Cross-sectional study of the burden of vector-borne and soil-transmitted polyparasitism in rural communities of Coast Province, Kenya.

BACKGROUND: In coastal Kenya, infection of human populations by a variety of parasites often results in co-infection or poly-parasitism. These parasitic infections, separately and in conjunction, are a major cause of chronic clinical and sub-clinical human disease and exert a long-term toll on economic welfare of affected populations. Risk factors for these infections are often shared and overlap in space, resulting in interrelated patterns of transmission that need to be considered at different spatial scales. Integration of novel quantitative tools and qualitative approaches is needed to analyze transmission dynamics and design effective interventions. METHODOLOGY: Our study was focused on detecting spatial and demographic patterns of single- and co-infection in six villages in coastal Kenya. Individual and household level data were acquired using cross-sectional, socio-economic, and entomological surveys. Generalized additive models (GAMs and GAMMs) were applied to determine risk factors for infection and co-infections. Spatial analysis techniques were used to detect local clusters of single and multiple infections. PRINCIPAL FINDINGS: Of the 5,713 tested individuals, more than 50% were infected with at least one parasite and nearly 20% showed co-infections. Infections with Schistosoma haematobium (26.0%) and hookworm (21.4%) were most common, as was co-infection by both (6.3%). Single and co-infections shared similar environmental and socio-demographic risk factors. The prevalence of single and multiple infections was heterogeneous among and within communities. Clusters of single and co-infections were detected in each village, often spatially overlapped, and were associated with lower SES and household crowding. CONCLUSION: Parasitic infections and co-infections are widespread in coastal Kenya, and their distributions are heterogeneous across landscapes, but inter-related. We highlighted how shared risk factors are associated with high prevalence of single infections and can result in spatial clustering of co-infections. Spatial heterogeneity and synergistic risk factors for polyparasitism need to be considered when designing surveillance and intervention strategies

The minimum period problem in cataclysmic variables

We investigate if consequential angular momentum losses (CAML) or an intrinsic deformation of the donor star in CVs could increase the CV bounce period from the canonical theoretical value ~65 min to the observed value $P_{min} \approx77$ min, and if a variation of these effects in a CV population could wash out the theoretically predicted accumulation of systems near the minimum period (the period spike). We are able to construct suitably mixed CV model populations that a statisticial test cannot rule out as the parent population of the observed CV sample. However, the goodness of fit is never convincing, and always slightly worse than for a simple, flat period distribution. Generally, the goodness of fit is much improved if all CVs are assumed to form at long orbital periods. The weighting suggested by King, Schenker & Hameury (2002) does not constitute an improvment if a realistically shaped input period distribution is used. Put your abstract here.Comment: 10 pages, Latex, 13 postscript figures, Accepted for publication in MNRA

Stories to live by, stories to teach with: a narrative inquiry into preservice teachers' knowledge of teaching literacy from a critical literacy framework with diverse children's literature

This narrative inquiry offers research of literacy and children's literature teaching through inquiry into stories told from the perspective of preservice teachers (PSTs). Through inquiry into PSTs' stories to live by (Connelly and Clandinin, 1999), teacher educators and educational researchers learn about PSTs' experiences with literacy and children's literature and how they work to inform their teaching decisions. The research narratives provide literacy teacher educators with space to consider why and how to (re)design courses taught to PSTs on critical literacy teaching diverse children's literature. Educational researchers learn of ways to further research into PSTs' chosen ways of teaching through study of the research narratives. This inquiry into PSTs' stories follows the research question of: How do preservice teachers' stories to live by inform their orientation towards certain literacy teaching practices of children's literature? It is framed by Connelly and Clandinin's (1999) conceptualization of stories to live by which merges PST participants' personal practical knowledge, lived experience on the professional knowledge landscape, and their identity (i.e., student teacher, future teacher) stories. Analysis of PSTs' stories was done following structural and thematic models and found that PSTs held different views of literacy involving literacy as method and as social practice; they approached teaching literacy following behaviorist, constructivist, and socio-cultural ways; and held conceptualizations of children's literature including as teaching tools, mirrors, diverse, and culturally relevant. Implications for teacher educators include the need for explicit critical literacy teaching diverse children's literature and provision of explicit classroom experiences of teaching diverse children's literature texts. Implications for educational researchers suggest the need for more individual and longitudinal studies of individual PSTs and their stories.Includes bibliographical references

