1,317 research outputs found
A local tone mapping operator for high dynamic range images
In this paper, we present a new tonemapping operator to display high dynamic range image onto conventional displayable devices and printers. In our work, a new tone map algorithm, derived from the Contrast Limited Adaptive histogram Equalization (CLAHE) technique is presented. Due to different luminance intervals could result in overlapped reaction on the limited response in limited response range of visual system, we use scenes region splitting and merging to segment the scaled luminance, L(x, y) and perform the CLAHE in each segment with different clip limit in order to extending our visual response range to cope with the full dynamic range of high contrast. Until now, there is no fix standard of objective evaluation available to measuring the quality of displayed High Dynamic Range (HDR) images because it is difficult to know how the light or dark the image should be displayed to faithful to the original HDR image. As the result, the main evaluation is based on human's subjective evaluation. In this paper, we consider this to evaluate the performances with different tone mapping method
A new technique to reproduced high-dynamic-range images for low-dynamic-range display
Tone mapping is a process for reproduction of High-Dynamic-Range images (HDR) for Low-Dynamic-Range (LDR) output devices. In this report, author presents a new local tone-mapping operator, derived from the Contrast Limited Adaptive histogram Equalization (CLAHE) technique for displaying high dynamic range image. The CLAHE is a method which was originally developed for medical imaging. This method has effectively expanded the full dynamic range of display and it is fully automatic. Due to different luminance intervals could result in overlapped reaction on the limited response in limited response range of visual system, scene region splitting and merging were used to segment the scaled luminance and perform the image segmentation to segment image into smaller part. After the region splitting and merging, there will be some noise or variation of intensity that may result in holes or over segmentation. As the result, the morphological operation, opening and closing were used to perform the mask to applied different clip limit of the CLAHE operation
Development of CMOS imager block for capsule endoscope
This paper presents the development of imager block to be associated in a capsule endoscopy system. Since the capsule endoscope is used to diagnose gastrointestinal diseases, the imager block must be in small size which is comfortable for the patients to swallow. In this project, a small size 1.5V button battery is used as the power supply while the voltage supply requirements for other components such as microcontroller and CMOS image sensor are higher. Therefore, a voltage booster circuit is proposed to boost up the voltage supply from 1.5V to 3.3V. A low power microcontroller is used to generate control pulses for the CMOS image sensor and to convert the 8-bits parallel data output to serial data to be transmitted to the display panel. The results show that the voltage booster circuit was able to boost the voltage supply from 1.5V to 3.3V. The microcontroller precisely controls the CMOS image sensor to produce parallel data which is then serialized again by the microcontroller. The serial data is then successfully translated to 2fps image and displayed on computer
Risk factors for lower extremity deep vein thrombosis in acute stroke patients following endovascular thrombectomy: a retrospective cohort study
BackgroundDeep vein thrombosis (DVT) in lower extremities as a common complication of acute ischemic stroke (AIS) has long been studied. However, as the therapeutic options for AIS continue to advance, the pathogenic mechanisms behind DVT may change. Endovascular thrombectomy (EVT) has replaced intravenous thrombolysis and become the preferred treatment for AIS patients with large vessel occlusions. Therefore, it is important to update our understanding of DVT and its management. This study aimed to determine the prevalence and risk factors of DVT in AIS patients following EVT.MethodsIn this retrospective study, 245 AIS patients who had received EVT were recruited between January 2020 and December 2021. Within 10 days (median 4 days) of thrombectomy, DVT was diagnosed by ultrasonography. Demographic characteristics, clinical findings, and therapeutic procedures were compared between patients with and without DVT using univariate analysis. Cutoff points were defined for EVT time and plasma D-dimer concentration. Multivariable logistic regression was then used to determine the independent risk factors for DVT and evaluate their predictive power.ResultsThe prevalence of DVT in AIS patients after EVT was 27.3%. Multifactorial logistic regression analysis showed that age (OR 1.036, 95% CI 1.001–1.073; P = 0.045), female sex (OR 3.015, 95% CI 1.446–6.289; P = 0.003), lower limb muscle strength less than grade three (OR 7.015, 95% CI 1.887–26.080; P = 0.004), longer EVT time (OR 1.012, 95% CI 1.004–1.020; P = 0.003), and higher D-dimer levels (OR 1.350, 95% CI 1.150–1.585; P < 0.001) were independently associated with higher DVT risk in AIS patients following EVT. The cutoff points for operative time of EVT and plasma D-dimer were 65.5 min and 1.62 mg/L, respectively, above which the risk for DVT was dramatically increased with OR > 4 in AIS patients.ConclusionAIS patients are at increased risk of developing DVT following EVT particularly if they have undergone prolonged thrombectomy procedures and exhibit high plasma levels of D-dimers. However, the results of our study need to be validated by a multicenter prospective study with a larger population of stroke patients
