Hermite Fonksiyonları, mRMR Yöntemi ve Yapay Sinir Ağları Kullanarak EKG İşaretlerinin Sınıflandırılması

Bu çalışmada EKG işaretlerinin sınıflandırılmasında yapay sinir ağları kullanılmıştır. Giriş vektörünün boyutunu azaltmak için elektrokardiyogram işareti öncelikle Hermite fonksiyonları cinsinden ifade edilerek bir katsayı vektörü elde edilmiş, ardından mRMR yöntemi ile katsayı vektörü içerisinden etkili öznitelik grubu seçilmiştir. Sınıflandırıcı başarısını arttırmak için zaman düzleminde bazı öznitelikler türetilmiş ve öznitelik vektörüne eklenmiştir. Son olarak mRMR yöntemi uygulanarak elde edilen farklı uzunluktaki (5, 10, 15 ve 20) öznitelik vektörleri kullanılarak hesaplanan sınıflandırıcı sonuçları ile Hermite fonksiyonlarına göre belirlenen farklı uzunluktaki (5, 10, 15 ve 20) öznitelik vektörleri için bulunan sınıflandırıcı sonuçları kıyaslanmıştır

IgG and IgG2 antibody responses to a pneumococcal capsular polysaccharide vaccine in patients with asthma and chronic obstructive pulmonary disease Astim ve kronik obstrüktif akciǧer hastalikli bireylerde pnömokokal kapsüler polisakkarit aşisina karşi oluşan IgG VE IgG2 antikor yanitlari

Streptococcus pneumoniae is the most common cause of community acquired pneumonia. Pneumococcal infections are responsible for substantial morbidity and mortality worldwide due to the increasing rate of penicillin resistance. Therefore pneumococcal vaccine is highly recommended to the high risk groups. In this study, we aimed to investigate the antibody response to Pneumo-23 vaccine in high risk groups especially for the patients with asthma and chronic obstructive lung disease (COLD) and to detect IgG and IgG2 isotype antibody levels against the pneumococcal capsular polysaccharide antigens by ELISA method, in 41 patients aged between 44-85 years. Prevaccination IgG and IgG2 levels above threshold were determined in 83% and 51% of the patients respectively, whereas these rates have been detected as 93% and 90% respectively, one month after the vaccination. Immunologic response to the vaccine (seroconversion) was detected in 41% of patients for IgG and in 63% of patients for IgG2. Anti-pneumococcal antibody mean levels were found to be significantly higher after vaccination (p0.05). In conclusion, pneumococcal vaccine might be beneficial to increase the level of preexisting pneumococcal antibodies and to protect the risk groups especially elderly people and COLD patients

Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study

Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST).Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients.Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter.Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST

Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study

Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST). Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients. Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter. Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST.WOS:0005375741000192-s2.0-85083703251PubMed: 3235381