THE STATE AND PROSPECTS OF DEVELOPMENT OF OILFIELD SERVICES MARKET IN RUSSIA

The article presents the assessment and results of researching of prospects of development of the Russian oilfield services market and Russian oilfield services companies. The analysis of the needs of the oil and gas sector in oilfield services is made. The authors consider the structure and volume of Russian market of services in oil and gas industry. Within the scope of this article the authors highlight the main problems of the oil service industry in Russia

THE STATE AND PROSPECTS OF DEVELOPMENT OF OILFIELD SERVICES MARKET IN RUSSIA

The article presents the assessment and results of researching of prospects of development of the Russian oilfield services market and Russian oilfield services companies. The analysis of the needs of the oil and gas sector in oilfield services is made. The authors consider the structure and volume of Russian market of services in oil and gas industry. Within the scope of this article the authors highlight the main problems of the oil service industry in Russia

Fullerene Chemistry: a New Reaction for the Synthesis of Perspective Semiconductor Materials for Organic Electronics

This work was financially supported by Russian Foundation for Basic Research (Project № 17-03-00120) and Russian Science Foundation (Project № 18-73-00084)

Hybrid Molecules Based on Fullerene C60 and Spiropyrans – Perspective Chemo- and Photosensors

This work was fulfilled within the budget topic (AAAA-A17-117012610065-2), and was financially supported by the Ministry of Education and Science of Russian Federation (Project № МК-3058.2018.3, NSh-5240.2018.3)

Molecular Design of New Hybrid Systems Based on Fullerenes and Norbornadienes

This work was fulfilled within the budget topic (AAAA-A17-117012610065-2), and financially supported by Russian Foundation for Basic Research (Project № 17-03-00120)

Technology of the photobiostimulation of the brain’s drainage system during sleep for improvement of learning and memory in male mice

In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation in the peripheral lymphatics, we demonstrate stronger effects of photobiomodulation (PBM) on the brain’s drainage system in sleeping vs. awake animals. Using the Pavlovian instrumental transfer probe and the 2-objects-location test, we found that the 10-day course of PBM during sleep vs. wakefulness promotes improved learning and spatial memory in mice. For the first time, we present the technology for PBM under electroencephalographic (EEG) control that incorporates modern state of the art facilities of optoelectronics and biopotential detection and that can be built of relatively cheap and commercially available components. These findings open a new niche in the development of smart technologies for phototherapy of brain diseases during sleep

Different Effects of Phototherapy for Rat Glioma during Sleep and Wakefulness

There is an association between sleep quality and glioma-specific outcomes, including survival. The critical role of sleep in survival among subjects with glioma may be due to sleep-induced activation of brain drainage (BD), that is dramatically suppressed in subjects with glioma. Emerging evidence demonstrates that photobiomodulation (PBM) is an effective technology for both the stimulation of BD and as an add-on therapy for glioma. Emerging evidence suggests that PBM during sleep stimulates BD more strongly than when awake. In this study on male Wistar rats, we clearly demonstrate that the PBM course during sleep vs. when awake more effectively suppresses glioma growth and increases survival compared with the control. The study of the mechanisms of this phenomenon revealed stronger effects of the PBM course in sleeping vs. awake rats on the stimulation of BD and an immune response against glioma, including an increase in the number of CD8+ in glioma cells, activation of apoptosis, and blockage of the proliferation of glioma cells. Our new technology for sleep-phototherapy opens a new strategy to improve the quality of medical care for patients with brain cancer, using promising smart-sleep and non-invasive approaches of glioma treatment.Russian Science FoundationPeer Reviewe

Machine Learning Technology for EEG-Forecast of the Blood–Brain Barrier Leakage and the Activation of the Brain’s Drainage System during Isoflurane Anesthesia

Anesthesia enables the painless performance of complex surgical procedures. However, the effects of anesthesia on the brain may not be limited only by its duration. Also, anesthetic agents may cause long-lasting changes in the brain. There is growing evidence that anesthesia can disrupt the integrity of the blood–brain barrier (BBB), leading to neuroinflammation and neurotoxicity. However, there are no widely used methods for real-time BBB monitoring during surgery. The development of technologies for an express diagnosis of the opening of the BBB (OBBB) is a challenge for reducing post-surgical/anesthesia consequences. In this study on male rats, we demonstrate a successful application of machine learning technology, such as artificial neural networks (ANNs), to recognize the OBBB induced by isoflurane, which is widely used in surgery. The ANNs were trained on our previously presented data obtained on the sound-induced OBBB with an 85% testing accuracy. Using an optical and nonlinear analysis of the OBBB, we found that 1% isoflurane does not induce any changes in the BBB, while 4% isoflurane caused significant BBB leakage in all tested rats. Both 1% and 4% isoflurane stimulate the brain’s drainage system (BDS) in a dose-related manner. We show that ANNs can recognize the OBBB induced by 4% isoflurane in 57% of rats and BDS activation induced by 1% isoflurane in 81% of rats. These results open new perspectives for the development of clinically significant bedside technologies for EEG-monitoring of OBBB and BDS.Russian Science FoundationRussian Ministry of Science and High EducationFirst Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)research center “SYMBIOSIS”Peer Reviewe