Why Low-Mass Black-Hole Binaries Are Transient

We consider transient behavior in low-mass X-ray binaries. In short-period neutron-star systems (orbital period less than ~ 1d) irradiation of the accretion disk by the central source suppresses this except at very low mass transfer rates. Formation constraints however imply that a significant fraction of these neutron star systems have nuclear-evolved main-sequence secondaries and thus mass transfer rates low enough to be transient. But most short-period low-mass black-hole systems will form with unevolved main-sequence companions and have much higher mass transfer rates. The fact that essentially all of them are nevertheless transient shows that irradiation is weaker, as a direct consequence of the fundamental black-hole property - the lack of a hard stellar surface.Comment: 13 pages (including 3 figures); accepted for publication in Ap

Measuring fitness of Kenyan children with polyparasitic infections using the 20-meter shuttle run test as a morbidity metric.

BACKGROUND: To date, there has been no standardized approach to the assessment of aerobic fitness among children who harbor parasites. In quantifying the disability associated with individual or multiple chronic infections, accurate measures of physical fitness are important metrics. This is because exercise intolerance, as seen with anemia and many other chronic disorders, reflects the body's inability to maintain adequate oxygen supply (VO(2) max) to the motor tissues, which is frequently linked to reduced quality-of-life in terms of physical and job performance. The objective of our study was to examine the associations between polyparasitism, anemia, and reduced fitness in a high risk Kenyan population using novel implementation of the 20-meter shuttle run test (20mSRT), a well-standardized, low-technology physical fitness test. METHODOLOGY/PRINCIPAL FINDINGS: Four villages in coastal Kenya were surveyed during 2009-2010. Children 5-18 years were tested for infection with Schistosoma haematobium (Sh), malaria, filaria, and geohelminth infections by standard methods. After anthropometric and hemoglobin testing, fitness was assessed with the 20 mSRT. The 20 mSRT proved easy to perform, requiring only minimal staff training. Parasitology revealed high prevalence of single and multiple parasitic infections in all villages, with Sh being the most common (25-62%). Anemia prevalence was 45-58%. Using multiply-adjusted linear modeling that accounted for household clustering, decreased aerobic capacity was significantly associated with anemia, stunting, and wasting, with some gender differences. CONCLUSIONS/SIGNIFICANCE: The 20 mSRT, which has excellent correlation with VO(2), is a highly feasible fitness test for low-resource settings. Our results indicate impaired fitness is common in areas endemic for parasites, where, at least in part, low fitness scores are likely to result from anemia and stunting associated with chronic infection. The 20 mSRT should be used as a common metric to quantify physical fitness and compare sub-clinical disability across many different disorders and community settings

Mass estimates in short-period compact binaries

Using stellar models we investigate the relation between mass and the spectral type of the secondary star in low-mass short-period compact binaries such as cataclysmic variables and soft X-ray transients. Allowing for different mass transfer rates and different system ages prior to mass transfer we find that the secondaries should populate a band in the spectral type vs. mass plane. The mass M_ms of a ZAMS star with the same spectral type as the donor is effectively an upper limit to the donor mass. The lower mass limit for a given spectral type depends on the mixing length parameter. If this is large, there is no lower limit if the spectral type is later than K6. The band width decreases from 0.4 M_sun at K6 to less than 0.2 M_sun at K0. If the mixing length parameter is small, there is no lower mass limit if the spectral type is later than M2, and the band width decreases from 0.2 M_sun at M2 to less than 0.1 M_sun for types earlier than K0. We also point out an error in the method suggested by Beekman et al. (1997) to estimate the primary mass in a soft X-ray transient.Comment: Accepted for publication in MNRAS; 6 pages, including 3 figure

Inference of the genetic network regulating lateral root initiation in Arabidopsis thaliana

Regulation of gene expression is crucial for organism growth, and it is one of the challenges in Systems Biology to reconstruct the underlying regulatory biological networks from transcriptomic data. The formation of lateral roots in Arabidopsis thaliana is stimulated by a cascade of regulators of which only the interactions of its initial elements have been identified. Using simulated gene expression data with known network topology, we compare the performance of inference algorithms, based on different approaches, for which ready-to-use software is available. We show that their performance improves with the network size and the inclusion of mutants. We then analyse two sets of genes, whose activity is likely to be relevant to lateral root initiation in Arabidopsis, by integrating sequence analysis with the intersection of the results of the best performing methods on time series and mutants to infer their regulatory network. The methods applied capture known interactions between genes that are candidate regulators at early stages of development. The network inferred from genes significantly expressed during lateral root formation exhibits distinct scale-free, small world and hierarchical properties and the nodes with a high out-degree may warrant further investigation