Ultrafine conducting fibers: metallization of poly(acrylonitrile-co-glycidyl methacrylate) nanofibers

Electrospun poly(glycidylmethacrylate) (PGMA) and poly(acrylonitrile-co-glycidyl methacrylate) (P(AN-GMA)) nanofibers were coated with monodisperse silver nanoparticles by using an electroless plating technique at ambient conditions. Oxirane groups on the surface of nanofibers were replaced with reducing agent, hydrazine. Surface modified nanofibers were allowed to react with ammonia solution of AgNO3. A redox reaction takes place and metallic silver nucleate on fibers surface. Parameters affecting the particle size were determined

Ultra-Rare Genetic Variation in the Epilepsies : A Whole-Exome Sequencing Study of 17,606 Individuals

Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious variation in less-severe forms of epilepsy. To identify the shared and distinct ultra-rare genetic risk factors for different types of epilepsies, we performed a whole-exome sequencing (WES) analysis of 9,170 epilepsy-affected individuals and 8,436 controls of European ancestry. We focused on three phenotypic groups: severe developmental and epileptic encephalopathies (DEEs), genetic generalized epilepsy (GGE), and non-acquired focal epilepsy (NAFE). We observed that compared to controls, individuals with any type of epilepsy carried an excess of ultra-rare, deleterious variants in constrained genes and in genes previously associated with epilepsy; we saw the strongest enrichment in individuals with DEEs and the least strong in individuals with NAFE. Moreover, we found that inhibitory GABA(A) receptor genes were enriched for missense variants across all three classes of epilepsy, whereas no enrichment was seen in excitatory receptor genes. The larger gene groups for the GABAergic pathway or cation channels also showed a significant mutational burden in DEEs and GGE. Although no single gene surpassed exome-wide significance among individuals with GGE or NAFE, highly constrained genes and genes encoding ion channels were among the lead associations; such genes included CACNAIG, EEF1A2, and GABRG2 for GGE and LGI1, TRIM3, and GABRG2 for NAFE. Our study, the largest epilepsy WES study to date, confirms a convergence in the genetics of severe and less-severe epilepsies associated with ultra-rare coding variation, and it highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.Peer reviewe

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd

Distopyan Perspektiften Bilgi İletişim Teknolojileri ve İnsanlığın Geleceği

The lives of human beings are changing fundamentally by the increased importance attached to scientific thought though modernism and by the new improvements in technology. This brings forth positive and negative consequences. Even though information communication technologies are considerable actors of information era, the problems arise from the production, dissemination and usage of these technologies have not been impeded yet. Certainly, the existence of such problems brings forth ;amp;#8216;dystopian;amp;#8217; foresights for our future which is going to take shape by new technologies. On the contrary of ;amp;#8216;utopian;amp;#8217; foresights that claim ideal political, economical and cultural structures by the usage of information communication technologies, many researchers depict ;amp;#8216;dystopian;amp;#8217; foresights that claim more intense problems in future arising from the deployment of these technologies. In this study, various problems revealed from information communication technologies are examined and dystopian foresights related with these technologies are explored.Modernizmle birlikte bilimsel düşünceye verilen önemin artması ve buna koşut olarak gerçekleşen teknolojik ilerlemeler, insanoğlunun yaşamını oldukça farklılaştırmakta, beraberinde çeşitli olumlu ve olumsuz sonuçları getirmektedir. Bilgi çağının yaşandığı günümüz dünyasında, bilgi iletişim teknolojileri, çağın en önemli aktörü olmayı başarmış, bununla beraber bu teknolojilerinin üretiminden, dağılımından ve kullanımından kaynaklanan çeşitli sorunların doğmasına engel olunamamıştır. Kuşkusuz bu sorunların varlığı bilgi iletişim teknolojileriyle şekillenecek geleceğe dair ‘distopyan’ öngörüleri beraberinde getirmektedir. Gelecekte, bilgi iletişim teknolojilerinin neden olacağı ideal siyasal, ekonomik, kültürel yapılardan söz eden ‘ütopyan’ öngörülerin aksine bilgi iletişim teknolojileriyle dünyamızdaki mevcut sorunların gelecekte daha da derinleşeceği üzerinde duran distopyan öngörüler çeşitli araştırmacılar ve düşünürler tarafından dile getirilmektedir. Bu çalışmada, bilgi iletişim teknolojileri ile şekillenecek geleceğe dair söz konusu distopyan öngörüler, bu öngörülerin ortaya çıkmasına neden olan günümüzdeki mevcut sorunlarla birlikte incelenmektedir

Prognostic factors for renal cell carcinoma

An elementary phenomenological consideration is presented regarding the longwavelength quantum dynamics in cuprate superconductors. The emphasis is on theinterplay of the charge- and spin order associated with the stripe phenomenonon the one hand, and superconductivity on the other hand

Vertebral fracture associated with shockwave lithotripsy in a patient with granulomatous spondylitis.

Extracorporeal shockwave lithotripsy (SWL) is an accepted treatment modality in the treatment of urinary stone disease. Many complications have been reported secondary to high-energy shockwaves, but the effects of SWL on the skeletal system have rarely been investigated. We represent the first case of a burst-type vertebral fracture after SWL in an elderly osteoporotic patient with granulomatous spondylitis