10 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
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- Andrade V.
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- Belezhanska D.
- Bellenguez Céline
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- Below J.E.
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- Solomon A.
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- Spallazzi M.
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- Stern R.A.
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- Stordal E.
- Strandberg T.
- Strauss E.
- Strittmatter S.M.
- Ståhlbom A.K.
- Sultzer D.
- Suominen L.
- Sussams R.
- Swerdlow R.H.
- Sáez María Eugenia
- Sánchez-Arjona M.B.
- Sánchez-Valle R.
- Takalo M.
- Tanzi R.E.
- Tartan J.P.
- Tasanen K.
- Taskinen M.R.
- Teipel S.
- Teng E.
- Tesí N.
- Teumer A.
- Thalamuthu A.
- Thomas A.
- Thomas C.
- Thomas T.
- Thomassen J.Q.
- Thonberg H.
- Tienari P.
- Tilson J.L.
- Tin A.
- Todd S.
- Toso C.R.
- Tosto G.
- Traykov L.
- Tremolizzo L.
- Trojanowski J.Q.
- Troncoso J.C.
- Tsai E.
- Tsolaki A.
- Tsolaki M.
- Tsuang D.W.
- Tsuo K.
- Tucker-Drob E.
- Tukiainen T.
- Tuomi T.
- Tuomilehto J.
- Tuovila O.
- Turpeinen M.
- Turton J.
- Turunen J.A.
- Tybjærg-Hansen A.
- Tzourio C.
- Tárraga L.
- Uitterlinden A.
- Ullgren A.
- Ulstein I.
- Universitat Autònoma de Barcelona
- Uphill J.
- Usiskin K.
- Uusitalo H.
- Uusitalo-Järvinen H.
- Vacca A.
- Vainio S.
- Valero S.
- Valladares O.
- Valladares O.
- van Adelsberg J.
- Van Deerlin V.M.
- van den Bussche H.
- van der Flier Wiesje M
- van der Lee S.J.
- van der Lugt A.
- van Duijn C.M.
- van Eldik L.J.
- van Lent D.M.
- van Rooij J.
- van Swieten J.
- Vance J.
- Vandenberghe R.
- Vardarajan B.N.
- Vardy E.
- Vargas L.
- Vassar R.
- Verhey F.
- Vicente M. P.
- Vidal J.S.
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vilas R.H.
- Vinters H.V.
- Virolainen P.
- Vivancos L.
- Vogelgsang J.
- Vojinovic D.
- Vonsattel J.P.
- Voutilainen M.
- Vyhnalek M.
- Wadhawan S.
- Wagner M.
- Wallon D.
- Wang C.
- Wang L.S.
- Wang R.
- Wang Y.
- Warden D.
- Waring J.
- Waring J.
- Warner N.
- Warren J.D.
- Waterworth D.
- Weber H.
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K.A.
- Whelan C.
- Whitehead P.L.
- Wichmann H.E.
- Wigmore E.
- Wijsman E.M.
- Wilcock G.
- Wilhelmsen K.C.
- Williams A.
- Williams B.
- Williams D.
- Williams J.
- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T.S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R.L.
- Wong R.
- Woods B.
- Woon M.
- Wright C.B.
- Wu C.K.
- Wu Y.
- Xia T.h.
- Xu E.
- Xu F.
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Younkin S.G.
- Yu C.E.
- Yu L.
- Zare H.
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C.P.
- Zompo M.D.
- Zulaica M.
- Álvarez V.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Secure evolvable hardware for public-key cryptosystems
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Optical mapping of the thoracoabdominal wall.
- Author
- A J Peacock
- Ainsworth H.
- Beard L.F.H.
- Burke P.H.
- C Turton
- Cobb J.
- D M Denison
- Denison D.M.
- Duncan J.
- Fallschurch
- Fallschurch
- Gourlay A.R.
- Greguss P.
- Grew N.D.
- Hok B.
- Joel H.C.
- Kovats F.
- Lovesey E.J.
- Lovesey E.J.
- M D Morgan
- Madden M.C.
- MC Van Wijk
- Roger R.E.
- S Gourlay
- Saumarez R.C.
- Takasaki H.
- Takasaki H.
- Takasaki H.
- Whittle M.W.
- Publication venue
- 'BMJ'
- Publication date
- Field of study
Departures from everyday resistance and flexible strategies of domination: The making and unmaking of a poor peasant mobilization in Bangladesh
- Author
- Adas Michael
- Adnan Shapan
- Adnan Shapan
- Adnan Shapan
- Adnan Shapan
- Alavi Hamza
- Broomfield J.H.