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578 leading to its degradation via ubiquitylation by an E3 ligase (CNOT4). Overexpression of PRMT1 in acute megakaryocytic leukemia cell lines blocks megakaryocyte terminal differentiation by downregulation of RBM15 protein level. Restoring RBM15 protein level rescues megakaryocyte terminal differentiation blocked by PRMT1 overexpression. At the molecular level, RBM15 binds to pre-mRNA intronic regions of genes important for megakaryopoiesis such as GATA1, RUNX1, TAL1 and c-MPL. Furthermore, preferential binding of RBM15 to specific intronic regions recruits the splicing factor SF3B1 to the same sites for alternative splicing. Therefore, PRMT1 regulates alternative RNA splicing via reducing RBM15 protein concentration. Targeting PRMT1 may be a curative therapy to restore megakaryocyte differentiation for acute megakaryocytic leukemia
Experimental quantum computational chemistry with optimised unitary coupled cluster ansatz
Simulation of quantum chemistry is one of the most promising applications of
quantum computing. While recent experimental works have demonstrated the
potential of solving electronic structures with variational quantum eigensolver
(VQE), the implementations are either restricted to nonscalable (hardware
efficient) or classically simulable (Hartree-Fock) ansatz, or limited to a few
qubits with large errors for the more accurate unitary coupled cluster (UCC)
ansatz. Here, integrating experimental and theoretical advancements of improved
operations and dedicated algorithm optimisations, we demonstrate an
implementation of VQE with UCC for H_2, LiH, F_2 from 4 to 12 qubits. Combining
error mitigation, we produce high-precision results of the ground-state energy
with error suppression by around two orders of magnitude. For the first time,
we achieve chemical accuracy for H_2 at all bond distances and LiH at small
bond distances in the experiment. Our work demonstrates a feasible path towards
a scalable solution to electronic structure calculation, validating the key
technological features and identifying future challenges for this goal.Comment: 8 pages, 4 figures in the main text, and 29 pages supplementary
materials with 16 figure
JUNO Conceptual Design Report
The Jiangmen Underground Neutrino Observatory (JUNO) is proposed to determine
the neutrino mass hierarchy using an underground liquid scintillator detector.
It is located 53 km away from both Yangjiang and Taishan Nuclear Power Plants
in Guangdong, China. The experimental hall, spanning more than 50 meters, is
under a granite mountain of over 700 m overburden. Within six years of running,
the detection of reactor antineutrinos can resolve the neutrino mass hierarchy
at a confidence level of 3-4, and determine neutrino oscillation
parameters , , and to
an accuracy of better than 1%. The JUNO detector can be also used to study
terrestrial and extra-terrestrial neutrinos and new physics beyond the Standard
Model. The central detector contains 20,000 tons liquid scintillator with an
acrylic sphere of 35 m in diameter. 17,000 508-mm diameter PMTs with high
quantum efficiency provide 75% optical coverage. The current choice of
the liquid scintillator is: linear alkyl benzene (LAB) as the solvent, plus PPO
as the scintillation fluor and a wavelength-shifter (Bis-MSB). The number of
detected photoelectrons per MeV is larger than 1,100 and the energy resolution
is expected to be 3% at 1 MeV. The calibration system is designed to deploy
multiple sources to cover the entire energy range of reactor antineutrinos, and
to achieve a full-volume position coverage inside the detector. The veto system
is used for muon detection, muon induced background study and reduction. It
consists of a Water Cherenkov detector and a Top Tracker system. The readout
system, the detector control system and the offline system insure efficient and
stable data acquisition and processing.Comment: 328 pages, 211 figure
A new measurement of antineutrino oscillation with the full detector configuration at Daya Bay
We report a new measurement of electron antineutrino disappearance using the
fully-constructed Daya Bay Reactor Neutrino Experiment. The final two of eight
antineutrino detectors were installed in the summer of 2012. Including the 404
days of data collected from October 2012 to November 2013 resulted in a total
exposure of 6.910 GW-ton-days, a 3.6 times increase over
our previous results. Improvements in energy calibration limited variations
between detectors to 0.2%. Removal of six Am-C radioactive
calibration sources reduced the background by a factor of two for the detectors
in the experimental hall furthest from the reactors. Direct prediction of the
antineutrino signal in the far detectors based on the measurements in the near
detectors explicitly minimized the dependence of the measurement on models of
reactor antineutrino emission. The uncertainties in our estimates of
and were halved as a result of these
improvements. Analysis of the relative antineutrino rates and energy spectra
between detectors gave and eV in the three-neutrino
framework.Comment: Updated to match final published versio
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