Foam-Glass Modified By Technological Nano-additive

Investigations have been conducted to study the effects of man-made nano-additive on basic physical and mechanical properties of foamed glass. As the main raw material used tare and flat glass. It was investigate the effect of nano-additive on structural features of the resulting foam glass at a temperature of 850 °C

Foam-Glass Modified By Technological Nano-additive

Investigations have been conducted to study the effects of man-made nano-additive on basic physical and mechanical properties of foamed glass. As the main raw material used tare and flat glass. It was investigate the effect of nano-additive on structural features of the resulting foam glass at a temperature of 850 °C

МОДЕРНИЗАЦИЯ ДОРОГ: ТЕХНИКО-ЭКОНОМИЧЕСКИЙ АСПЕКТ

The article analyzes some modern approaches towards solutions used to engineer and modernize railways. Net present value is deemed to be a criterion of assessment. This method allows considering the main features of the subject with greater validity. These include cargo traffic changing during the given periods, volume and dates of investments, onflow and flight of capital during the estimated period. The author has proposed a method to outline technical developments of a railway.Современные подходы к анализу решений при проектировании новых и модернизации существующих железных дорог. В качестве критерия оценки принята величина чистого дисконтированного дохода (ЧДД, NPV), что позволяет с большей достоверностью учесть все основные особенности рассматриваемого объекта: грузопоток, изменяющийся во времени, размеры и сроки реализации капиталовложений, притоки и оттоки средств в течение расчетного периода. Приведена методика формирования оптимальной схемы развития технического оснащения дороги.Современные подходы к анализу решений при проектировании новых и модернизации существующих железных дорог. В качестве критерия оценки принята величина чистого дисконтированного дохода (ЧДД, NPV), что позволяет с большей достоверностью учесть все основные особенности рассматриваемого объекта: грузопоток, изменяющийся во времени, размеры и сроки реализации капиталовложений, притоки и оттоки средств в течение расчетного периода. Приведена методика формирования оптимальной схемы развития технического оснащения дороги

Surgical ulcerative gastroduodenal bleeding in patients with pyloroduodenal stenosis

Analysis of surgical treatment of 106 patients with ulcerative gastroduodenal hemorrhage arising in the presence of pyloroduodenal stenosis of varying severity. The patients were divided into 2 groups: 50 people, made a comparison group received traditional surgical treatment, and 56 people. A group of patients who received surgical treatment developed. It is shown that the application of a rational preoperative surgicaltion election tactics and postoperative therapy with the introduction of oxygen-containing solution intraenteric improve treatment outcomes

Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia. Care delivery for HHT patients is impeded by the need for laborious, repeated phenotyping and gaps in knowledge regarding the relationships between causal DNA variants in ENG, ACVRL1, SMAD4 and GDF2, and clinical manifestations. To address this, we analyzed DNA samples from 183 previously uncharacterized, unrelated HHT and suspected HHT cases using the ThromboGenomics high-throughput sequencing platform. We identified 127 rare variants across 168 heterozygous genotypes. Applying modified American College of Medical Genetics and Genomics Guidelines, 106 variants were classified as pathogenic/likely pathogenic and 21 as nonpathogenic (variant of uncertain significance/benign). Unlike the protein products of ACVRL1 and SMAD4, the extracellular ENG amino acids are not strongly conserved. Our inferences of the functional consequences of causal variants in ENG were therefore informed by the crystal structure of endoglin. We then compared the accuracy of predictions of the causal gene blinded to the genetic data using 2 approaches: subjective clinical predictions and statistical predictions based on 8 Human Phenotype Ontology terms. Both approaches had some predictive power, but they were insufficiently accurate to be used clinically, without genetic testing. The distributions of red cell indices differed by causal gene but not sufficiently for clinical use in isolation from genetic data. We conclude that parallel sequencing of the 4 known HHT genes, multidisciplinary team review of variant calls in the context of detailed clinical information, and statistical and structural modeling improve the prognostication and treatment of HHT

Antineutrino-Deuteron Experiment at Krasnoyrsk

This report is represented the results of some experiments, which carried out at the neutrino underground laboratory of Kranoyarsk nuclear plant.Comment: 8 pages, 3 figure

The association between family and community social capital and health risk behaviours in young people: an integrative review

Background: Health risk behaviours known to result in poorer outcomes in adulthood are generally established in late childhood and adolescence. These ‘risky’ behaviours include smoking, alcohol and illicit drug use and sexual risk taking. While the role of social capital in the establishment of health risk behaviours in young people has been explored, to date, no attempt has been made to consolidate the evidence in the form of a review. Thus, this integrative review was undertaken to identify and synthesise research findings on the role and impact of family and community social capital on health risk behaviours in young people and provide a consolidated evidence base to inform multi-sectorial policy and practice.<p></p> Methods: Key electronic databases were searched (i.e. ASSIA, CINAHL, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, Embase, Medline, PsycINFO, Sociological Abstracts) for relevant studies and this was complemented by hand searching. Inclusion/exclusion criteria were applied and data was extracted from the included studies. Heterogeneity in study design and the outcomes assessed precluded meta-analysis/meta-synthesis; the results are therefore presented in narrative form.<p></p> Results: Thirty-four papers satisfied the review inclusion criteria; most were cross-sectional surveys. The majority of the studies were conducted in North America (n=25), with three being conducted in the UK. Sample sizes ranged from 61 to 98,340. The synthesised evidence demonstrates that social capital is an important construct for understanding the establishment of health risk behaviours in young people. The different elements of family and community social capital varied in terms of their saliency within each behavioural domain, with positive parent–child relations, parental monitoring, religiosity and school quality being particularly important in reducing risk.<p></p> Conclusions: This review is the first to systematically synthesise research findings about the association between social capital and health risk behaviours in young people. While providing evidence that may inform the development of interventions framed around social capital, the review also highlights key areas where further research is required to provide a fuller account of the nature and role of social capital in influencing the uptake of health risk behaviours.<p></p&gt

Validation of diagnostic accuracy using digital slides in routine histopathology

Background: Robust hardware and software tools have been developed in digital microscopy during the past years for pathologists. Reports have been advocated the reliability of digital slides in routine diagnostics. We have designed a retrospective, comparative study to evaluate the scanning properties and digital slide based diagnostic accuracy. Methods: 8 pathologists reevaluated 306 randomly selected cases from our archives. The slides were scanned with a 20 × Plan-Apochromat objective, using a 3-chip Hitachi camera, resulting 0.465 μm/pixel resolution. Slide management was supported with dedicated Data Base and Viewer software tools. Pathologists used their office PCs for evaluation and reached the digital slides via intranet connection. The diagnostic coherency and uncertainty related to digital slides and scanning quality were analyzed. Results: Good to excellent image quality of slides was recorded in 96%. In half of the critical 61 digital slides, poor image quality was related to section folds or floatings. In 88.2 % of the studied cases the digital diagnoses were in full agreement with the consensus. Out of the overall 36 incoherent cases, 7 (2.3%) were graded relevant without any recorded uncertainty by the pathologist. Excluding the non-field specific cases from each pathologist’s record this ratio was 1.76 % of all cases. Conclusions: Our results revealed that: 1) digital slide based histopathological diagnoses can be highly coherent with those using optical microscopy; 2) the competency of pathologists is a factor more important than the quality of digital slide; 3) poor digital slide quality do not endanger patient safety as these errors are recognizable by the pathologist and further actions for correction could be taken. Virtual slides: The virtual slide(s) for this article can be found here