Dynamics of the NGC 4636 Globular Cluster System - An extremely dark matter dominated galaxy?

We present the first dynamical study of the globular cluster system of NGC 4636. This giant elliptical galaxy is claimed to be extremely dark matter dominated, according to X-ray observations. Using the VLT with FORS2/MXU, we obtained velocities for 174 globular clusters. The clusters have projected galactocentric distances in the range 4 to 70 kpc, the overwhelming majority lie within 30 kpc. We find some indication for a rotation of the red (metal-rich) clusters about the minor axis. Out to a radius of 30 kpc, we find a roughly constant projected velocity dispersion for the blue clusters of ~200 km/s. The red clusters exhibit a distinctly different behavior: at a radius of about 13 kpc, the velocity dispersion drops by ~50 km/s to about 170 km/s which then remains constant out to a radius of 30 kpc. Using only the blue clusters as dynamical tracers, we perform Jeans-analyses for different assumptions of the orbital anisotropy. Depending on the anisotropy and the adopted M/L-values, we find that the dark matter fraction within one effective radius can vary between 20% and 50% with most a probable range between 20% and 30%. A main source of uncertainty is the ambiguity of the velocity dispersion in the outermost bin. Although the dark halo mass still cannot be strongly constrained, NGC 4636 does not seem to be extremely dark matter dominated. The derived circular velocities are also consistent with Modified Newtonian Dynamics.Comment: 19 pages, 18 figures. Accepted for publication in A&A. Appendix A (velocity tables) will be published in the online version of the journa

Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers

Orally administered recombinant Salmonella vaccines represent an attractive option for mass vaccination programmes against various infectious diseases. Therefore, it is crucial to gather knowledge about the possible impact of preexisiting immunity to carrier antigens on the immunogenicity of recombinant vaccines. Thirteen volunteers were preimmunized with Salmonella typhi Ty21a in order to evaluate the effects of prior immunization with the carrier strain. Then, they received three doses of 1-2 x 10(10) viable organisms of either the vaccine strain S. typhi Ty21a (pDB1) expressing subunits A and B of recombinant Helicobacter pylori urease (n = 9), or placebo strain S. typhi Ty21a (n = 4). Four volunteers were preimmunized and boosted with the vaccine strain S. typhi Ty21a (pDB1). No serious adverse effects were observed in any of the volunteers. Whereas none of the volunteers primed and boosted with the vaccine strain responded to the recombinant antigen, five of the nine volunteers preimmunized with the carrier strain showed cellular immune responses to H. pylori urease (56%). This supports the results of a previous study in non-preimmunized volunteers where 56% (five of nine) of the volunteers showed a cellular immune response to urease after immunisation with S. typhi Ty21a (pDB1)