- Gramsci Antonio
- Guha Ranajit
- Hobsbawm E.J.
- Hughes R.
- Kerkvliet Benedict J. Tria
- Kerkvliet Benedict J. Tria
- Kula Witold
- Nicholas Ralph W.
- Nicholas Ralph W.
- Rahman Anisur
- Rude George
- Scott James C.
- Scott James C.
- Skocpol Theda
- Thorp J.P.
- Turton Andrew
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2007
- Field of study
10.1111/j.1471-0366.2007.00144.xJournal of Agrarian Change72183-22
Acceptance and Commitment Therapy plus usual care for improving quality of life in people with motor neuron disease (COMMEND): a multicentre, parallel, randomised controlled trial in the UK
- Author
- Al-Chalabi A.
- Baker I.
- Bradburn M.
- Bursnall M.
- Chhetr S.K.
- Cooper C.
- Ealing J.
- Faull C.
- Goldstein L.H.
- Gorrie G.H.
- Gould R.L.
- Graham C.D.
- Gunawardana N.
- Hanratty A.
- Howard R.J.
- Kumar P.
- Lambert T.
- Lawrence V.
- McCracken L.M.
- McDermott C.J.
- Meadows G.
- Noad R.
- Orrell R.W.
- Radunovic A.
- Rawlinson C.V.
- Serfaty M.A.
- Shaw P.J.
- Thompson B.J.
- Turton E.J.
- White D.A.
- Williams T.
- Young T.
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Re-spacing African drylands:territorialization, sedentarization and indigenous commodification in the Ethiopian pastoral frontier
- Author
- Aalen L.
- Abbink J.
- Barth F.
- Baumann M.P.O.
- Benedikt Korf
- Beyene F.
- Blench R.
- Boone C.
- Brons M.
- Catley A.
- Colchester M.
- Cossins N.J.
- Cossins Noel J.
- Cotula L.
- Deleuze G.
- Devereux S.
- Donham D.L.
- Farah Ahmed Y.
- FDRE (Federal Democratic Republic of Ethiopia)
- FDRE (Federal Democratic Republic of Ethiopia)
- Galaty J.G.
- Garretson P.
- Geiger D.
- Geshekter C.L.
- Hagmann T.
- Hagmann T.
- Harvey D.
- Herbst J.
- Hogg R.
- Holcomb B.K.
- Homewood K.
- Imperial Ethiopian Government
- Kassa G.
- Keller E.J.
- Lewis I.M.
- Little P.D.
- Little P.D.
- Majid N.
- Markakis J.
- Markakis J.
- Pankhurst A.
- Rahmato D.
- Rony Emmenegger
- Sack R.D.
- Salih M.A. Mohamed
- Salzman P.C.
- Save the Children Fund
- Schmitt C.
- Scoones I.
- Scott J.C.
- Scott J.C.
- Sugule Jama
- Thompson E.P.
- Tobias Hagmann
- Turton D.
- Ugas M.
- UNDP (United Nations Development Programme)
- van Brabant K.
- Verne J.
- Zewde Bahru.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2015
- Field of study
This paper traces the re-spacing of pastoral drylands in Africa. We argue that rendering pastoral resources legible and profitable occurs both within and beyond the state. Through a multi-sited case study from Ethiopia's Somali region, we excavate different mechanisms of sedentarization, whereby processes of state territorialization and indigenous commodification become mutually entangled. Sedentarization is not imposed by the state or corporate capital, but by indigenous merchants who capture the frontier's potential resource dividend. Land appropriation in the drylands is co-produced by political claims to territory, capital investment and new technopolitics through which indigenous (pastoral, Somali) merchants and politicians become complicit with the state's project of territorialization and sedentarization in a self-governing fashion. The irony of this situation is that the (Ethiopian) state has failed to consolidate sedentarization through planned interventions. Instead, capital investment by local and transnational Somali merchants has opened up a neoliberal frontier that re-spaces drylands towards increasing sedentarization
‘Peace-building as state-building’? Rethinking liberal interventionism in contexts of emerging states
- Author
- Allawi A.
- Anderson B.R.
- Annan K.A.
- Ariye E.C.
- Bayart J.-F.
- Bayly C.A.
- Biró D.
- Bose S.
- Brinkerhoff D.
- Böge V.
- Böge V.
- Call C.
