Long-term land subsidence and strata compression in Changzhou, China

Changzhou City, underlain by a multi-layered aquifer system in Quaternary sediments in the Great Yangtze River Delta region, experienced a maximum land subsidence rate of 147 mm/year in the early 1980s due to excessive groundwater extraction. A large-scale monitoring station of 11 borehole extensometers was established in the city in 1983 to investigate land subsidence. Nine strata were predetermined in the Quaternary depth interval and monitored by borehole extensometers. Presented in this paper are the long-term observations of land subsidence, strata compression and groundwater level in four aquifers from 1984 to 2002, and discussion on strata compression based on the measured data with reference to the stratigraphy, soil properties, groundwater withdrawn and literature of similar situations. The compression of strata varies significantly and is strongly influenced by groundwater drawdown in the second confined aquifer, or CA2. The groundwater level in CA2 declined from - 55 m in 1981 to - 76 m in 1994 and the land subsidence rate remained high. After the city government enforced restrictions on groundwater extraction in 1995, the extraction rate sharply reduced, the groundwater level in CA2 steadily recovered to - 56 m until 2003, and the land subsidence rate declined to 10 mm/year in 2002. From 1984 to 2002, the land subsidence was mainly attributed to the consolidation of the thick aquitard overlying CA2. In the future, to prevent the subsidence rate from rising, it is vital to stop groundwater drawdown in aquifers. © 2008 Elsevier B.V. All rights reserved

Studying self-care with generative AI tools:Lessons for design

The rise of generative AI presents new opportunities for the understanding and practice of self-care through its capability to generate varied content, including self-care suggestions via text and images, and engage in dialogue with users over time. However, there are also concerns about accuracy and trustworthiness of self-care advice provided via AI. This paper reports our findings from workshops, diaries, and interviews with five researchers and 24 participants to explore their experiences and use of generative AI for self-care. We analyze our findings to present a framework for the use of generative AI to support five types of self-care, – advice seeking, mentorship, resource creation, social simulation, and therapeutic self-expression – mapped across two dimensions – expertise and modality. We discuss how these practices shift the role of technologies for self-care from merely offering information to offering personalized advice and supporting creativity for reflection, and we offer suggestions for using the framework to investigate new self-care designs

Long-term land subsidence and strata compression in Changzhou, China

Changzhou City, underlain by a multi-layered aquifer system in Quaternary sediments in the Great Yangtze River Delta region, experienced a maximum land subsidence rate of 147 mm/year in the early 1980s due to excessive groundwater extraction. A large-scale monitoring station of 11 borehole extensometerswas established in the city in 1983 to investigate land subsidence. Nine stratawere predetermined in the Quaternary depth interval andmonitored by borehole extensometers. Presented in this paper are the long-term observations of land subsidence, strata compression and groundwater level in four aquifers from 1984 to 2002, and discussion on strata compression based on the measured data with reference to the stratigraphy, soil properties, groundwater withdrawn and literature of similar situations. The compression of strata varies significantly and is strongly influenced by groundwater drawdown in the second confined aquifer, or CA2. The groundwater level in CA2 declined from −55 m in 1981 to −76 m in 1994 and the land subsidence rate remained high. After the city government enforced restrictions on groundwater extraction in 1995, the extraction rate sharply reduced, the groundwater level in CA2 steadily recovered to −56 m until 2003, and the land subsidence rate declined to 10 mm/year in 2002. From 1984 to 2002, the land subsidence was mainly attributed to the consolidation of the thick aquitard overlying CA2. In the future, to prevent the subsidence rate from rising, it is vital to stop groundwater drawdown in aquifers

Earth fissures in Jiangsu Province, China and geological investigation of Hetang earth fissure

Earth fissures are a geohazard in Jiangsu Province, China. They can be caused by earthquakes and active faults, underground mining, groundwater extraction and landslides. In order to establish a provincial rehabilitation plan in Jiangsu, a range of monitoring programs, surveys, geological investigations and modeling have been implemented or planned. One of the focuses of the project is the land subsidence and earth fissures caused by excessive groundwater withdrawal in Suzhou, Wuxi and Changzhou (Su-Xi-Chang) area, southern Jiangsu Province. Hetang earth fissure within the Su-Xi-Chang area was first reported in 1995 and a series of investigation has been conducted since then. The site investigations and geophysical survey in 1997 have recognized the causative factor as the excessive groundwater drawdown coupled by the underlying bedrock ridge. An open trench excavation in 2007 and a plane strain analysis suggest that Hetang earth fissures may have cracked from the bedrock ridge to ground surface. Geological drilling in 2007 has further confirmed the existence and configuration of the ridge and extracted soil samples for laboratory tests to obtain soil parameters for numerical analyses and modeling of land subsidence and earth fissures in the Su-Xi-Chang area, Jiangsu, China. The laboratory tests are currently in progress and the result of numerical analyses and modeling is expected to be presented in the near future

UNICORN Babies: Understanding Circulating and Cerebral Creatine Levels of the Preterm Infant. An Observational Study Protocol

Creatine is an essential metabolite for brain function, with a fundamental role in cellular (ATP) energy homeostasis. It is hypothesized that preterm infants will become creatine deplete in the early postnatal period, due to premature delivery from a maternal source of creatine and a limited supply of creatine in newborn nutrition. This potential alteration to brain metabolism may contribute to, or compound, poor neurological outcomes in this high-risk population. Understanding Creatine for Neurological Health in Babies (UNICORN) is an observational study of circulating and cerebral creatine levels in preterm infants. We will recruit preterm infants at gestational ages 23+0–26+6, 27+0–29+6, 30+0–32+6, 33+0–36+6, and a term reference group at 39+0–40+6 weeks of gestation, with 20 infants in each gestational age group. At birth, a maternal capillary blood sample, as well as a venous cord blood sample, will be collected. For preterm infants, serial infant plasma (heel prick), urine, and nutrition samples [total parenteral nutrition (TPN), breast milk, or formula] will be collected between birth and term “due date.” Key fetomaternal information, including demographics, smoking status, and maternal diet, will also be collected. At term corrected postnatal age (CPA), each infant will undergo an MRI/1H-MRS scan to evaluate brain structure and measure cerebral creatine content. A general movements assessment (GMA) will also be conducted. At 3 months of CPA, infants will undergo a second GMA as well as further neurodevelopmental evaluation using the Developmental Assessment of Young Children – Second Edition (DAYC-2) assessment tool. The primary outcome measures for this study are cerebral creatine content at CPA and plasma and urine creatine and guanidinoacetate (creatine precursor) concentrations in the early postnatal period. We will also determine associations between (1) creatine levels at term CPA and neurodevelopmental outcomes (MRI, GMA, and DAY-C); (2) dietary creatine intake and circulating and cerebral creatine content; and (3) creatine levels and maternal characteristics. Novel approaches are needed to try and improve preterm-associated brain injury. Inclusion of creatine in preterm nutrition may better support ex utero brain development through improved cerebral cellular energy availability during a period of significant brain growth and development.Ethics Ref: HDEC 18/CEN/7 New Zealand.ACTRN: ACTRN12618000871246

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Masturbation, sexual logic and capitalism

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