CARACTERÍSTICAS DO DESENHO DO AMBIENTE DAS INSTITUIÇÕES DE EDUCAÇÃO

The article focuses on elucidating the distinctive aspects of designing the environment within educational institutions. It identifies the typical characteristics of design found in domestic higher education institutions, encompassing architectural solutions and functional concepts, as well as principles governing the division of educational spaces and zones. The article also examines the influence of classroom design on academic performance effectiveness. Notable illustrations of contemporary design within the educational environment of Ukrainian higher education institutions are presented. Additionally, the article explores design and architectural solutions employed in educational institutions abroad. Furthermore, the article puts forth original approaches toward shaping a modern design framework for educational institutions' environments. This research aims to uncover the specific characteristics associated with the design of educational institution environments. The object of investigation is the educational institution itself, viewed as a subject for design and architectural solutions. Research methods. The research employed various methods including description, analysis and synthesis, comparison, generalization, and modeling. The article delves into the distinct features associated with the design of educational institution environments. It identifies the defining characteristics of design within Ukrainian higher education institutions, explores the rationale behind such design approaches, and examines the evolution of design in the modern era. The study establishes the key aspects related to the design of specific educational spaces such as study rooms, lecture halls, specialized discipline offices, and computer rooms within Ukrainian higher education institutions (hereinafter HEIs). Additionally, recreational areas are characterized as a unique type of educational space, providing students with an opportunity to rest during breaks and prepare for upcoming classes. The study presents an analysis of the merits and drawbacks of the design of educational environments in contemporary domestic higher education institutions. It discerns the distinctive attributes within each category and assesses their influence on students' academic performance. Moreover, the study emphasizes the emerging trends that should be pursued in the development of modern HEIs design. The article uncovers the distinctive characteristics of designing educational institutions both in Ukraine and abroad. It emphasizes the particulars of designing lecture halls, study rooms, specialized rooms, and laboratories. Building upon the obtained results, this research develops approaches and principles for shaping the design of educational institution environments in Ukraine.O artigo se concentra em elucidar os aspectos distintivos de projetar o ambiente dentro das instituições de ensino. Identifica as características típicas de design encontradas nas instituições de ensino superior nacionais, englobando soluções arquitetônicas e conceitos funcionais, bem como princípios que regem a divisão de espaços e zonas educacionais. O artigo também examina a influência do design da sala de aula na eficácia do desempenho acadêmico. Ilustrações notáveis de design contemporâneo dentro do ambiente educacional de instituições de ensino superior ucranianas são apresentadas. Além disso, o artigo explora soluções de design e arquitetura empregadas em instituições de ensino no exterior. Além disso, o artigo apresenta abordagens originais para moldar uma estrutura de design moderno para ambientes de instituições educacionais. Esta pesquisa tem como objetivo descobrir as características específicas associadas ao design de ambientes de instituições de ensino. O objeto de investigação é a própria instituição de ensino, vista como objeto de projeto e soluções arquitetônicas. Métodos de pesquisa. A pesquisa empregou vários métodos, incluindo descrição, análise e síntese, comparação, generalização e modelagem. O artigo investiga as características distintas associadas ao design de ambientes de instituições de ensino. Ele identifica as características definidoras do design nas instituições de ensino superior ucranianas, explora a lógica por trás dessas abordagens de design e examina a evolução do design na era moderna. O estudo estabelece os principais aspectos relacionados ao projeto de espaços educacionais específicos, como salas de estudo, salas de aula, escritórios de disciplinas especializadas e salas de informática dentro de instituições de ensino superior ucranianas (doravante denominadas IES). Além disso, as áreas de lazer se caracterizam como um tipo único de espaço educacional, proporcionando aos alunos a oportunidade de descansar nos intervalos e se preparar para as próximas aulas. O estudo apresenta uma análise dos méritos e desvantagens do design de ambientes educacionais em instituições de ensino superior nacionais contemporâneas. Ele distingue os atributos distintivos dentro de cada categoria e avalia sua influência no desempenho acadêmico dos alunos. Além disso, o estudo enfatiza as tendências emergentes que devem ser perseguidas no desenvolvimento do design de IES modernas. O artigo revela as características distintivas de projetar instituições educacionais na Ucrânia e no exterior. Ele enfatiza as particularidades de projetar salas de aula, salas de estudo, salas especializadas e laboratórios. Com base nos resultados obtidos, esta pesquisa desenvolve abordagens e princípios para moldar o design de ambientes de instituições educacionais na Ucrânia