- Call C.
- Call C.
- Callahan M.P.
- Chandler D.
- Chesterman S.
- Cliffe S.
- Colley L.
- Cramer C.
- Davis M.
- Deutsch K.
- Dominik Balthasar
- Doyle M.W.
- Duffield M.
- Enzensberger H.M.
- Ferguson R.B.
- Fichte J.
- Fukuyama F.
- Furnivall J.S.
- Gellner E.
- Ghani A.
- Gomez D.
- Grävingholt J.
- Haider H.
- Hechter M.
- Herbst J.I.
- Herder J.
- Hobbes of Malmesbury T.
- Hobsbawm E.J.
- Howard M.E.
- Howard T.
- Huntington S.P.
- Jacquin-Berdal D.
- Kaldor M.
- Kaplan S.
- Keen D.
- Lidén K.
- Locke J.
- Maley W.
- Malone D.M.
- McNeill W.H.
- Newman E.
- Newman E.
- Organisation for Economic Co-Operation and Development (OECD)
- Organisation for Economic Co-Operation and Development (OECD)
- Osterhammel J.
- Ottaway M.
- Paris R.
- Patriota A.
- Polanyi K.
- Rashid A.
- Reinhard W.
- Renan E.
- Richards P.
- Richmond O.P.
- Ricks T.E.
- Ropp T.
- Röder P.
- Schwarz B.
- Scott Z.
- Simmel G.
- Szilagyi-Gal M.
- Tanabe J.
- Tilly C.
- Turton D.
- Turton D.
- United Nations
- United Nations
- van Creveld M.
- von Bogdandy A.
- Williams A.
- World Bank
- Zartman I.W.
- Zürcher C.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Molecular Epidemiology of Acinetobacter Species
- Author
- A. Belkum van
- A. Gouby
- A. Horrevorts
- A. Jawad
- A. McDonald
- A. Nemec
- A. Nemec
- A. Nemec
- A. Simhon
- A. Weernink
- A.E. Buxton
- A.I. Hartstein
- A.I. Hartstein
- A.M. Snelling
- A.S. Levin
- A.T. Bernards
- A.T. Bernards
- A.T. Bernards
- B. Schulte
- B.A. Cunha
- C. Cefai
- C. Webster
- C. Zeana
- C.A. Webster
- C.A. Webster
- C.A. Webster
- C.M. Beck-Sague
- D. Landman
- D.B. Dolinger von
- E. Abrutyn
- E. Kraniotaki
- E. Marais
- E.J. Feil
- E.K. Musa
- E.M. D’Agata
- E.S. Go
- E.Towner K.J Bergogne- Bérézin
- E.Z. Vegas De
- F. Bureau-Chalot
- G. Bou
- G. Huys
- G.J. Silva Da
- G.L. French
- H. Dessel van
- H. Seifert
- H. Seifert
- H. Seifert
- H. Seifert
- H. Seifert
- H. Seifert
- H. Seifert
- H. Wisplinghoff
- H. Wisplinghoff
- H. Wisplinghoff
- H. Wisplinghoff
- H.J. Grundmann
- I. Kappstein
- J. Ahmed
- J. Loubinoux
- J. Vila
- J.A. Ecker
- J.A. Karlowsky
- J.A. Lowes
- J.E. Patterson
- J.F. Turton
- J.F. Turton
- J.G. Koeleman
- J.G. Koeleman
- J.G. Koeleman
- J.H. Wagenvoort
- J.H. Yoo
- J.L. Garcia-Garmendia
- J.M. Cisneros
- J.M. Coelho
- J.W. Stone
- K.D. Allen
- L Poirel
- L. Dijkshoorn
- L. Dortet
- L.M. Deshpande
- M. Vaneechoutte
- M.C. Enright
- M.C. Maiden
- M.E. Griffith
- M.J. Struelens
- M.L. Ling
- M.M. Wroblewska
- M.O. Wright
- M.V. Villegas
- P. Baumann
- P. Bogaerts
- P. Gerner-Smidt
- P. Gerner-Smidt
- P. Janssen
- P.C. Ng
- P.E. Fournier
- P.R. Rhomberg
- P.W. Smith
- R. Dobrewski
- R. Zarrilli
- R.J. Seward
- R.J. Sherertz
- R.N. Jones
- R.P. Spence
- R.S. Irwin
- S. Brisse
- S. Misbah
- S. Silbert
- S.A. Roberts
- S.G. Bartual
- T. Naas
- T.V. Riley
- V. Thurm
- V.M. Manikal
