Modification and Performance Evaluation of Active Solar Dryer for High Moisture Tomato Crop

In this study, two active solar cabinet dryers with capacity each to dry 10 kg of fresh vegetable were fabricated. The drying cabinet of the first dryer was fabricated using plywood and is refer to as unmodified dryer (UM) while the second dryer with white transparent glass and is refer to as modified dryer (MD). The performances of the two dryers in terms of total drying time, final moisture content obtained and preservation of nutritive values of the dried vegetable were investigated using tomato as sample. Ten kilogram of the sample were sliced to about 1cm and neatly arranged in the drying chamber for the drying process in a period of two days (8am-6pm). The results revealed that there was a reduction in total drying time of 2.5 hours, from 18 hours in UM to 15.5hours in MD which corresponds to reduction in moisture content (wet basis) from initial value of 92% to final moisture content of 12- 13.3%. The results further revealed that maximum drying rate of 6.9 kg/h was observed for UM dryer and 9.4 kg/h for MD both obtained within 8 hours of drying time.  The average temperature recorded in the MD was found more than the UM by about 13°C at 3.00pm. The efficiency of the MD in terms of reduction in total drying time was 13.89% higher than the UM. Proximate analysis result shows the composition of the dried tomato in the UM to be protein, 0.76%; lipids, 1.00%; vitamin E, 0.0083%; moisture content, 13.3%; ash, 0.60% and crude fiber, 1.80%. However, the composition of dried tomato in MD were protein, 0.69%; lipids, 0.90%; vitamin E, 0.0080%; moisture content, 12%; ash, 0.58% and crude fiber, 1.78%

Price Transmission, Volatility and Discovery of Gram in Some Selected Markets in Rajathan State, India

Market integration in many agricultural commodities had been extensively studied for the insight it provides into the functioning of such markets, thus giving valuable information about the dynamics of market adjustment, and whether there exist market imperfection, which may justify government intervention. This study empirically investigated price transmission, volatility and discovery of gram across four wholesale gram markets, viz. Jaipur, Kishangarh, Chomu and Malpura in Rajasthan state of India using Johansen's multivariate cointegration approach, VECM, Granger causality tests, GARCH, EGARCH and ARIMA. Monthly wholesale gram price data spanning from January 2011 to December 2015 sourced from AGMARKNET were used. Multivariate cointegration showed that all the selected gram markets were cointegarted in the long-run, meaning long-run price association among these markets. The degree of market integration observed is consistent with the view that Rajasthan state gram markets are quite competitive; thus, provide little justification for extensive and costly government intervention designed to enhance market efficiency through improve competitiveness. Therefore, in order to sustain the present system of market integration, there is need to evolve mechanism that will generate market information and market intelligence which would serve as a platform for guiding farmers in marketing their produce

Assessment of Quality of Out-patient Prescriptions in the National Health Insurance Scheme Unit of a Tertiary Hospital in Nigeria

ABSTRACT The fact that today's evidence based guidelines recommends several drugs in the treatment of a single medical condition make drug treatment particularly challenging. Consequently, many patients use a number of medications a situation referred to as polypharmacy. Polypharmacy is linked to occurrence of health risk through increased drug therapy problems like adverse drug reactions, medication error, adherence problem, economic burden etc. This study characterized the quality of out-patient prescriptions in National Health Insurance Scheme (NHIS) of the University of Maiduguri Teaching Hospital, using some selected indicators of Polypharmacy. These include contraindication, drug interaction, drug for treating side effect of co-prescribed drug and inappropriate dosages. Five Hundred out-patient prescriptions were used for the study. The average number of drug per prescription was 3.95±1.51. About 20.4% of the encounter received prescription with inappropriate combination of five or more drugs. Of this, contraindicated drugs constituted 22.2% of all encounter. There was association between inappropriate prescription and number of drug per prescription (p<0.05). The incidence of inappropriate prescription, potential drug therapy problems, and inappropriate polypharmacy were significantly higher at drug level ≥5 drugs. There is the need to improve on rational prescribing of drugs by retraining of health care providers