Забезпечення контролю якості освітньої діяльності вищих навчальних закладів

Дослідження спрямоване на встановлення загальної концепції та етапів моделювання реалізації контролю якості навчального процесу; для визначення оцінки працівників вищого навчального закладу представлено інноваційну модель контролю якості з використанням автоматизованих систем навчання та контролю (АСКУ). Основним методом був експеримент, у дослідженні також використовувалися анкетний та методи спостереження. Дані проаналізовано шляхом змістового та тематичного аналізу. Основна гіпотеза полягає в тому, що моделі впровадження контролю якості освіти мають бути комплексними, відповідати місії та стратегії навчального закладу та потребувати постійного вдосконалення. Результатом є створення основної концептуальної основи для формування інноваційної моделі контролю якості, яка повинна орієнтуватися на якість освіти, використовувати широкий спектр передових технологій, ефективну комунікацію, вдосконалювати стратегії навчання. Подальшою перспективою є дослідження ефективності моделей контролю якості навчального процесу.The study aims to establish a general concept and stages of modeling the implementation of quality control of the educational process; to determine the assessment of employees of the institution of higher education presented an innovative model of quality control using automated learning and control systems (ALCS). The main method was the experiment, the study also used questionnaire and observation methods. The data was analyzed through content and thematic analysis. The main hypothesis is that the implementation models of quality control of education should be comprehensive, meet the mission and strategy of the educational institution and require continuous improvement. The result is the establishment of the main conceptual framework for the formation of an innovative model of quality control, should focus on quality education, use a wide range of advanced technologies, effective communication, improve learning strategies. A further perspective is to investigate the effectiveness of models of quality control of the educational process

Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.

We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). We find that T cell infiltration and interferon-γ (IFN-γ) signaling signatures correspond most highly with clinical response to therapy, with a reciprocal decrease in cell-cycle and WNT signaling pathways in responding biopsies. We model the interaction in 58 human cell lines, where IFN-γ in vitro exposure leads to a conserved transcriptome response unless cells have IFN-γ receptor alterations. This conserved IFN-γ transcriptome response in melanoma cells serves to amplify the antitumor immune response. Therefore, the magnitude of the antitumor T cell response and the corresponding downstream IFN-γ signaling are the main drivers of clinical response or resistance to immune checkpoint blockade therapy

Conserved interferon-g signaling drives clinical response to immune checkpoint blockade therapy in melanoma

We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). We find that T cell infiltration and interferon-γ (IFN-γ) signaling signatures correspond most highly with clinical response to therapy, with a reciprocal decrease in cell-cycle and WNT signaling pathways in responding biopsies. We model the interaction in 58 human cell lines, where IFN-γ in vitro exposure leads to a conserved transcriptome response unless cells have IFN-γ receptor alterations. This conserved IFN-γ transcriptome response in melanoma cells serves to amplify the antitumor immune response. Therefore, the magnitude of the antitumor T cell response and the corresponding downstream IFN-γ signaling are the main drivers of clinical response or resistance to immune checkpoint blockade therapy

Two-particle Bose-Einstein correlations and their Lévy parameters in PbPb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV

Two-particle Bose-Einstein momentum correlation functions are studied for charged-hadron pairs in lead-lead collisions at a center-of-mass energy per nucleon pair of $\sqrt{s_\mathrm{NN}}$ = 5.02 TeV. The data sample, containing 4.27$\times10^{9}$ minimum bias events corresponding to an integrated luminosity of 0.607 nb$^{-1}$, was collected by the CMS experiment in 2018. The experimental results are discussed in terms of a L\'evy-type source distribution. The parameters of this distribution are extracted as functions of particle pair average transverse mass and collision centrality. These parameters include the L\'evy index or shape parameter ($\alpha$), the L\'evy scale parameter ($R$), and the correlation strength parameter ($\lambda$). The source shape, characterized by $\alpha$, is found to be neither Cauchy nor Gaussian, implying the need for a full L\'evy analysis. Similarly to what was previously found for systems characterized by Gaussian source radii, a hydrodynamical scaling is observed for the L\'evy $R$ parameter. The $\lambda$ parameter is studied in terms of the core-halo model.Comment: Submitted to Physical Review C. All figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/HIN-21-011 (CMS Public Pages

