Parabolik denklem için ters problem üzerine bir çalışma

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Bu çalışma diferansiyel denklemler için ters problemler teorisini matematiksel fiziğin çatısı altında kapsamlı olarak geliştirilmesinin sunulması üzerine yapılmıştır. Ters problemler teorisinin kökeni 19. yüzyılın sonlarında veya 20. yüzyılın başlarında ortaya çıkmıştır.Ters problem, ısı ve kütle transferi, potansiyel teori, nükleer fizik, esneklik teorisi, sismolojide kinematik problemler, Sturm-Liouville problemini ve daha fazlasını içermektedir.Bu çalışmada adlandırılan direkt problem, ters problem denklemi bilinmiyorken, verilen bir diferansiyel denklemin veya denklem sisteminin çözümünü ek koşullar aracılığı ile gerçekleştirilmiştir. Bu çalışmada mevcut olan parabolik denklemler, ters problemler için en yaygın olandan biridir. Ters problem belirli uygun koşullar altında ortaya çıkan çözümden yola çıkarak bize problemi vermektedir. Son olarak bu çalışmada ters problemin varlığı ve tekliği de kanıtlanmıştır.This study present the theory of inverse problems for differential equations is being extensively developed within the from work of mathematical phycis. The sources of the theory of inverse problems may be found lately in the 19th centry or early 20 th century.Inverse problems contains heat and mass transfer, potantiel theory, nuclear physics, elasticity theory, the kinematic problems in seismology, the STURM LIOUVİLLE problem and more.In the study of so-called direct problems the solution of a given differential equation or system of equatinos is realised by means of supplementary conditions, while in inverse problems the equation it self is also unkown.In this study of parabolic equation is are of the wide spread inverse problems. The inverse problems under avaliable conditions gives the problem from its solution.Finally in this study, the uniquess of solution and existence its for inverse problem is proved

Educación intercultural y programa de intercambio Erasmus: estudiantes de la Universidad de Mármara

This article aims to emphasize the importance and impact of intercultural education on the students of higher education with a specific focus on the ERASMUS Studies Exchange program through the case of Marmara University. Since its launch, ERASMUS Studies Exchange Program has attracted many students across the EU. The overall experience the students gained is not limited to academic experience but goes far beyond as cultural exchange, learning from one another, respect to diversities and increasing awareness on the issues of multiculturalism and intercultural education. Marmara University has been actively participating in the program since 2004, with increasing figures each year, in terms of both student and teaching staff exchange. Ranked as the first university in Turkey in terms of incoming student numbers and the sixth in terms of outgoing, (Turkish National Agency, 2013) the experiences of its students is thought to be important in further enhancement of and encouragement in participation to intercultural education experience. Based on the ‘ERASMUS Impact Study’ by the EU Commission, the case of Marmara University students is analyzed with a descriptive study.El presente artículo tiene como objetivo subrayar la importancia y el impacto de la educación intercultural en los estudiantes de educación superior, prestando una especial atención al Programa de Intercambio ERASMUS en la Universidad de Mármara (Estambul, Turquía). Desde su lanzamiento, el Programa de Intercambio ERASMUS ha atraído a un gran número de estudiantes procedentes de distintos países de la UE. La experiencia que los estudiantes han obtenido no se limita al ámbito académico, sino que va más allá, como intercambio cultural, aprendizaje del otro, respeto a la diversidad y una mayor sensibilidad acerca de aspectos relacionados con la multiculturalidad y la educación intercultural. La Universidad de Mármara participa activamente en el programa desde 2004 y las cifras, tanto de intercambio de alumnos como de profesorado, sigue aumentando año tras año. Considerada como la primera universidad de Turquía en términos de recepción de estudiantes extranjeros y la sexta en cuanto a alumnos que viajan a otros países en el programa según la Agencia Nacional Turca (2013), se considera que las experiencias de sus estudiantes resultan fundamentales para fomentar y mejorar su participación en experiencias educativas interculturales. De acuerdo con el “ERASMUS Impact Study” de la Comisión Europea, el caso de la Universidad de Mármara se analiza aquí mediante un estudio descriptivo

