Resting-state functional connectivity following a single dose treatment with CB1 neutral antagonist tetrahydrocannabivarin (THCv) in healthy volunteers

BACKGROUND: The cannabinoid cannabinoid type 1 (CB1) neutral antagonist tetrahydrocannabivarin (THCv) has been suggested as a possible treatment for obesity, but without the depressogenic side-effects of inverse antagonists such as Rimonabant. However, how THCv might affect the resting state functional connectivity of the human brain is as yet unknown. METHOD: We examined the effects of a single 10mg oral dose of THCv and placebo in 20 healthy volunteers in a randomized, within-subject, double-blind design. Using resting state functional magnetic resonance imaging and seed-based connectivity analyses, we selected the amygdala, insula, orbitofrontal cortex, and dorsal medial prefrontal cortex (dmPFC) as regions of interest. Mood and subjective experience were also measured before and after drug administration using self-report scales. RESULTS: Our results revealed, as expected, no significant differences in the subjective experience with a single dose of THCv. However, we found reduced resting state functional connectivity between the amygdala seed region and the default mode network and increased resting state functional connectivity between the amygdala seed region and the dorsal anterior cingulate cortex and between the dmPFC seed region and the inferior frontal gyrus/medial frontal gyrus. We also found a positive correlation under placebo for the amygdala-precuneus connectivity with the body mass index, although this correlation was not apparent under THCv. CONCLUSION: Our findings are the first to show that treatment with the CB1 neutral antagonist THCv decreases resting state functional connectivity in the default mode network and increases connectivity in the cognitive control network and dorsal visual stream network. This effect profile suggests possible therapeutic activity of THCv for obesity, where functional connectivity has been found to be altered in these regions

Neural signals of “intensity” but not “wanting” or “liking” of rewards may be trait markers for depression

We have shown previously that particpants “at risk” of depression have decreased neural processing of reward suggesting this might be a neural biomarker for depression. However, how the neural signal related to subjective experiences of reward (wanting, liking, intensity) might differ as trait markers for depression, is as yet unknown. Using SPM8 parametric modulation analysis the neural signal related to the subjective report of wanting, liking and intensity was compared between 25 young people with a biological parent with depression (FH) and 25 age/gender matched controls. In a second study the neural signal related to the subjective report of wanting, liking and intensity was compared between 13 unmedicated recovered depressed (RD) patients and 14 healthy age/gender matched controls. The analysis revealed differences in the neural signal for wanting, liking and intensity ratings in the ventral striatum, dmPFC and caudate respectively in the RD group compared to controls . Despite no differences in the FH groups neural signal for wanting and liking there was a difference in the neural signal for intensity ratings in the dACC and anterior insula compared to controls. These results suggest that the neural substrates tracking the intensity but not the wanting or liking for rewards and punishers might be a trait marker for depression

Conceptions of US and Brazilian early childhood care and education: A historical and comparative analysis

Children's first years of life are fundamental for healthy development. Appropriate care and education in the early years are far more useful than dealing with later problems, and in both the United States and Brazil scholars and public-policy makers have argued that the goal should be an integrated system of care and education. Using a cultural—historical framework to understand early childhood policies in the United States and Brazil, we examine how notions of care and education have changed over time. We show that although the two societies have the same goal, the approaches to realizing that goal have been, for historical reasons, quite different. Moreover, despite a rapid growth in the numbers of children attending preschool institutions, integrated systems have not been accomplished. Our analysis also shows how the legacy of a dichotomous approach in both societies has impeded the integration of care and education into a single system

Los Deseos y la Expresión de la Gratitud en los Jóvenes

Poucos estudos examinaram o desenvolvimento da gratidão em jovens, e nenhum estabeleceu relações entre sua gratidão e seus desejos. Assim, solicitamos a 358 participantes norte-americanos entre 7 e 14 anos de idade (56% meninas; 55% brancos) que escrevessem qual seria o seu maior desejo e o que eles fariam a seu benfeitor. Utilizando qui quadrado e estimativa de curva linear, encontramos que os mais jovens (de 7 a 10 anos de idade) foram significativamente mais propensos a expressar desejos hedonistas (desejo por ganho imediato) e gratidão concreta (não considerando os desejos do benfeitor); os jovens mais velhos (de 11 a 14 anos de idade) foram significativamente mais propensos a desejar seja algo envolvendo bem-estar futuro para si mesmos seja o bem-estar de outros e gratidão conectiva (levando em conta os desejos do benfeitor).Em ambos os grupos etários, houve uma relação inversa significativa entre desejos hedonistas e gratidão conectiva.Esta pesquisa tem implicações para encorajar o sentimento e a expressão de gratidão conectiva.Little research has examined the development of gratitude in youth, and none has related their gratitude to their wishes. We therefore asked 358 7- to 14-year-old North American participants (56% female; 55% White) to write their greatest wish and what they would do for their benefactor. Using chi-square and linear curve estimation, we found that younger youth (aged 7 to 10) were significantly more likely to express hedonistic wishes (desire for immediate gain) and concrete gratitude (not taking the benefactor's wishes into account); older youth (aged 11 to 14) were significantly more likely to wish either for something involving future well-being for themselves or the well-being of others and connective gratitude (taking into account the benefactor's wishes). Within both age groups, there was a significant inverse relation between hedonistic wishes and connective gratitude. This research has implications for encouraging the feeling and expression of connective gratitude.Pocos estudios han examinado el desarrollo de gratitud en los jóvenes, y ninguno ha relacionado su gratitud a sus deseos. Por lo tanto, pedimos a 358 participantes de América del Norte de 7 a 14 años de edad (55% femenino, 55% blanco) a escribir su mayor deseo y lo que harían por su benefactor. Utilizando un distribución ji-cuadrado y estimación curva lineal, encontramos que los más jóvenes (de 7 a 10 años de edad) fueron significativamente más propensos a expresar los deseos hedonistas (deseo de ganancia inmediata) y la gratitud de concreto (no tomar los deseos del benefactor en cuenta); los jóvenes mayores (de 11 a 14 años de edad) fueron significativamente más propensos a desear sea para algo relacionado con el bienestar futuro para sí mismos o para el bienestar de los demás y gratitud conectivo (tomando en cuenta los deseos del benefactor). Dentro de ambos grupos de edad, existe una relación inversa significativa entre los deseos hedonistas y gratitud conectivo. Esta investigación tiene implicaciones para fomentar el sentimiento y la expresión de gratitud conectivo

