529 research outputs found
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Borderline personality disorder (BOR) is determined by environmental and
genetic factors, and characterized by affective instability and impulsivity,
diagnostic symptoms also observed in manic phases of bipolar disorder (BIP).
Up to 20% of BIP patients show comorbidity with BOR. This report describes the
first case–control genome-wide association study (GWAS) of BOR, performed in
one of the largest BOR patient samples worldwide. The focus of our analysis
was (i) to detect genes and gene sets involved in BOR and (ii) to investigate
the genetic overlap with BIP. As there is considerable genetic overlap between
BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of
BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD.
GWAS, gene-based tests and gene-set analyses were performed in 998 BOR
patients and 1545 controls. Linkage disequilibrium score regression was used
to detect the genetic overlap between BOR and these disorders. Single marker
analysis revealed no significant association after correction for multiple
testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 ×
10−7) and PKP4 (P=8.67 × 10−7); and gene-set analysis yielded a significant
finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate).
Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The
most notable finding of the present study was the genetic overlap of BOR with
BIP (rg=0.28 [P=2.99 × 10−3]), SCZ (rg=0.34 [P=4.37 × 10−5]) and MDD (rg=0.57
[P=1.04 × 10−3]). We believe our study is the first to demonstrate that BOR
overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined
to transdiagnostic clinical symptoms should be examined in future studies
MiniBooNE Results and Neutrino Schemes with 2 sterile Neutrinos: Possible Mass Orderings and Observables related to Neutrino Masses
The MiniBooNE and LSND experiments are compatible with each other when two
sterile neutrinos are added to the three active ones. In this case there are
eight possible mass orderings. In two of them both sterile neutrinos are
heavier than the three active ones. In the next two scenarios both sterile
neutrinos are lighter than the three active ones. The remaining four scenarios
have one sterile neutrino heavier and another lighter than the three active
ones. We analyze all scenarios with respect to their predictions for
mass-related observables. These are the sum of neutrino masses as constrained
by cosmological observations, the kinematic mass parameter as measurable in the
KATRIN experiment, and the effective mass governing neutrinoless double beta
decay. It is investigated how these non-oscillation probes can distinguish
between the eight scenarios. Six of the eight possible mass orderings predict
positive signals in the KATRIN and future neutrinoless double beta decay
experiments. We also remark on scenarios with three sterile neutrinos. In
addition we make some comments on the possibility of using decays of high
energy astrophysical neutrinos to discriminate between the mass orderings in
presence of two sterile neutrinos.Comment: 33 pages, 8 figures. Comments added, to appear in JHE
Mechanism Design for Perturbation Stable Combinatorial Auctions
Motivated by recent research on combinatorial markets with endowed valuations
by (Babaioff et al., EC 2018) and (Ezra et al., EC 2020), we introduce a notion
of perturbation stability in Combinatorial Auctions (CAs) and study the extend
to which stability helps in social welfare maximization and mechanism design. A
CA is if the optimal solution is resilient to
inflation, by a factor of , of any bidder's valuation for any
single item. On the positive side, we show how to compute efficiently an
optimal allocation for 2-stable subadditive valuations and that a Walrasian
equilibrium exists for 2-stable submodular valuations. Moreover, we show that a
Parallel 2nd Price Auction (P2A) followed by a demand query for each bidder is
truthful for general subadditive valuations and results in the optimal
allocation for 2-stable submodular valuations. To highlight the challenges
behind optimization and mechanism design for stable CAs, we show that a
Walrasian equilibrium may not exist for -stable XOS valuations for any
, that a polynomial-time approximation scheme does not exist for
-stable submodular valuations, and that any DSIC mechanism that
computes the optimal allocation for stable CAs and does not use demand queries
must use exponentially many value queries. We conclude with analyzing the Price
of Anarchy of P2A and Parallel 1st Price Auctions (P1A) for CAs with stable
submodular and XOS valuations. Our results indicate that the quality of
equilibria of simple non-truthful auctions improves only for -stable
instances with
High Isolation Quad-Element SWB-MIMO Antenna with Dual Band-Notch for ISM and WLAN Band Wireless Applications
