancer cells

The Boolean Hierarchy of NP-Partitions

We introduce the boolean hierarchy of k-partitions over NP for k ≥ 3 as a generalization of the boolean hierarchy of sets (i.e., 2-partitions) over NP. Whereas the structure of the latter hierarchy is rather simple the structure of the boolean hierarchy of k-partitions over NP for k ≥ 3 turns out to be much more complicated. We establish the Embedding Conjecture which enables us to get a complete idea of this structure. This conjecture is supported by several partial results