105 research outputs found
Post-Translational Inhibition of IP-10 Secretion in IEC by Probiotic Bacteria: Impact on Chronic Inflammation
Peer reviewedPublisher PD
Comparative and Joint Analysis of Two Metagenomic Datasets from a Biogas Fermenter Obtained by 454-Pyrosequencing
Biogas production from renewable resources is attracting increased attention as an alternative energy source due to the limited availability of traditional fossil fuels. Many countries are promoting the use of alternative energy sources for sustainable energy production. In this study, a metagenome from a production-scale biogas fermenter was analysed employing Roche's GS FLX Titanium technology and compared to a previous dataset obtained from the same community DNA sample that was sequenced on the GS FLX platform. Taxonomic profiling based on 16S rRNA-specific sequences and an Environmental Gene Tag (EGT) analysis employing CARMA demonstrated that both approaches benefit from the longer read lengths obtained on the Titanium platform. Results confirmed Clostridia as the most prevalent taxonomic class, whereas species of the order Methanomicrobiales are dominant among methanogenic Archaea. However, the analyses also identified additional taxa that were missed by the previous study, including members of the genera Streptococcus, Acetivibrio, Garciella, Tissierella, and Gelria, which might also play a role in the fermentation process leading to the formation of methane. Taking advantage of the CARMA feature to correlate taxonomic information of sequences with their assigned functions, it appeared that Firmicutes, followed by Bacteroidetes and Proteobacteria, dominate within the functional context of polysaccharide degradation whereas Methanomicrobiales represent the most abundant taxonomic group responsible for methane production. Clostridia is the most important class involved in the reductive CoA pathway (Wood-Ljungdahl pathway) that is characteristic for acetogenesis. Based on binning of 16S rRNA-specific sequences allocated to the dominant genus Methanoculleus, it could be shown that this genus is represented by several different species. Phylogenetic analysis of these sequences placed them in close proximity to the hydrogenotrophic methanogen Methanoculleus bourgensis. While rarefaction analyses still indicate incomplete coverage, examination of the GS FLX Titanium dataset resulted in the identification of additional genera and functional elements, providing a far more complete coverage of the community involved in anaerobic fermentative pathways leading to methane formation
Minimal Length Scale Scenarios for Quantum Gravity
We review the question of whether the fundamental laws of nature limit our
ability to probe arbitrarily short distances. First, we examine what insights
can be gained from thought experiments for probes of shortest distances, and
summarize what can be learned from different approaches to a theory of quantum
gravity. Then we discuss some models that have been developed to implement a
minimal length scale in quantum mechanics and quantum field theory. These
models have entered the literature as the generalized uncertainty principle or
the modified dispersion relation, and have allowed the study of the effects of
a minimal length scale in quantum mechanics, quantum electrodynamics,
thermodynamics, black-hole physics and cosmology. Finally, we touch upon the
question of ways to circumvent the manifestation of a minimal length scale in
short-distance physics.Comment: Published version available at
http://www.livingreviews.org/lrr-2013-
Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats
New varying speed of light theories
We review recent work on the possibility of a varying speed of light (VSL).
We start by discussing the physical meaning of a varying , dispelling the
myth that the constancy of is a matter of logical consistency. We then
summarize the main VSL mechanisms proposed so far: hard breaking of Lorentz
invariance; bimetric theories (where the speeds of gravity and light are not
the same); locally Lorentz invariant VSL theories; theories exhibiting a color
dependent speed of light; varying induced by extra dimensions (e.g. in the
brane-world scenario); and field theories where VSL results from vacuum
polarization or CPT violation. We show how VSL scenarios may solve the
cosmological problems usually tackled by inflation, and also how they may
produce a scale-invariant spectrum of Gaussian fluctuations, capable of
explaining the WMAP data. We then review the connection between VSL and
theories of quantum gravity, showing how ``doubly special'' relativity has
emerged as a VSL effective model of quantum space-time, with observational
implications for ultra high energy cosmic rays and gamma ray bursts. Some
recent work on the physics of ``black'' holes and other compact objects in VSL
theories is also described, highlighting phenomena associated with spatial (as
opposed to temporal) variations in . Finally we describe the observational
status of the theory. The evidence is currently slim -- redshift dependence in
the atomic fine structure, anomalies with ultra high energy cosmic rays, and
(to a much lesser extent) the acceleration of the universe and the WMAP data.
The constraints (e.g. those arising from nucleosynthesis or geological bounds)
are tight, but not insurmountable. We conclude with the observational
predictions of the theory, and the prospects for its refutation or vindication.Comment: Final versio
Quantum Spacetime Phenomenology
I review the current status of phenomenological programs inspired by
quantum-spacetime research. I stress in particular the significance of results
establishing that certain data analyses provide sensitivity to effects
introduced genuinely at the Planck scale. And my main focus is on
phenomenological programs that managed to affect the directions taken by
studies of quantum-spacetime theories.Comment: 125 pages, LaTex. This V2 is updated and more detailed than the V1,
particularly for quantum-spacetime phenomenology. The main text of this V2 is
about 25% more than the main text of the V1. Reference list roughly double
Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish
Application of a hierarchical enzyme classification method reveals the role of gut microbiome in human metabolism
Cognitive Representations (Metaphorical Conceptualizations) of PAST, FUTURE, JOY, SADNESS and HAPPINESS in Depressive and Non-depressive Subjects: Cognitive Distortions in Depression at the Level of Notion
Semantic Distances in Depression: Relations Between ME and PAST, FUTURE, JOY, SADNESS, HAPPINESS
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