Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia

Conclusion: The obtained data indicate that the AVP level was higher, but OXT and ANP levels were lower in the patients having acute schizophrenia. Specifically OXT is related with reduced disease severity and increased functionality

New Co(II) and Cu(II) Phthalocyanine Catalysts Reinforced by Long Alkyl Chains for the Degradation of Organic Pollutants

Caglar, Yasemin/0000-0001-8462-0925WOS: 000401466600020The need to develop sustainable, low-cost, earth abundant catalyst is becoming paramount for overcoming environmental problems. Toward this goal, new cobalt(II) and copper(II) phthalocyanine complexes used as catalyst for degradation of organic pollutants (such as 2,3-dichlorophenol, 4-methoxyphenol, 4-nitrophenol, 2,3,6-trimethylphenol) with different oxygen source. This catalytic system with these complexes showed high conversion rates for degradation of organic pollutants and could easily be recovered by recycling reactions.Research Fund of Karadeniz Technical University, Trabzon-TurkeyKaradeniz Teknik University [5369]This study was supported by the Research Fund of Karadeniz Technical University, (Project no: 5369), Trabzon-Turkey

Synthesis, structural characterization, catalytic activity on aerobic oxidation of novel Co(II) and Fe(II) phthalocyanines and computational studies of 4-[2-(2,3-dichlorophenoxy)ethoxy]phthalonitrile

Caglar, Yasemin/0000-0001-8462-0925WOS: 0003748344000044-[2-(2,3-dichlorophenoxy)ethoxy] substituted Co(II) and Fe(II) phthalocyanines were successfully synthesized and characterized by the spectroscopic methods (IR, H-1 NMR, UV-Vis, mass spectrometry and elemental analysis). Determination of the optimal conditions for oxidation of phenolic compounds, the catalytic reactions were carried out change the reaction temperature, time and different oxidants, subst./cat. ratio. In the presence of phthalocyanine derivatives 4 and 5, we demonstrated that phenolic compounds oxidize to the less harmfull products with high conversion and yield. Additionally, the computational studies of 4-[2-(2,3-dichlorophenoxy) ethoxy]phthalonitrile were done in this work. (C) 2016 Elsevier B.V. All rights reserved.Research Fund of Karadeniz Technical University (Trabzon-Turkey)Karadeniz Teknik University [5302]This study was supported by the Research Fund of Karadeniz Technical University, Project no: 5302 (Trabzon-Turkey)

Anthracene Substituted Co (II) and Cu (II) phthalocyanines; Preparations, Investigation of Catalytical and Electrochemical Behaviors

Biyiklioglu, Zekeriya/0000-0001-5138-214X; Caglar, Yasemin/0000-0001-8462-0925WOS: 000441870500016An approach to investigation of catalytical behaviors of Co (II) and Cu (II) phthalocyanines is reported that is based on changing any parameter to effect these behaviors. Towards this end, new anthracene substituted Co (II) and Cu (II) phthalocyanines were prepared and characterized spectroscopic methods. New cobalt (II) and copper (II) phthalocyanines were used as catalyst for oxidation of different phenolic compounds (such as 2,3-dichlorophenol, 4-methoxyphenol, 4-nitrophenol, 2,3,6-trimethylphenol) with different oxidants. Then, electrochemical characterization of cobalt (H) and copper (II) phthallocyanines were determined by using cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. Although copper (II) phthalocyanine showed similar Pc based electron transfer processes, cobalt (II) phthalocyanine showed metal and ligand based reduction reactions as expected.Research Fund of Karadeniz Technical University [5302]Research Fund of Karadeniz Technical University, Grant/Award Number: 530

Hemodynamic Effects of Levosimendan on Dexmedetomidine Infusion in Rats Under Isoflurane Anesthesia

Objective: In this study, hemodynamic effects of levosimendan (L) on dexmedetomidine (D) infusion in rats were investigated under isoflurane (I) anesthesia. Material and Methods: A total of eighteen female Wistar-Albino rats were divided into 3 groups. Rats were artificially respirated following cannulation and tracheostomy. At the end of the stabilization period (15 min), initial hemodynamic values were recorded and (i) 1(1.4%) was administered to Group I; (ii) 1(1.4%) and D (1 mu g/kg/dk) were administered to Group ID and (iii) 1 (1.4%), D (1 mu g/kg/dk) and L (0.3 mu g/kg/dk) were administered to Group IDL for 60 min. Heart rate (HR)(bpm), systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP) (mmHg) were recorded with 5 min intervals were and given as mean and/or %. One way variance analysis, Tukey-Kramer and paired t tests were used, p<0.05 was considered the level of significance. Results: No difference was found between groups in terms of initial hemodynamic values. On the contrary, significant differences were found in HR (p=0.03) and DAP (p=0.03) at the end of the infusion period between groups. The differences were correlated to the lower HR in Group ID (176) compared to Group 1(237), (p<0.05) and a higher DAP in Group IDL (67) compared to Group 1(48), (p<0.05). In in-group comparisons; SAP (80 vs. 71 [90%], p=0.03), DAP (59 vs. 48 [81%] p=0.049), MAP (69 vs. 57 [83%], p=0.03) decreased significantly in Group I and HR (206 vs. 176 [85%], p=0.008) decreased significantly in Group ID at the end of the infusion period when compared to baseline values. Conclusion: In rats, I led to a decrease in systemic arterial pressure; and Din the presence of I led to a decrease in HR. Isoflurane-related systemic arterial pressure decrease was prevented by using of D and combination of D and L. Additionally, D-related HR decrease in the presence of I was prevented by using L. In this study, positive effects of D and DL utilization were observed when systemic arterial pressure dropped due to I. Besides, positive effect of L utilization was observed when HR decreased due to D in the presence of I in rats