Clinical Study Effects of Zoledronate on Mortality and Morbidity after Surgical Treatment of Hip Fractures

We aimed to evaluate the effects of intertrochanteric femoral fractures on mortality, morbidity, and cost of zoledronate treatment in elderly patients treated by osteosynthesis. Based on Evans classification, 114 patients with unstable intertrochanteric femoral fractures were treated with osteosynthesis. After the surgical treatment of intertrochanteric fractures, the treatment group (M/F, 24/32; mean age, 76.7 ± SD years) received zoledronate infusion, and the control group (M/F, 20/38; mean age, 80.2 ± SD years) received placebo. Postoperative control visits were performed at 6-week, 3-month, 6-month, and 12-month time points. Functional level of patients was evaluated by the modified Harris hip score and Merle d' Aubigné hip score. By 12 months, the mean HHS in treatment and control groups was 81.93 and 72.9, respectively. For time of death of the patients, mortality was found to be 57.1% (16/28) on the first 3 months and 92.9% (26/28) on the first six months. The mortality rate in the treatment and control groups was 14.3% (8/56) and 34.5% (20/58), respectively. The use of zoledronic acid after surgical treatment of intertrochanteric femoral fractures in osteoporotic elderly patients is a safe treatment modality which helps to reduce mortality, improves functional outcomes, and has less side effects with single dose use per year

Clinical significance and prognostic value of serum autoantibody tests in multiple sclerosis

Introduction. It is known that multiple sclerosis (MS) often coexists with other autoimmune diseases. Hence, autoantibody (auto-Ab) tests may prove useful in the differential diagnosis of MS. The objectives of this study were to: (a) investigate the prevalence of auto-Ab positivity at the beginning of the MS diagnostic process; (b) assess whether Auto-Ab+ and Auto-Ab- patients differ in baseline clinical, laboratory, and radiological parameters; and (c) investigate the prognostic value during a two-year follow-up period. Material and methods. This retrospective study consisted of 450 patients aged between 18 and 55 years. All patients underwent a wide range of auto-Ab tests, anti-nuclear antibody (ANA) tests in particular. The expanded disability status scale (EDSS) scores of the patients were recorded at the time of diagnosis and at the end of a two-year follow-up period. Results. The mean age of the 212 patients, 148 (69.8%) female and 64 (30.2%) male, included in the study sample was 37 ± 10.83 years. The rate of relapsing cases was 84% (178). Oligoclonal band (OCB) was positive in 142 (86.6%) of the 164 tested cases. At least one of the auto-Ab tests was positive in 51 (24.1%) of the cases. ANA test was positive in 21 (9.9%) cases. There was no significant difference between patients with at least one positive auto-Ab test and without any positive auto-Ab test and between ANA-positive and ANA-negative patients in terms of age, gender, clinical features of MS, presence of brain stem lesion, presence of spinal lesion, OCB positivity, level of clinical improvement after the first pulse steroid treatment, family history, presence of comorbidity, presence of autoimmune disease, or EDSS scores recorded at the end of the two-year follow-up period (p > 0.05). Conclusions. Our study findings revealed that Auto-Ab positivity was more common in MS patients than in the general population. However, given their limited contribution to the diagnosis and differential diagnosis of MS with no effect on the prognostic process, auto-Ab tests should be requested only in the event of accompanying autoimmune disease symptoms, and in cases where the diagnosis of MS may be suspected