Strength of Hydrogen Bond Network Takes Crucial Roles in the Dissociation Process of Inhibitors from the HIV-1 Protease Binding Pocket

To understand the underlying mechanisms of significant differences in dissociation rate constant among different inhibitors for HIV-1 protease, we performed steered molecular dynamics (SMD) simulations to analyze the entire dissociation processes of inhibitors from the binding pocket of protease at atomistic details. We found that the strength of hydrogen bond network between inhibitor and the protease takes crucial roles in the dissociation process. We showed that the hydrogen bond network in the cyclic urea inhibitors AHA001/XK263 is less stable than that of the approved inhibitor ABT538 because of their large differences in the structures of the networks. In the cyclic urea inhibitor bound complex, the hydrogen bonds often distribute at the flap tips and the active site. In contrast, there are additional accessorial hydrogen bonds formed at the lateral sides of the flaps and the active site in the ABT538 bound complex, which take crucial roles in stabilizing the hydrogen bond network. In addition, the water molecule W301 also plays important roles in stabilizing the hydrogen bond network through its flexible movement by acting as a collision buffer and helping the rebinding of hydrogen bonds at the flap tips. Because of its high stability, the hydrogen bond network of ABT538 complex can work together with the hydrophobic clusters to resist the dissociation, resulting in much lower dissociation rate constant than those of cyclic urea inhibitor complexes. This study may provide useful guidelines for design of novel potent inhibitors with optimized interactions

Postnatal Pancreatic Islet β Cell Function and Insulin Sensitivity at Different Stages of Lifetime in Rats Born with Intrauterine Growth Retardation

Epidemiological studies have linked intrauterine growth retardation (IUGR) to the metabolic diseases, consisting of insulin resistance, type 2 diabetes, obesity and coronary artery disease, during adult life. To determine the internal relationship between IUGR and islet β cell function and insulin sensitivity, we established the IUGR model by maternal nutrition restriction during mid- to late-gestation. Glucose tolerance test and insulin tolerance test(ITT) in vivo and glucose stimulated insulin secretion(GSIS) test in vitro were performed at different stages in IUGR and normal groups. Body weight, pancreas weight and pancreas/body weight of IUGR rats were much lower than those in normal group before 3 weeks of age. While the growth of IUGR rats accelerated after 3 weeks, pancreas weight and pancreas/body weight remained lower till 15 weeks of age. In the newborns, the fasting glucose and insulin levels of IUGR rats were both lower than those of controls, whereas glucose levels at 120 and 180 min after glucose load were significantly higher in IUGR group. Between 3 and 15 weeks of age, both the fasting glucose and insulin levels were elevated and the glucose tolerance was impaired with time in IUGR rats. At age 15 weeks, the area under curve of insulin(AUCi) after glucose load in IUGR rats elevated markedly. Meanwhile, the stimulating index of islets in IUGR group during GSIS test at age 15 weeks was significantly lower than that of controls. ITT showed no significant difference in two groups before 7 weeks of age. However, in 15-week-old IUGR rats, there was a markedly blunted glycemic response to insulin load compared with normal group. These findings demonstrate that IUGR rats had both impaired pancreatic development and deteriorated glucose tolerance and insulin sensitivity, which would be the internal causes why they were prone to develop type 2 diabetes

Homology modeling and molecular dynamics simulations of MUC1-9/H-2Kb complex suggest novel binding interactions

International audienceHuman MUC1 is over-expressed in human adenocarcinomas and has been used as a target for immunotherapy studies. The 9-mer MUC1-9 peptide has been identified as one of the peptides which binds to murine MHC class I H-2K. The structure of MUC1-9 in complex with H-2K has been modeled and simulated with classical molecular dynamics, based on the x-ray structure of the SEV9 peptide/H-2K complex. Two independent trajectories with the solvated complex (10 ns in length) were produced. Approximately 12 hydrogen bonds were identified during both trajectories to contribute to peptide/MHC complex, as well as 1-2 water mediated hydrogen bonds. Stability of the complex was also confirmed by buried surface area analysis, although the corresponding values were about 20% lower than those of the original x-ray structure. Interestingly, a bulged conformation of the peptide's central region, partially characterized as a -turn, was found exposed form the binding groove. In addition, P1 and P9 residues remained bound in the A and F binding pockets, even though there was a suggestion that P9 was more flexible. The complex lacked numerous water mediated hydrogen bonds that were present in the reference peptide x-ray structure. Moreover, local displacements of residues Asp4, Thr5 and Pro9 resulted in loss of some key interactions with the MHC molecule. This might explain the reduced affinity of the MUC1-9 peptide, relatively to SEV9, for the MHC class I H-2K

