1,994 research outputs found
Discovery of a Galaxy Cluster via Weak Lensing
We report the discovery of a cluster of galaxies via its weak gravitational
lensing effect on background galaxies, the first spectroscopically confirmed
cluster to be discovered through its gravitational effects rather than by its
electromagnetic radiation. This fundamentally different selection mechanism
promises to yield mass-selected, rather than baryon or photon-selected, samples
of these important cosmological probes. We have confirmed this cluster with
spectroscopic redshifts of fifteen members at z=0.276, with a velocity
dispersion of 615 km/s. We use the tangential shear as a function of source
photometric redshift to estimate the lens redshift independently and find z_l =
0.30 +- 0.08. The good agreement with the spectroscopy indicates that the
redshift evolution of the mass function may be measurable from the imaging data
alone in shear-selected surveys.Comment: revised version with minor changes, to appear in ApJ
Size-selective nanoparticle growth on few-layer graphene films
We observe that gold atoms deposited by physical vapor deposition onto few
layer graphenes condense upon annealing to form nanoparticles with an average
diameter that is determined by the graphene film thickness. The data are well
described by a theoretical model in which the electrostatic interactions
arising from charge transfer between the graphene and the gold particle limit
the size of the growing nanoparticles. The model predicts a nanoparticle size
distribution characterized by a mean diameter D that follows a scaling law D
proportional to m^(1/3), where m is the number of carbon layers in the few
layer graphene film.Comment: 15 pages, 4 figure
Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ-1 subunits
BACKGROUND: Following peripheral nerve chronic constriction injury, the accumulation of the α2δ-1 auxiliary subunit of voltage-gated Ca2+channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ-1 in Xenopus oocytes increases the opening properties of Cav1.2 L-type channels and allows Ca2+influx at physiological membrane potentials. We therefore posited that L-type channels play a role in neurotransmitter release in the superficial dorsal horn in the chronic constriction injury model of neuropathic pain. RESULTS: Whole-cell recording from lamina II neurons from rats, subject to sciatic chronic constriction injury, showed that the L-type Ca2+channel blocker, nitrendipine (2 µM) reduced the frequency of spontaneous excitatory postsynaptic currents. Nitrendipine had little or no effect on spontaneous excitatory postsynaptic current frequency in neurons from sham-operated animals. To determine whether α2δ-1 is involved in upregulating function of Cav1.2 L-type channels, we tested the effect of the α2δ-1 ligand, gabapentin (100 µM) on currents recorded from HEK293F cells expressing Cav1.2/β4/α2δ-1 channels and found a significant decrease in peak amplitude with no effect on control Cav1.2/β4/α2δ-3 expressing cells. In PC-12 cells, gabapentin also significantly reduced the endogenous dihydropyridine-sensitive calcium current. In lamina II, gabapentin reduced spontaneous excitatory postsynaptic current frequency in neurons from animals subject to chronic constriction injury but not in those from sham-operated animals. Intraperitoneal injection of 5 mg/kg nitrendipine increased paw withdrawal threshold in animals subject to chronic constriction injury. CONCLUSION: We suggest that L-type channels show an increased contribution to synaptic transmission in lamina II dorsal horn following peripheral nerve injury. The effect of gabapentin on Cav1.2 via α2δ-1 may contribute to its anti-allodynic action
Sharp interface limits of phase-field models
The use of continuum phase-field models to describe the motion of
well-defined interfaces is discussed for a class of phenomena, that includes
order/disorder transitions, spinodal decomposition and Ostwald ripening,
dendritic growth, and the solidification of eutectic alloys. The projection
operator method is used to extract the ``sharp interface limit'' from phase
field models which have interfaces that are diffuse on a length scale . In
particular,phase-field equations are mapped onto sharp interface equations in
the limits and , where and are
respectively the interface curvature and velocity and is the diffusion
constant in the bulk. The calculations provide one general set of sharp
interface equations that incorporate the Gibbs-Thomson condition, the
Allen-Cahn equation and the Kardar-Parisi-Zhang equation.Comment: 17 pages, 9 figure
Diverse syntrophic partnerships from deep-sea methane vents revealed by direct cell capture and metagenomics
Microorganisms play a fundamental role in the cycling of nutrients and energy on our planet. A common strategy for many microorganisms mediating biogeochemical cycles in anoxic environments is syntrophy, frequently necessitating close spatial proximity between microbial partners. We are only now beginning to fully appreciate the diversity and pervasiveness of microbial partnerships in nature, the majority of which cannot be replicated in the laboratory. One notable example of such cooperation is the interspecies association between anaerobic methane oxidizing archaea (ANME) and sulfate-reducing bacteria. These consortia are globally distributed in the environment and provide a significant sink for methane by substantially reducing the export of this potent greenhouse gas into the atmosphere. The interdependence of these currently uncultured microbes renders them difficult to study, and our knowledge of their physiological capabilities in nature is limited. Here, we have developed a method to capture select microorganisms directly from the environment, using combined fluorescence in situ hybridization and immunomagnetic cell capture. We used this method to purify syntrophic anaerobic methane oxidizing ANME-2c archaea and physically associated microorganisms directly from deep-sea marine sediment. Metagenomics, PCR, and microscopy of these purified consortia revealed unexpected diversity of associated bacteria, including Betaproteobacteria and a second sulfate-reducing Deltaproteobacterial partner. The detection of nitrogenase genes within the metagenome and subsequent demonstration of 15N2 incorporation in the biomass of these methane-oxidizing consortia suggest a possible role in new nitrogen inputs by these syntrophic assemblages
The Lantern Vol. 13, No. 1, October 1944
• One Doctor\u27s Story • Sonnet for a Friend • Lines and a Sonnet • Chant • Circus Impressions • Spring Comes Latehttps://digitalcommons.ursinus.edu/lantern/1034/thumbnail.jp
- …