A researgh on meniere disease of famillid mediterranean fever patients

FMF, Akdeniz çevresindeki toplumlarda sık olarak görülen, ateşin eşlik ettiği, periyodikperitonit, plörit, artrit, perikardit ve/veya erizipel benzeri cilt lezyonları ile karakterizeotozomal resesif bir hastalıktır. MEFV genindeki mutasyonlar tarafından oluşturulur.Meniere hastalığı ise, iç kulağın membranöz labirentinin idiyopatik bir hastalığıdır.Vertigo, tinnitus ve sensörinöral işitme kaybı ile karakterizedir. Ayrıca; kulakta dolgunlukhissi, bulantı, kusma, gibi semptomlar da görülebilmektedir. Etyoloji tam belli olmamaklabirlikte; hastalığın endolenfin hidropsuna bağlı olarak meydana geldiği gösterilmiştir.Amaç: Çalışmamızın FMF ve Meniere hastalığı arasında bir ilişkinin olup olmadığınıgöstermekdir.Gereç-Yöntem: Çalışmaya 80 FMF hastası ve 17 Meniere hastası dahil edildi. Hastalıklıkontrol grubu olarak 42 Behçet hastası ve sağlıklı 50 birey alındı.FMF, Behçet ve sağlıklı kontrol grubundan, Meniere hastalığına benzer semptomlarıtarifleyen olgulardan, gereken hastalara odiyometri yapıldı. Meniere grubundakihastalardan FMF semptomatolojisi tarifleyenler, FMF açısından değerlendirildi. AyrıcaMeniere'lilerden 12 hastaya MEFV gen mutasyonu çalışıldı.Bulgular: FMF ve Behçet hastaları arasında, Meniere semptomları (vertigo, tinnitus,kulakta basınç hissi, işitme kaybı) yönünden anlamlı farklılık tesbit edilmedi(p>0,005).FMF ve Behçet hastalarındaki Meniere semptomları, sağlıklı kontrollerlekarşılaştırıldığında; sadece FMF'li hastalardaki vertigo sıklığı % 22,5 olarak, sağlıklıkontrollerden anlamlı derecede fazla bulundu (p=0,001). Meniere'li 12 hastanın % 25'indeMEFV gen mutasyonu tesbit edildi.Sonuç: FMF ve Meniere hastalığı arasında bir ilişki olabileceğini gösteren bulgularımız,bu konuyla ilgili çalışmaların yapılması gerektiğini düşündürmektedir.Anahtar kelimeler: FMF, Meniere hastalığı, MEFV mutasyonu, odiyometriFMF is a disease which seen mostly in population living around the Mediterranean andcharacterized by periodic peritonitis, plevritis, arthritis, pericarditis and erysipelas like skinlesions together with fever and it has otosomal recesive penetration and it is caused byMEFV gene mutation.Meniere Disease (MD) is an idiopathic disease of membranouss labyrinth of inner ear.Itis characterized by vertigo, tinnitus and sensorineural deafness. In addition to them sence ofplumping on ear, nausea and vomiting may be seen. Etiology of MD is unknown butassociation with endolymph dilatation had seen shown.AİM: The aim of this study is to look if there is relationship between FMF and MD.METHOD: 80 FMF patients and 17 MD patients were recruited to the study. Weselected 42 Behcet patiens and 50 people who healthy were chosen as a control group.The participants in FMF, Behcet Disease and healthy people groups who have MDsymptoms were consultated with Otorhinolaryngology odiometric tests were performed.The MD patients who have FMF symptoms were invastigated for FMF and also MEFVmutation was studied in 12 MD patients.DISCUSSION: There was no differences between FMF and Behcet patiens respect toMD symptoms like vertigo, tinnitus, deafnes and sence of pressure on ear(p>0,005).When we compared MD symptoms FMF and BD patients groups with healthy people, wefound that FMF patients have %22,5 vertigo ratio and it was more than healthy group andmeaningful(p=0,001). Also %25 of MD patients have MEFV gene mutation.RESULTS: Because of the clues about relationship between FMF and MD whichshown our study ,more studies should be done about this subject.KEY WORDS: FMF, Meniere Disease, MEFV gene mutation, odiometry test

Digital ulcer as a rare complication of systemic lupus erythematosus: A case report

The two most common rheumatological diseases which accompany Raynauds phenomenon are systemic sclerosis and systemic lupus erythematosus (SLE). Digital gangrene formation has no definitive etiology and pathogenesis, and Raynauds phenomenon often accompanies the necrotic lesions associated with this skin condition. Macrovascular involvement is commonly found in systemic sclerosis, but is very rare in patients with SLE. In our case, we identified ulnar artery involvement in the absence of any other risk factors associated with digital gangrene formation. Raynauds phenomenon is fairly common in SLE, but digital ulcers are seldomly seen. The most common cause of digital gangrene in SLE is antiphospholipid antibody syndrome (AAS). The risk factors for digital ulcers include duration of lupus, male gender, atherosclerosis, vasculitis, and AAS. Herein, we present a case with long-standing SLE who also had digital ulcers

Upper extremity thrombosis in Behçets disease

Behçet hastalığı (BH) tekrarlayan oral, genital ülser ve göz tutulumuyla karakterize, ayrıca eklem, nörolojik, gastrointestinal sistem ve damar tutulumunun da oluşabildiği sistemik bir hastalıktır. BH de venöz tutulum arteryel tutulumdan daha fazla görülmektedir. Venöz tutulum sıklıkla alt ekstremite venlerinde meydana gelir. Üst ekstremite venlerinde tutulum ise nadirdir. Bu yazıda üst ekstremite yüzeyel ven trombozu ile gelen BH olgusundan bahsedilecektir.Behçets disease (BD) is a systemic disease characterized by oral aphthosis, genital ulcers, ocular lesions and also gastrointestinal, musculoskeletal, neurological and vessel involvements may develop. Venous manifestations are more common than arterial involvement. Venous involvement often occurs in the veins of lower extremity. Upper extremity venous involvement is rare. In this paper we report a case of BH presenting with upper extremity superficial vein thrombosis

