702 research outputs found
Openness, Technological Change and Labor Demand in Pre-Crisis Indonesia.
This paper examines the impact of export orientation, import competition, foreign ownership and the rate of capital accumulation on the relative demand for skilled and unskilled labor in pre-crisis Indonesia.TRADE ; COMPETITION ; LABOUR MARKET
Grizzly Bears and Humans at Alpine Moth Sites in Wyoming, USA
Army cutworm moths (Euxoa auxiliaris; moths) are an important seasonal higher elevational food source for grizzly bears (Ursus arctos horribilis; bears) in the Greater Yellowstone Ecosystem (Wyoming, Montana, and Idaho, USA). Increased human interaction with bears at moth sites is an important management issue because of the potential for displacing bears and the concern for human safety. Managers will need better information regarding humanâbear interactions at high-density moth sites that are also accessible to humans to mitigate potential conflicts. In the summers of 2017 and 2018, we studied humanâbear interactions at 2 of the most human accessible moth sites in the Shoshone National Forest, Wyoming. We completed 293 bear surveys and documented 266 bear observations. We also recorded human-use levels at the 2 study sites (north site: 3 groups/year; south site: 35 groups/year). We documented 43 interactions (at the south site only) and obtained location data for 29 interactions. During humanâbear interactions, bears strongly avoided humans 80% of the time and had no apparent reaction 20% of the time. Our results indicated that human safety and bear displacement are valid management concerns at the south site. Human safety concerns were most apparent in mountain climbing groups with small group sizes (people, n = 64/70) that were unprepared for encounters with bears. Management concerns for human safety and bear displacement are much lower at the north site. We recommend placing information kiosks at trailheads to inform hikers of dangers associated with grizzly bear concentrations on moth sites
Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease
Neural stem cells (NSCs) are widely endorsed as a cell source for replacement strategies in neurodegenerative disease. However, their usefulness is currently limited by the inability to induce specific neurotransmitter phenotypes in these cells. In order to direct dopaminergic neuronal fate, we overexpressed Pitx3 in NSCs that were then exposed to E11 developing ventral mesencephalon (VM) in explant culture. This resulted in a significant potentiation of dopaminergic differentiation of the cells. When transplanted into the 6-hydroxydopamine lesioned Parkinsonian rats, these cografts of VM and Pitx3 overexpressing NSCs resulted in a significant restitution of motor function. In addition, there were greater numbers of Girk2 positive A9 neurons in the periphery of the transplants that were NSC derived. This demonstrates that given the correct signals, NSCs can be induced to become dopaminergic neurons that can differentiate into the correct nigrastriatal phenotype required for the treatment of Parkinson's diseas
The BioGRID Interaction Database: 2011 update
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein
interaction data from model organisms and humans
(http://www.thebiogrid.org). BioGRID currently holds 347 966
interactions (170 162 genetic, 177 804 protein) curated from both
high-throughput data sets and individual focused studies, as derived
from over 23 000 publications in the primary literature. Complete
coverage of the entire literature is maintained for budding yeast
(Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe)
and thale cress (Arabidopsis thaliana), and efforts to expand curation
across multiple metazoan species are underway. The BioGRID houses 48
831 human protein interactions that have been curated from 10 247
publications. Current curation drives are focused on particular areas
of biology to enable insights into conserved networks and pathways that
are relevant to human health. The BioGRID 3.0 web interface contains
new search and display features that enable rapid queries across
multiple data types and sources. An automated Interaction Management
System (IMS) is used to prioritize, coordinate and track curation
across international sites and projects. BioGRID provides interaction
data to several model organism databases, resources such as Entrez-Gene
and other interaction meta-databases. The entire BioGRID 3.0 data
collection may be downloaded in multiple file formats, including PSI MI
XML. Source code for BioGRID 3.0 is freely available without any
restrictions
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