Laboratuvardan Kliniğe Transplantasyon Pratiği

Transplantasyon; Temel Tıbbi Bilimler, Moleküler Tıp, Genetik ve İmmünolojiden klinik uygulamalardan destek alan multidisipliner bir tıp dalıdır. Temel bilimlerdeki başarılı çalışmaların kliniğe uygulanması, klinikte karşılaşılan sorunların da, oluşturulan deneysel hayvan modellerinde irdelenmesi, elde edilen bilgilerin klinik uygulamalara aktarılması; diğer deyişle tecrübelerin “Translational” özellikli olması günümüz transplantasyon çalışmalarında bir gerekliliktir. İmmün sistemin bileşenlerinin ve reaksiyonlarının iyi bilinmesi, hücreler arası ilişkilerde greftin reddi ya da kabul edilmesinin şartlarını doğru anlamak ve uygun laboratuvar yöntemleri ile klinik durumun aydınlatılması transplantasyonda stratejik önemdedir. Bu nedenle, klinik transplantasyon çalışmaları yapanlar temel bilimler bilgileri ile de donanımlı olmalıdırlar. Multidisipliner bir dal olma bilinci ile yapılan klinik transplantasyon çalışmalarında başarı yakalanmaktadır. Laboratuvardan Kliniğe Transplantasyon kitabımızda tüm yönleri ile transplantasyonun organizmaya etkileri ve bunların klinik sonuçlarını, çalışmalarımızın ışığında sunmayı ve tartışmayı hedefledik. Editör: Prof.Dr. Mesut İzzet TİTİZ Yardımcı Editör: Doç.Dr. Pınar AT

Effects of zoledronate on mortality and morbidity after surgical treatment of hip fractures

We aimed to evaluate the effects of intertrochanteric femoral fractures on mortality, morbidity, and cost of zoledronate treatment in elderly patients treated by osteosynthesis. Based on Evans classification, 114 patients with unstable intertrochanteric femoral fractures were treated with osteosynthesis. After the surgical treatment of intertrochanteric fractures, the treatment group (M/F, 24/32; mean age, 76.7 ± SD years) received zoledronate infusion, and the control group (M/F, 20/38; mean age, 80.2 ± SD years) received placebo. Postoperative control visits were performed at 6-week, 3-month, 6-month, and 12-month time points. Functional level of patients was evaluated by the modified Harris hip score and Merle d'Aubigné hip score. By 12 months, the mean HHS in treatment and control groups was 81.93 and 72.9, respectively. For time of death of the patients, mortality was found to be 57.1% (16/28) on the first 3 months and 92.9% (26/28) on the first six months. The mortality rate in the treatment and control groups was 14.3% (8/56) and 34.5% (20/58), respectively. The use of zoledronic acid after surgical treatment of intertrochanteric femoral fractures in osteoporotic elderly patients is a safe treatment modality which helps to reduce mortality, improves functional outcomes, and has less side effects with single dose use per year

Unexpected radiation pneumonitis after SIRT with significant decrease in DLCO with internal radiation exposure: a case report

Background In the last years, Selective Internal Radiation Therapy (SIRT), using biocompatible Yttrium-90 (90Y) labeled microspheres have emerged for the treatment of malignant hepatic tumors. Unfortunately, a significant part of 90Y-labeled microspheres may shunt to the lungs after intraarterial injection. It can be predictable by infusing technetium-99 m-labeled macro-aggregated albumin particles through a catheter placed in the proper hepatic artery depending on the lobe to be treated with performing a quantitative lung scintigraphy. Radiation pneumonitis (RP) can occur 1 to 6 months after the therapy, which is a rare but severe complication of SIRT. Prompt timing of steroid treatment is important due to its high mortality rate. On the other hand, pulmonary diffusion capacity measured by carbon monoxide (DLCO) is an excellent way to measure the diffusing capacity because carbon monoxide is present in minimal amount in venous blood and binds to hemoglobin in the same manner as oxygen. Some authors reported that the most consistent changes after radiation therapy (RT) are recorded with this quantitative reproducible test. The relationship between the proportional reductions in DLCO and the severity of RP developing after this therapy may prove to be clinically significant. Case presentation We herein present a patient who developed RP after SIRT that could be quantified using DLCO. To the best of our knowledge, this case is the first who developed unexpected RP after SIRT with significant decrease in DLCO with internal radiation exposure. Conclusions RP is a very rare complication and may lead to a fatal outcome. Decline in DLCO could be a valuable parameter for follow-up and to identify potential candidates for RP and could be also another trigger for administration of steroid therapy with prompt timing in this patient group