Measurement of inclusive and differential cross sections for single top quark production in association with a W boson in proton-proton collisions at s \sqrt{s} = 13 TeV

International audienceMeasurements of the inclusive and normalised differential cross sections are presented for the production of single top quarks in association with a W boson in proton-proton collisions at a centre-of-mass energy of 13 TeV. The data used were recorded with the CMS detector at the LHC during 2016–2018, and correspond to an integrated luminosity of 138 fb$^{−1}$. Events containing one electron and one muon in the final state are analysed. For the inclusive measurement, a multivariate discriminant, exploiting the kinematic properties of the events is used to separate the signal from the dominant $\textrm{t}\overline{\textrm{t}}$ background. A cross section of $79.2\pm 0.9{\left(\textrm{stat}\right)}_{-8.0}^{+7.7}\left(\textrm{syst}\right)\pm 1.2\left(\textrm{lumi}\right)$ pb is obtained, consistent with the predictions of the standard model. For the differential measurements, a fiducial region is defined according to the detector acceptance, and the requirement of exactly one jet coming from the fragmentation of a bottom quark. The resulting distributions are unfolded to particle level and agree with the predictions at next-to-leading order in perturbative quantum chromodynamics.[graphic not available: see fulltext

Search for nonresonant Higgs boson pair production in final state with two bottom quarks and two tau leptons in proton-proton collisions at <math altimg="si1.svg"><msqrt><mrow><mi>s</mi></mrow></msqrt><mo linebreak="goodbreak" linebreakstyle="after">=</mo><mn>13</mn><mtext> TeV</mtext></math>

International audienceA search for the nonresonant production of Higgs boson pairs (HH ) via gluon-gluon and vector boson fusion processes in final states with two bottom quarks and two tau leptons is presented. The search uses data from proton-proton collisions at a center-of-mass energy of s=13TeV recorded with the CMS detector at the LHC, corresponding to an integrated luminosity of 138fb−1. Events in which at least one tau lepton decays hadronically are considered and multiple machine learning techniques are used to identify and extract the signal. The data are found to be consistent, within uncertainties, with the standard model (SM) predictions. Upper limits on the HH production cross section are set to constrain the parameter space for anomalous Higgs boson couplings. The observed (expected) upper limit at 95% confidence level corresponds to 3.3 (5.2) times the SM prediction for the inclusive HH cross section and to 124 (154) times the SM prediction for the vector boson fusion HH cross section. At 95% confidence level, the Higgs field self-coupling is constrained to be within −1.7 and 8.7 times the SM expectation, and the coupling of two Higgs bosons to two vector bosons is constrained to be within −0.4 and 2.6 times the SM expectation

Measurement of the <math altimg="si1.svg"><mi mathvariant="normal">t</mi><mover accent="true"><mrow><mi mathvariant="normal">t</mi></mrow><mrow><mo stretchy="false">¯</mo></mrow></mover></math> charge asymmetry in events with highly Lorentz-boosted top quarks in pp collisions at <math altimg="si2.svg"><msqrt><mrow><mi>s</mi></mrow></msqrt><mo linebreak="goodbreak" linebreakstyle="after">=</mo><mn>13</mn></math> TeV

International audienceThe measurement of the charge asymmetry in top quark pair events with highly Lorentz-boosted top quarks decaying to a single lepton and jets is presented. The analysis is performed using proton-proton collisions at s=13TeV with the CMS detector at the LHC and corresponding to an integrated luminosity of 138 fb−1. The selection is optimized for top quarks produced with large Lorentz boosts, resulting in nonisolated leptons and overlapping jets. The top quark charge asymmetry is measured for events with a tt¯ invariant mass larger than 750 GeV and corrected for detector and acceptance effects using a binned maximum likelihood fit. The measured top quark charge asymmetry of (0.42−0.69+0.64)% is in good agreement with the standard model prediction at next-to-next-to-leading order in quantum chromodynamic perturbation theory with next-to-leading-order electroweak corrections. The result is also presented for two invariant mass ranges, 750–900 and &gt;900GeV