Anesthetic Techniques in Octogenarians and Older Undergoing Orthopedic Surgery for Hip Fracture

Objectives: Hip fracture is common orthopedic problems for patients aged 80 years and older. Because of their decreased cardiopulmonary capacity, an optimal anesthetic technique should be chosen by anesthesiologists. The purpose of the present study is to analyze anesthetic techniques and related postoperative mortality in octogenarians and older who underwent hip fractures surgery. Patients and Methods: We analyzed hip fracture surgeries and identified patients aged 80 years and older between January 2012 and December 2013. Patient age, gender, coexisting diseases, American Society of Anesthesiologists (ASA) Physical Status classification, anesthetic technique, hematocrit, hemoglobin, total lymphocyte count (TLC), the length of surgery, intraoperative blood transfusion requirements, postoperative discharge ward, the length of postoperative hospital stay, and postoperative status were recorded. Results: We retrospectively identified 106 patients aged 80 years and older underwent hip fracture surgeries. Six (5.6%), 36 (34.0%), 2 (1.9%), 53 (50.0%), and 9 (8.5%) of procedures were performed under general anesthesia (GA), spinal anesthesia (SA), epidural anesthesia, combined spinal-epidural anesthesia (CSEA), and peripheral nerve block (PNB), respectively. The postoperative 7 and 30-day mortality were 6.6% and 10.4%, respectively. Age, gender, ASA, hematocrit, hemoglobin, TLC, discharge to the ward, the length of postoperative hospital stay, and the postoperative mortality rates were similar between the GA, SA, CSEA, and PNB. There was no relationship between postoperative mortality and anesthetic technique. Conclusion: In octogenarians and older, the postoperative mortality is higher after hip fracture and is not associated with the anesthetic technique

Eolianite and coquinite as evidence of MIS 6 and 5, NW Black Sea coast, Turkey

This paper discusses the implications of a lowstand carbonate eolianite and overlying transgressive sequence of coquinite at Sile on the Turkish Black Sea coast based on composition, depositional characteristics and optical age estimations. The cross-bedded eolianite is a mixed ooid quartz grainstone in composition, yielding a depositional age matching MIS 6. It formed at the backshore of the paleobeach with the supply of sediment the from the beach face and offering insights into the drift of mixed shallow marine carbonates and siliciclastics together with radial ooids by onshore winds from a subaerially exposed high- to low-energy ooid shoals and oolitic sand complexes which developed parallel to the shoreline on the shallow shelf margin. During this lowstand, a low-relief dune retaining a record of opposing paleowind directions than that of prevalent northeasterly winds of today appears to have been lithified to form dune rock (aeolinite) under drier conditions compared to the present. Coinciding with MIS 5e, shallow marine coquina beds resting unconformably on the eolianite indicate the occurrence of the Mediterranean transgression during the last interglacial, as confirmed by benthic foraminifera within the high-salinity tolerant coquina shells. (C) 2017 Elsevier B.V. All rights reserved

The safety and efficacy of first-line atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter real-world study from Turkey

The aim of the study was to evaluate the real-world clinical outcomes of atezolizumab and bevacizumab (Atez/Bev) as the initial therapy for advanced hepatocellular carcinoma (HCC). We retrospectively analyzed 65 patients treated with Atez/Bev for advanced HCC from 22 institutions in Turkey between September 2020 and March 2023. Responses were evaluated by RECIST v1.1 criteria. The median progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method. Cox regression model was employed to conduct multivariate analyses. The median age was 65 (range, 22-89) years, and 83.1% of the patients were male. A total of 1.5% achieved a complete response, 35.4% had a partial response, 36.9% had stable disease, and 26.2% had progressive disease. The disease control rate was 73.8% and associated with alpha-fetoprotein levels at diagnosis and concomitant antibiotic use. The incidence rates of any grade and grade ≥ 3 adverse events were 29.2% and 10.7%, respectively. At a median follow-up of 11.3 (3.4-33.3) months, the median PFS and OS were 5.1 (95% CI: 3-7.3) and 18.1 (95% CI: 6.2-29.9) months, respectively. In univariate analyses, ECOG-PS ≥ 1 (relative to 0), Child-Pugh class B (relative to A), neutrophil-to-lymphocyte ratio (NLR) > 2.9 (relative to ≤ 2.9), and concomitant antibiotic use significantly increased the overall risk of mortality. Multivariate analysis revealed that ECOG-PS ≥ 1 (HR: 2.69, P = .02), NLR > 2.9 (HR: 2.94, P = .017), and concomitant antibiotic use (HR: 4.18, P = .003) were independent predictors of OS. Atez/Bev is an effective and safe first-line therapy for advanced-stage HCC in a real-world setting. The survival benefit was especially promising in patients with a ECOG-PS score of 0, Child-Pugh class A, lower NLR, and patients who were not exposed to antibiotics during the treatment