Evaluation of knowledge on basic life support of the Afyonkarahisar Police Vocational School students

Amaç: Temel yaşam desteği (TYD), sağlıkçı olmayanlar tarafından da bilinmesi gereken, hayat kurtaran bir yakla- şımdır. Polisler genellikle sağlık ekiplerinden daha önce olay yerinde bulunmakta ve toplumsal olaylarda görev almaktadırlar. Bu çalışmanın amacı, Afyonkarahisar Polis Meslek Yüksekokulunda eğitim görmekte olan polis adaylarının TYD ile ilgili bilgi düzeylerini ölçmektir. Gereç ve Yöntem: Bu cross-sectional çalışma 269 öğrenci ile yapıldı. Verilerin toplanmasında sosyodemografik özelliklerini ve TYD uygulamaları ile ilgili bilgi düzeylerini değerlendiren 31 adet sorudan oluşan anket kullanıldı. Verilerin değerlendirmesinde tanımlayıcı istatistik kullanıldı. Bulgular: Çalışmaya katılan 269 erkek öğrencinin ortalama yaşı 20±1,6 yıl idi. Öğrencilerin % 81’i (n=218) TYD uygulamalarını bilmenin meslek hayatlarında faydalı olacağını, % 31,6 (n=85) öğrenci TYD konusunda eğitim aldığını belirtti. TYD konusunda eğitim alan 85 (% 31,6) öğrencinin 45’i (% 53,2 ) ankette yer alan TYD uygulamaları ile ilgili 14 soruyu doğru cevaplandırdı. Öğrencilerin kalp masajı ile ilgili sorulara ortalama doğru cevap verme oranı % 54,3 olarak tespit edildi. Sonuç: Polis adaylarına yönelik TYD eğitim programları geliştirilmeli, güncellenmeli, tekrarlanmalı ve bilgi, becerileri artırılarak devamlılığı sağlanmalıdır.Objective: Basic life support (BLS) is a life-saving approach that should be also known by not welfare professionals. The police teams are ready before the health teams in the events and having duties in the social events. The aim of this study is to measure the level of BLS information of the police candidates’ who are training in Afyonkarahisar Police Vocational School. Material and Methods: This cross-sectional study was performed with 269 students. For the collection of data it is used a questionnaire consisting of 31 questions evaluating socio-demographic characteristics and the level of knowledge on BLS of the students. Descriptive statistics were used for evaluation of the data. Results: The mean age of the 269 male students was 20±1,6 years. 81 % of the students (n=218) decelerated that knowing BLS practices would be useful in their professional life, 31,6 % (n=85) of them had an education on BLS. 85 students had an education on BLS, 45 (53,2 %) of them answered correctly 14 questions in the questionnaire. The average rate of correct answers to questions about students' cardiac massage was 54,3 %. Conclusion: Training on BLS for the police candidates should be improved, up to dated, repeated and continued via increasing knowledge and skill

Cerebral Sinovenous Thrombosis Mimicking Intracranial Mass

 « J’ai été quant à moi productiviste… hier » (p. 68). Autant dire qu’il ne l’est plus, que l’agriculture doit avoir d’autres ambitions et que le problème concerne la société globale. « Il s’agit d’inventer une civilisation qui, mêlant les avantages de la ville et ceux de la campagne, serait faite de la synergie d’une agriculture paysanne modernisée et d’une société se développant en milieu rural. Rien de moins » (p. 187). L’ambition est grande en effet, et se heurte à de nombreux obstacles q..