Ordering dynamics of microscopic models with nonconserved order parameter of continuous symmetry

Numerical Monte Carlo temperature-quenching experiments have been performed on two three-dimensional classical lattice models with continuous ordering symmetry: the Lebwohl-Lasher model [Phys. Rev. A 6, 426 (1972)] and the ferromagnetic isotropic Heisenberg model. Both models describe a transition from a disordered phase to an orientationally ordered phase of continuous symmetry. The Lebwohl-Lasher model accounts for the orientational ordering properties of the nematic-isotropic transition in liquid crystals and the Heisenberg model for the ferromagnetic-paramagnetic transition in magnetic crystals. For both models, which have a nonconserved order parameter, it is found that the linear scale, R(t), of the evolving order, following quenches to below the transition temperature, grows at late times in an effectively algebraic fashion, R(t)∼tn, with exponent values which are strongly temperature dependent and furthermore vary for different measures of the time-dependent length scale. The results are discussed in relation to modern theories of ordering dynamics in systems with continuous order-parameter symmetry

Virgo Detector Characterization and Data Quality during the O3 run

The Advanced Virgo detector has contributed with its data to the rapid growth of the number of detected gravitational-wave signals in the past few years, alongside the two LIGO instruments. First, during the last month of the Observation Run 2 (O2) in August 2017 (with, most notably, the compact binary mergers GW170814 and GW170817) and then during the full Observation Run 3 (O3): an 11 months data taking period, between April 2019 and March 2020, that led to the addition of about 80 events to the catalog of transient gravitational-wave sources maintained by LIGO, Virgo and KAGRA. These discoveries and the manifold exploitation of the detected waveforms require an accurate characterization of the quality of the data, such as continuous study and monitoring of the detector noise. These activities, collectively named {\em detector characterization} or {\em DetChar}, span the whole workflow of the Virgo data, from the instrument front-end to the final analysis. They are described in details in the following article, with a focus on the associated tools, the results achieved by the Virgo DetChar group during the O3 run and the main prospects for future data-taking periods with an improved detector.Comment: 86 pages, 33 figures. This paper has been divided into two articles which supercede it and have been posted to arXiv on October 2022. Please use these new preprints as references: arXiv:2210.15634 (tools and methods) and arXiv:2210.15633 (results from the O3 run

Virgo Detector Characterization and Data Quality: results from the O3 run

The Advanced Virgo detector has contributed with its data to the rapid growth of the number of detected gravitational-wave (GW) signals in the past few years, alongside the two Advanced LIGO instruments. First during the last month of the Observation Run 2 (O2) in August 2017 (with, most notably, the compact binary mergers GW170814 and GW170817), and then during the full Observation Run 3 (O3): an 11-months data taking period, between April 2019 and March 2020, that led to the addition of about 80 events to the catalog of transient GW sources maintained by LIGO, Virgo and now KAGRA. These discoveries and the manifold exploitation of the detected waveforms require an accurate characterization of the quality of the data, such as continuous study and monitoring of the detector noise sources. These activities, collectively named {\em detector characterization and data quality} or {\em DetChar}, span the whole workflow of the Virgo data, from the instrument front-end hardware to the final analyses. They are described in details in the following article, with a focus on the results achieved by the Virgo DetChar group during the O3 run. Concurrently, a companion article describes the tools that have been used by the Virgo DetChar group to perform this work.Comment: 57 pages, 18 figures. To be submitted to Class. and Quantum Grav. This is the "Results" part of preprint arXiv:2205.01555 [gr-qc] which has been split into two companion articles: one about the tools and methods, the other about the analyses of the O3 Virgo dat