Young children engaging with technologies at home: the influence of family context

This paper is about with the ways in which young children engage with technological toys and resources at home and, in particular, the ways in which the family context makes a difference to young children’s engagement with these technologies. The data reviewed come from family interviews and parent-recorded video of four case study children as they used specific resources: a screen-based games console designed for family use, a technology-mediated reading scheme, a child’s games console and two technological ‘pets’. We found the same repertoire of direct pedagogical actions across the families when they supported their children’s use of the resources, yet the evidence makes it clear that the child’s experience was different in each home. The paper goes on to present evidence that four dimensions of family context made a difference to children’s engagement with technological toys and resources at home. We argue that understanding children’s experiences with technologies at home necessitates finding out about the distinct family contexts in which they engage with the resources

Rank Statistics in Biological Evolution

We present a statistical analysis of biological evolution processes. Specifically, we study the stochastic replication-mutation-death model where the population of a species may grow or shrink by birth or death, respectively, and additionally, mutations lead to the creation of new species. We rank the various species by the chronological order by which they originate. The average population N_k of the kth species decays algebraically with rank, N_k ~ M^{mu} k^{-mu}, where M is the average total population. The characteristic exponent mu=(alpha-gamma)/(alpha+beta-gamma)$ depends on alpha, beta, and gamma, the replication, mutation, and death rates. Furthermore, the average population P_k of all descendants of the kth species has a universal algebraic behavior, P_k ~ M/k.Comment: 4 pages, 3 figure

Exploring the quotidian in young children's lives at home

The challenges of conducting research in the home, especially with preschool children, mean that the role of the home as a site for research is often overlooked by educationalists. Our repeat visits to fourteen families that included a three- or four-year-old child over more than a year as part of our study “Young Children Learning with Toys and Technology at Home” enabled us to develop research relationships that resulted in a 100 percent retention rate. We summarize the ecocultural framework that informed the design of our study and describe two methods for collecting data (“toy tours” and “mobile phone diaries”) that highlight issues relating to the rules of engagement when conducting research that generates insights into children’s everyday lives at home

Exploring the pedagogic culture of creative play in early childhood education

We present a conceptual analysis, grounded in empirical data, of how young children's creative play is framed by the 'pedagogic culture' within which the child is playing. Drawing on data from a research study with the broad aim of documenting children's creative play in Western play-based early childhood education, we gathered exploratory qualitative observations, self-initiated iPad video diaries and researcher-led activities to describe children's creative play. We adapted the Analysing Children's Creative Thinking Framework as a starting point for coding and the analyses focused on three contextual cues within the pedagogic culture – space, interpersonal collaborations and materials. We ground our discussion in a contextualist theoretical frame to demonstrate that in isolation, each contextual cue presents a degree of framing to children's creative play. When analysed as a synergy of contextual cues, however, we begin to see that the dynamic make-up of each of the contexts, and the interplay among them, create a 'pedagogic culture' that transforms children's creative play. We present 'stories' of each pedagogic culture that we observed, to describe how children's creative play manifested within each culture

“Bibliostory—Educational Comic Stories.” A Social Constructivist Approach to Media and Information Literacy Education for Children and Adolescents

Our paper presents a theoretical background for a Polish comic book “Bibliostory—educational comic stories” (Pl. Bibliostory—edukacyjne historie komiksowe). The comic targets children between 9 and 12 years of age and youths from 13 to 16 years of age. Each story illustrates one issue, such as information searching, organization of information, plagiarism, and information problem solving strategy. Bibliostory is based on two constructivist pedagogical concepts: the zone of proximal development (ZPD) and case-based learning/teaching. These concepts, on application level, are first of all associated with designing educational situations and relationships between teachers and students (educators and learners). The aim of our paper is to present the possibilities of application of these concepts in the educational comic books. We describe the general assumptions of two concepts, then we focus on elements applied in Bibliostory project. We also provide a review of literature on the educational potential of comic books.Zuza Wiorogórska’s work was carried out during her stay as the visiting scholar at the University of California, Berkeley, thanks to a scholarship from the Kosciuszko Foundation. Ewa Rozkosz’s work was carried out thanks to the grant awarded by the Faculty of Education of the University of Lower Silesia for the project “Społeczno-kulturowe podejście w projektowaniu materiałów edukacyjnych na potrzeby edukacji medialnej I inforamacyjnej dzieci i młodzieży na przykładzie »Bibliostory«” (nr 05/ WGW/dok/2016)