- Y. Gräser
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Variation in the provision and practice of implant-based breast reconstruction in the UK: Results from the iBRA national practice questionnaire
- Author
- A. Akingboye
- A. Allan
- A. Carbone
- A. Conway
- A. Halka
- A. Hargreaves
- A. Hazari
- A. Jain
- A. Knight
- A. Reid
- A. Thorne
- A. Waterworth
- A.J. Volleamere
- A.R. Carmichael
- Abhilash Jain
- Ansar Farooq
- B. Pearce
- B. Smith
- Barber
- Berna
- Breuing
- Breuing
- C. Holcombe
- C. Holcombe
- C. Hoo
- C. Murphy
- C. Osborne
- C. Rogers
- Callaghan
- Casella
- Christopher Holcombe
- Clemens
- Cordeiro
- D. Banerjee
- D. Clarke
- D. Cocker
- D. Egbeare
- D. Egbeare
- D. Ferguson
- D. MacMillan
- D. Nguyen
- D. Westbroek
- Dieterich
- Dieterich
- Dieterich
- Dikmans
- Douek
- E. Baker
- E. Davies
- E. Nael
- E.J. Conroy
- E.M. Teasdale
- Elizabeth Conroy
- F. Conroy
- F. MacNeill
- F. Soliman
- F.A.K. Mazari
- F.S. Fahmy
- G. Irwin
- G. Irwin
- Gamboa-Bobadilla
- Gschwantler-Kaulich
- H. Deol
- H. Osman
- H. Tafazal
- Harris
- I. Athanasiou
- I. Azmy
- I. Dash
- I. Depasquale
- I. King
- I. Michalakis
- J. Harvey
- J. Henderson
- J. Henton
- J. Hu
- J. Leon-Villapalos
- J. Massey
- J. Piper
- J. Seward
- J. Skillman
- J. Smith
- J. Turner
- J. Winter Beatty
- J.M. Blazeby
- J.M. Skillman
- J.R. Dicks
- J.W. Roberts
- Jane M. Blazeby
- Jeevan
- Jeevan
- Joanna M. Skillman
- K. Anesti
- K. Bisarya
- K. Kirkpatrick
- K. McEvoy
- K. McEvoy
- K. Ogedegbe
- Kronowitz
- Kronowitz
- L. Mansfield
- L. Parvanta
- L. Tang
- L.J. Whisker
- L.M. Lai
- Lardi
- Lisa J. Whisker
- M. Barkeji
- M. Dickson
- M. Fawzy
- M. Galea
- M. Griffiths
- M. Mullan
- M. Rostom
- M. Youssef
- M.D. Gardiner
- Martin
- Matthew D. Gardiner
- McCarthy
- McCarthy
- Mendenhall
- N. Barnes
- N. Dunne
- N. Manoloudakis
- N. Mills
- N.L.P. Barnes
- Ng
- Nicola L.P. Barnes
- O.A. Branford
- O.S. Olyinka
- P. Mallon
- P. Turton
- P.R. Williamson
- Paula R. Williamson
- Potter
- Potter
- Potter
- R. Achuthan
- R. Brindle
- R. Foulkes
- R. Jacklin
- R. James
- R. Johnson
- R. Linforth
- R. Rathinaezhil
- R. Vidya
- R. Vinayagam
- R. Waters
- R.I. Cutress
- R.I. Cutress
- Rainsbury
- Ramsey I. Cutress
- S. Benyon
- S. Chopra
- S. Clark
- S. Down
- S. Gawne
- S. George
- S. Hignett
- S. Hignett
- S. Huf
- S. Joglekar
- S. Kirk
- S. Kohlhardt
- S. Laws
- S. Ledwidge
- S. McIntosh
- S. Mylavaganam
- S. Mylvaganam
- S. Mylvaganam
- S. Potter
- S. Potter
- S. Robertson
- S. Saha
- S. Soumian
- S. Tang
- S. Tayeh
- S. Thrush
- S. Waheed
- S.J. Cawthorn
- Salzberg
- sante Andsdmedpd
- Senthurun Mylvaganam
- Sheflan
- Shelley Potter
- Steven Thrush
- T. Collin
- T. Gangamihardja
- T. Graja
- T. Irvine
- Thiruchelvam
- V. Lefemine
- V. Muralikrishnan
- V. Voynov
- W. Sarakbi
- Wilson
- Zhong
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)