Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods. https://www.trialregister.nl/trial/795

Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context

The endeavor to understand the human brain has seen more progress in the last few decades than in the previous two millennia. Still, our understanding of how the human brain relates to behavior in the real world and how this link is modulated by biological, social, and environmental factors is limited. To address this, we designed the Healthy Brain Study (HBS), an interdisciplinary, longitudinal, cohort study based on multidimensional, dynamic assessments in both the laboratory and the real world. Here, we describe the rationale and design of the currently ongoing HBS. The HBS is examining a population-based sample of 1,000 healthy participants (age 30-39) who are thoroughly studied across an entire year. Data are collected through cognitive, affective, behavioral, and physiological testing, neuroimaging, bio-sampling, questionnaires, ecological momentary assessment, and real-world assessments using wearable devices. These data will become an accessible resource for the scientific community enabling the next step in understanding the human brain and how it dynamically and individually operates in its bio-social context. An access procedure to the collected data and bio-samples is in place and published on https://www.healthybrainstudy.nl/en/data-and-methods/access. Trail registration: https://www.trialregister.nl/trial/7955

Absence of antimicrobial activity of Euphorbia milii molluscicidal latex.

Abstract: Introduction : Euphorbia milii latex has been used as herbal medicine and proved to be a potent plant molluscicide. Materials and Methods : The susceptibility of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa to E. milii molluscicidal latex was evaluated by assays in the agar well diffusion method and tubes dilution, to determine the minimal inhibitory concentration and minimal bactericidal concentration. Results : Latex in natura (fresh) and lyophilized in a maximum viable concentration of 100 mg/L did not show any inhibitory effect on the growth of the bacterial strains tested. Conclusion : Although it has been effective as a molluscicide, this latex presented a total absence of antimicrobial activity in the two forms and concentrations tested

Absence of antimicrobial activity of Euphorbia milii molluscicidal latex.

Abstract: Introduction : Euphorbia milii latex has been used as herbal medicine and proved to be a potent plant molluscicide. Materials and Methods : The susceptibility of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa to E. milii molluscicidal latex was evaluated by assays in the agar well diffusion method and tubes dilution, to determine the minimal inhibitory concentration and minimal bactericidal concentration. Results : Latex in natura (fresh) and lyophilized in a maximum viable concentration of 100 mg/L did not show any inhibitory effect on the growth of the bacterial strains tested. Conclusion : Although it has been effective as a molluscicide, this latex presented a total absence of antimicrobial activity in the two forms and concentrations tested.Made available in DSpace on 2019-05-25T00:32:35Z (GMT). No. of bitstreams: 1 JPharmNegativeResults31133790589103145.pdf: 599045 bytes, checksum: 591eb84e8b120057781cb7d8c7393c77 (MD5) Previous issue date: 2012bitstream/item/197722/1/JPharmNegativeResults3113-3790589-103145.pd