A quad-element super-wideband (2-20GHz) MIMO antenna including dual notched-band response at WiMAX (3.30-3.70GHz) and satellite-band (6.99-8.09GHz) is designed on RO3035 with total dimension of 118mm×86mm×1.67mm. Unique decoupling structure has been deployed to enhance the isolation (˃20dB) between two antenna elements. The fundamental properties of MIMO antennas like bandwidth ratio (10:1), isolation (>18dB), gain (4.14dB), Envelop Correlation-Coefficient (<0.0065), Total Active Reflection-Coefficient (< 0dB), Channel Capacity Loss (<0.25bps/Hz) and radiation patterns are also investigated in order to determine their practicality. Measurement and simulation results of the proposed SWB-MIMO antenna from 2 to 20GHz indicate that it will be the suitable candidate for wireless and biomedical applications
High Isolation Quad-Element SWB-MIMO Antenna with Dual Band-Notch for ISM and WLAN Band Wireless Applications
A quad-element super-wideband (2-20GHz) MIMO antenna including dual notched-band response at WiMAX (3.30-3.70GHz) and satellite-band (6.99-8.09GHz) is designed on RO3035 with total dimension of 118mm×86mm×1.67mm. Unique decoupling structure has been deployed to enhance the isolation (˃20dB) between two antenna elements. The fundamental properties of MIMO antennas like bandwidth ratio (10:1), isolation (>18dB), gain (4.14dB), Envelop Correlation-Coefficient (<0.0065), Total Active Reflection-Coefficient (< 0dB), Channel Capacity Loss (<0.25bps/Hz) and radiation patterns are also investigated in order to determine their practicality. Measurement and simulation results of the proposed SWB-MIMO antenna from 2 to 20GHz indicate that it will be the suitable candidate for wireless and biomedical applications
Care Seeking for Neonatal Illness in Low- and Middle-Income Countries: A Systematic Review
Hadley Herbert and colleagues systematically review newborn care-seeking behaviors by caregivers in low- and middle-income countries
Irreversible Aging Dynamics and Generic Phase Behavior of Aqueous Suspensions of Laponite
In this work we study the aging behavior of aqueous suspension of Laponite
having 2.8 weight % concentration using rheological tools. At various salt
concentration all the samples demonstrate orientational order when observed
using crossed polarizers. In rheological experiments we observe inherent
irreversibility in the aging dynamics which forces the system not to rejuvenate
to the same state in the shear melting experiment carried out at a later date
since preparation. The extensive rheological experiments carried out as a
function of time elapsed since preparation demonstrate the self similar trend
in the aging behavior irrespective of the concentration of salt. We observe
that the exploration of the low energy states as a function of aging time is
only kinetically affected by the presence of salt. We estimate that the energy
barrier to attain the low energy states decreases linearly with increase in the
concentration of salt. The observed superposition of all the elapsed time and
the salt concentration dependent data suggests that the aging that occurs in
low salt concentration systems over a very long period is qualitatively similar
to the aging behavior observed in systems with high salt concentration over a
shorter period.Comment: 27 pages, 8 figures. Langmuir, in pres
Characterization of the interactions of a polycationic, amphiphilic, terminally branched oligopeptide with lipid A and lipopolysaccharide from the deep rough mutant of salmonella minnesota
The lipid A and lipopolysaccharide (LPS) binding and neutralizing activities of a synthetic, polycationic, amphiphilic peptide were studied. The branched peptide, designed as a functional analog of polymyxin B, has a six residue hydrophobic sequence, bearing at its N-terminus a penultimate lysine residue whose α- and E-amino groups are coupled to two terminal lysine residues. In fluorescence spectroscopic studies designed to examine relative affinities of binding to the toxin, neutralization of surface charge and fluidization of the acyl domains, the peptide was active, closely resembling the effects of polymyxin B and its nonapeptide derivative; however, the synthetic peptide does not induce phase transitions in LPS aggregates as do polymyxin B and polymyxin B nonapeptide. The peptide was also comparable with polymyxin B in its ability to inhibit LPS-mediated IL-1 and IL-6 release from human peripheral blood mononuclear cells. The synthetic compound is devoid of antibacterial activities and did not induce conductance fluxes in LPS-containing asymmetric planar membranes. These results strengthen the premise that basicity and amphiphilicity are necessary and sufficient physical properties that ascribe endotoxin binding and neutralizing activities, and further suggest that antibacterial/membrane perturbant and LPS neutralizing activities are dissociable, which may be of value in designing LPS-sequestering agents of low toxicity
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