Upper extremity thrombosis in Behçet’s disease

Behçet’s disease (BD) is a systemic disease characterizedby oral aphthosis, genital ulcers, ocular lesions andalso gastrointestinal, musculoskeletal, neurological andvessel involvements may develop. Venous manifestationsare more common than arterial involvement. Venousinvolvement often occurs in the veins of lower extremity.Upper extremity venous involvement is rare. In this paperwe report a case of BH presenting with upper extremitysuperficial vein thrombosis.Key words: Behçet’s disease, upper extremity, superficialvein thrombosi

Evaluation of knowledge on basic life support of the Afyonkarahisar Police Vocational School students

Amaç: Temel yaşam desteği (TYD), sağlıkçı olmayanlar tarafından da bilinmesi gereken, hayat kurtaran bir yakla- şımdır. Polisler genellikle sağlık ekiplerinden daha önce olay yerinde bulunmakta ve toplumsal olaylarda görev almaktadırlar. Bu çalışmanın amacı, Afyonkarahisar Polis Meslek Yüksekokulunda eğitim görmekte olan polis adaylarının TYD ile ilgili bilgi düzeylerini ölçmektir. Gereç ve Yöntem: Bu cross-sectional çalışma 269 öğrenci ile yapıldı. Verilerin toplanmasında sosyodemografik özelliklerini ve TYD uygulamaları ile ilgili bilgi düzeylerini değerlendiren 31 adet sorudan oluşan anket kullanıldı. Verilerin değerlendirmesinde tanımlayıcı istatistik kullanıldı. Bulgular: Çalışmaya katılan 269 erkek öğrencinin ortalama yaşı 20±1,6 yıl idi. Öğrencilerin % 81’i (n=218) TYD uygulamalarını bilmenin meslek hayatlarında faydalı olacağını, % 31,6 (n=85) öğrenci TYD konusunda eğitim aldığını belirtti. TYD konusunda eğitim alan 85 (% 31,6) öğrencinin 45’i (% 53,2 ) ankette yer alan TYD uygulamaları ile ilgili 14 soruyu doğru cevaplandırdı. Öğrencilerin kalp masajı ile ilgili sorulara ortalama doğru cevap verme oranı % 54,3 olarak tespit edildi. Sonuç: Polis adaylarına yönelik TYD eğitim programları geliştirilmeli, güncellenmeli, tekrarlanmalı ve bilgi, becerileri artırılarak devamlılığı sağlanmalıdır.Objective: Basic life support (BLS) is a life-saving approach that should be also known by not welfare professionals. The police teams are ready before the health teams in the events and having duties in the social events. The aim of this study is to measure the level of BLS information of the police candidates’ who are training in Afyonkarahisar Police Vocational School. Material and Methods: This cross-sectional study was performed with 269 students. For the collection of data it is used a questionnaire consisting of 31 questions evaluating socio-demographic characteristics and the level of knowledge on BLS of the students. Descriptive statistics were used for evaluation of the data. Results: The mean age of the 269 male students was 20±1,6 years. 81 % of the students (n=218) decelerated that knowing BLS practices would be useful in their professional life, 31,6 % (n=85) of them had an education on BLS. 85 students had an education on BLS, 45 (53,2 %) of them answered correctly 14 questions in the questionnaire. The average rate of correct answers to questions about students' cardiac massage was 54,3 %. Conclusion: Training on BLS for the police candidates should be improved, up to dated, repeated and continued via increasing knowledge and skill

Improving dynamic process stability in finishing of thin-walled workpieces by optimal selection of stock shape

In 5-axis milling of thin-wall parts, flexibility of the in-process-workpiece (IPW) governs static and dynamic deflections, especially at the semifinishing and finishing stages. Thus, the near net shape preform, i.e. the stock shape left for semi/finishing is crucial for chatter stability. In this study, a methodology is presented to design the stock shape for improved stability. Coupled process simulation, which includes material removal, finite element analysis (FEA) and process stability simulations, is used to show the effect of stock shape on chatter stability. Spindle speed is optimized along the toolpath based on the varying process dynamic behavior for selected cutter locations (CL). The proposed method is experimentally demonstrated on case studies

Thoracic Complications in Behçet’s Disease: Imaging Findings

Behçet’s disease (BD) causes vascular inflammation and necrosis in a wide range of organs and tissues. In the thorax, it may cause vascular complications, affecting the aorta, brachiocephalic arteries, bronchial arteries, pulmonary arteries, pulmonary veins, capillaries, and mediastinal and thoracic inlet veins. In BD, chest radiograph is commonly used for the initial assessment of pulmonary symptoms and complications and for follow-up and establishment of the response to treatment. With the advancement of helical or multislice computed tomography (CT) technologies, such noninvasive imaging techniques have been employed for the diagnosis of vascular lesions, vascular complications, and pulmonary parenchymal manifestations of BD. CT scan (especially, CT angiography) has been used to determine the presence and severity of pulmonary complications without resorting to more invasive procedures, in conjunction with gadolinium-enhanced three-dimensional (3D) gradient-echo magnetic resonance (MR) imaging with the subtraction of arterial phase images. These radiologic methods have characteristics that are complementary to each other in diagnosis of the thoracic complications in BD. 3D ultrashort echo time (UTE) MR imaging (MRI) could potentially yield superior image quality for pulmonary vessels and lung parenchyma when compared with breath-hold 3D MR angiography